ZA944807B - Novel indoline derivatives processes for their preparation and their use as cns agents - Google Patents

Novel indoline derivatives processes for their preparation and their use as cns agents

Info

Publication number
ZA944807B
ZA944807B ZA944807A ZA944807A ZA944807B ZA 944807 B ZA944807 B ZA 944807B ZA 944807 A ZA944807 A ZA 944807A ZA 944807 A ZA944807 A ZA 944807A ZA 944807 B ZA944807 B ZA 944807B
Authority
ZA
South Africa
Prior art keywords
preparation
indoline derivatives
cns agents
novel indoline
derivatives processes
Prior art date
Application number
ZA944807A
Other languages
English (en)
Inventor
Peter Ham
Graham Elgin Jones
Ian Thomson Forbes
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of ZA944807B publication Critical patent/ZA944807B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Eyeglasses (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ZA944807A 1993-07-06 1994-07-04 Novel indoline derivatives processes for their preparation and their use as cns agents ZA944807B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB939313913A GB9313913D0 (en) 1993-07-06 1993-07-06 Novel compounds

Publications (1)

Publication Number Publication Date
ZA944807B true ZA944807B (en) 1996-01-04

Family

ID=10738344

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA944807A ZA944807B (en) 1993-07-06 1994-07-04 Novel indoline derivatives processes for their preparation and their use as cns agents

Country Status (15)

Country Link
US (1) US5834494A (ja)
EP (1) EP0707581B1 (ja)
JP (1) JPH08512299A (ja)
CN (1) CN1129937A (ja)
AP (1) AP463A (ja)
AT (1) ATE149163T1 (ja)
AU (1) AU7228394A (ja)
CA (1) CA2166624A1 (ja)
DE (1) DE69401823T2 (ja)
GB (1) GB9313913D0 (ja)
IL (1) IL110204A0 (ja)
MA (1) MA23254A1 (ja)
TW (1) TW297023B (ja)
WO (1) WO1995001976A1 (ja)
ZA (1) ZA944807B (ja)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5618824A (en) * 1994-03-09 1997-04-08 Merrell Pharmaceuticals Inc. Treatment of obsessive-compulsive disorders with 5-HT2 antagonists
GB9414139D0 (en) * 1994-07-13 1994-08-31 Smithkline Beecham Plc Novel compounds
GB9420521D0 (en) * 1994-10-12 1994-11-30 Smithkline Beecham Plc Novel compounds
HU223601B1 (hu) * 1995-02-02 2004-10-28 Smithkline Beecham P.L.C. 5-HT receptor antagonista indolszármazékok
US5972937A (en) * 1995-02-02 1999-10-26 Smithkline Beecham P.L.C. Heterocyclic compounds possessing 5HT2C receptor antagonist activity
GB9517559D0 (en) * 1995-08-26 1995-10-25 Smithkline Beecham Plc Novel compounds
AU2759597A (en) * 1996-05-16 1997-12-05 Allelix Biopharmaceuticals Inc. Thiophene- and furan-tryptamine derivatives
GB9612883D0 (en) * 1996-06-20 1996-08-21 Smithkline Beecham Plc Novel compounds
GB9612885D0 (en) * 1996-06-20 1996-08-21 Smithkline Beecham Plc Novel compounds
US6362009B1 (en) 1997-11-21 2002-03-26 Merck & Co., Inc. Solid phase synthesis of heterocycles
FR2778662B1 (fr) * 1998-05-12 2000-06-16 Adir Nouveaux composes cycliques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO2000023437A1 (fr) * 1998-10-16 2000-04-27 Takeda Chemical Industries, Ltd. Composes azotes hererocycliques condenses; procede de fabrication et agents les renfermant
US6453357B1 (en) 1999-01-07 2002-09-17 Cisco Technology, Inc. Method and system for processing fragments and their out-of-order delivery during address translation
CA2374898C (en) * 1999-05-21 2009-12-08 Biovitrum Ab Pyrazinyl-piperazine compounds, their use and preparation
US6465467B1 (en) 1999-05-21 2002-10-15 Biovitrum Ab Certain aryl-aliphatic and heteroaryl-aliphatic piperazinyl pyrazines and their use in the treatment of serotonin-related diseases
UA77650C2 (en) 1999-12-06 2007-01-15 Lundbeck & Co As H Use of serotonin reuptake inhibitor in combination with deramcyclane
FR2810979B1 (fr) * 2000-06-29 2002-08-23 Adir Nouveaux derives de diphenyluree, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
GB0019950D0 (en) * 2000-08-12 2000-09-27 Smithkline Beecham Plc Compounds
SE0004245D0 (sv) 2000-11-20 2000-11-20 Pharmacia Ab Novel compounds and their use
DE60100294T2 (de) * 2001-07-09 2003-12-11 Alcatel Sel Ag Verbinder für optische Fasern
US6861440B2 (en) 2001-10-26 2005-03-01 Hoffmann-La Roche Inc. DPP IV inhibitors
FR2837823B1 (fr) * 2002-03-27 2005-04-08 Servier Lab Nouveaux derives d'indoline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP1513831B1 (en) 2002-06-19 2010-01-06 Biovitrum AB (publ) Novel compounds, their use and preparation
AU2004251830B8 (en) 2003-06-20 2009-11-26 F. Hoffmann-La Roche Ag Pyrido[2, 1-A]-isoquinoline derivatives as DPP-IV inhibitors
ES2327740T3 (es) 2003-06-20 2009-11-03 F. Hoffmann-La Roche Ag Hexahidropiridoisoquinolinas como inhibidoras de la dpp-iv.
JP5261181B2 (ja) * 2005-09-13 2013-08-14 バイエル・クロップサイエンス・アーゲー 殺虫剤フェニルオキシ置換フェニルアミジン誘導体
US8293100B2 (en) 2009-03-13 2012-10-23 Terrasep, Llc Methods and apparatus for centrifugal liquid chromatography
CN106278987A (zh) * 2016-08-16 2017-01-04 都创(上海)医药科技有限公司 吲哚啉类化合物的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4428881A (en) * 1977-12-23 1984-01-31 Gulf Oil Corporation Control of unwanted vegetation with N-carbamylindolines
EP0550507A1 (en) * 1990-09-13 1993-07-14 Beecham Group p.l.c. Indole ureas as 5 ht receptor antagonist
EP0656003A1 (en) * 1992-08-20 1995-06-07 Smithkline Beecham Plc Condensed indole derivatives as 5ht2c and 5ht2b antagonists

Also Published As

Publication number Publication date
DE69401823D1 (de) 1997-04-03
AP463A (en) 1996-02-19
GB9313913D0 (en) 1993-08-18
TW297023B (ja) 1997-02-01
EP0707581A1 (en) 1996-04-24
WO1995001976A1 (en) 1995-01-19
ATE149163T1 (de) 1997-03-15
AU7228394A (en) 1995-02-06
EP0707581B1 (en) 1997-02-26
AP9400653A0 (en) 1994-07-31
DE69401823T2 (de) 1997-08-28
US5834494A (en) 1998-11-10
CN1129937A (zh) 1996-08-28
CA2166624A1 (en) 1995-01-19
JPH08512299A (ja) 1996-12-24
MA23254A1 (fr) 1995-04-01
IL110204A0 (en) 1995-01-24

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