ZA944338B - Neuropeptide Y Antagonists and Agonists - Google Patents
Neuropeptide Y Antagonists and AgonistsInfo
- Publication number
- ZA944338B ZA944338B ZA944338A ZA944338A ZA944338B ZA 944338 B ZA944338 B ZA 944338B ZA 944338 A ZA944338 A ZA 944338A ZA 944338 A ZA944338 A ZA 944338A ZA 944338 B ZA944338 B ZA 944338B
- Authority
- ZA
- South Africa
- Prior art keywords
- neuropeptide
- agonists
- antagonists
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57545—Neuropeptide Y
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Urology & Nephrology (AREA)
- Reproductive Health (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7931993A | 1993-06-18 | 1993-06-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA944338B true ZA944338B (en) | 1995-02-14 |
Family
ID=22149788
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA944338A ZA944338B (en) | 1993-06-18 | 1994-06-17 | Neuropeptide Y Antagonists and Agonists |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0707490A1 (de) |
JP (1) | JPH11501281A (de) |
AU (1) | AU7174494A (de) |
CA (1) | CA2165200A1 (de) |
WO (1) | WO1995000161A1 (de) |
ZA (1) | ZA944338B (de) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5516653A (en) * | 1993-12-28 | 1996-05-14 | Synaptic Pharmaceutical Corporation | DNA encoding a human neuropeptide Y/peptide YY/pancreatic polypeptide receptor (Y4) and uses thereof |
US5545549A (en) * | 1994-02-03 | 1996-08-13 | Synaptic Pharmaceutical Corporation | DNA encoding a human neuropeptide Y/peptide YY (Y2) receptor and uses thereof |
US5602024A (en) | 1994-12-02 | 1997-02-11 | Synaptic Pharmaceutical Corporation | DNA encoding a hypothalamic atypical neuropeptide Y/peptide YY receptor (Y5) and uses thereof |
US5989920A (en) * | 1994-12-02 | 1999-11-23 | Synaptic Pharmaceutical Corporation | Methods of modifying feeding behavior compounds useful in such methods and DNA encoding a hypothalmic atypical neuropeptide Y/peptide YY receptor Y5 |
EP0759441A3 (de) * | 1995-06-30 | 1999-06-30 | Eli Lilly And Company | Verfahren zur Behandlung von mit Neuropeptid Y assozierten Zuständen |
ZA965346B (en) * | 1995-06-30 | 1997-12-24 | Lilly Co Eli | Methods of treating neuropeptide Y-associated conditions. |
US5943242A (en) | 1995-11-17 | 1999-08-24 | Pact Gmbh | Dynamically reconfigurable data processing system |
FR2754709B1 (fr) | 1996-10-23 | 1999-03-05 | Sanofi Sa | Composition cosmetique contenant un antagoniste des recepteurs du neuropeptide gamma et alpha 2 antagonistes susceptibles d'etre incorpores dans une telle composition |
US6180653B1 (en) * | 1996-12-16 | 2001-01-30 | Banyu Pharmaceutical Co., Ltd. | Aminopyrazole derivatives |
US6542998B1 (en) | 1997-02-08 | 2003-04-01 | Pact Gmbh | Method of self-synchronization of configurable elements of a programmable module |
CA2283564C (en) | 1997-04-15 | 2007-07-10 | Csir | Pharmaceutical compositions having appetite suppressant activity |
US6713265B1 (en) | 1997-06-04 | 2004-03-30 | Synaptic Pharmaceutical Corporation | Methods of modifying feeding behavior, compounds useful in such methods, and DNA encoding a hypothalamic atypical neuropeptide Y/peptide YY receptor (Y5) |
GB2355657B (en) | 1999-10-27 | 2004-07-28 | Phytopharm Plc | Inhibitors Of Gastric Acid Secretion |
GB2363985B (en) | 2000-06-30 | 2004-09-29 | Phytopharm Plc | Extracts,compounds & pharmaceutical compositions having anti-diabetic activity and their use |
GB0217015D0 (en) * | 2002-07-23 | 2002-08-28 | Bioacta Ltd | Peptide 4 |
US7371871B2 (en) | 2003-05-05 | 2008-05-13 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
EP1680120A2 (de) | 2003-11-03 | 2006-07-19 | Probiodrug AG | Zusammenstellungen zur behandlung von neuronalen erkrankungen |
JP4996926B2 (ja) | 2004-02-05 | 2012-08-08 | プロビオドルグ エージー | グルタミニルシクラーゼの新規の阻害剤 |
WO2007097742A1 (en) * | 2006-02-21 | 2007-08-30 | University Of Cincinnati | Methods relating to glucocorticoid induced receptors |
JP5379692B2 (ja) | 2006-11-09 | 2013-12-25 | プロビオドルグ エージー | 潰瘍、癌及び他の疾患の治療のためのグルタミニルシクラーゼの阻害薬としての3−ヒドロキシ−1,5−ジヒドロ−ピロール−2−オン誘導体 |
JP5523107B2 (ja) | 2006-11-30 | 2014-06-18 | プロビオドルグ エージー | グルタミニルシクラーゼの新規阻害剤 |
ZA200905537B (en) | 2007-03-01 | 2010-10-27 | Probiodrug Ag | New use of glutaminyl cyclase inhibitors |
ES2533484T3 (es) | 2007-04-18 | 2015-04-10 | Probiodrug Ag | Derivados de tiourea como inhibidores de la glutaminil ciclasa |
JP5584236B2 (ja) * | 2009-02-20 | 2014-09-03 | イプセン ファルマ ソシエテ パール アクシオン サンプリフィエ | 神経ペプチドy受容体結合化合物を有する細胞毒性コンジュゲート |
CN102325540B (zh) | 2009-02-20 | 2015-09-23 | 益普生制药股份有限公司 | 具有至少一个合成的氨基酸替换的神经肽y的类似物 |
MX2011008775A (es) * | 2009-02-20 | 2011-10-24 | Ipsen Pharma Sas | Analogos de neuropeptidos y con substitucion de prolina en la posicion 34. |
EA022007B1 (ru) | 2009-09-11 | 2015-10-30 | Пробиодруг Аг | Гетероциклические производные в качестве ингибиторов глутаминилциклазы |
JP6026284B2 (ja) | 2010-03-03 | 2016-11-16 | プロビオドルグ エージー | グルタミニルシクラーゼの阻害剤 |
KR101790806B1 (ko) | 2010-03-10 | 2017-11-20 | 프로비오드룩 아게 | 글루타미닐 사이클라제(qc, ec 2.3.2.5)의 헤테로사이클릭 억제제 |
EP2560953B1 (de) | 2010-04-21 | 2016-01-06 | Probiodrug AG | Hemmer der glutaminylzyklase |
WO2012123563A1 (en) | 2011-03-16 | 2012-09-20 | Probiodrug Ag | Benz imidazole derivatives as inhibitors of glutaminyl cyclase |
WO2017034990A1 (en) | 2015-08-21 | 2017-03-02 | Portola Pharmaceuticals, Inc. | Composition and methods of use of tetrahydroisoquinoline small molecules to bind and modulate pcsk9 protein activity |
WO2017034997A1 (en) | 2015-08-21 | 2017-03-02 | Portola Pharmaceuticals, Inc. | Phenylpiperazine proprotein convertase subtilisin/kexin type 9 (pcsk9) modulators and their use |
EP3337497B1 (de) | 2015-08-21 | 2023-07-12 | SRX Cardio, LLC | Zusammensetzung und verfahren zur verwendung von neuartigen kleinen organischen phenylalaninverbindungen zur direkten modulation der pcsk9-proteinaktivität |
US20190119236A1 (en) | 2016-02-23 | 2019-04-25 | Portola Pharmaceuticals, Inc. | Compounds for binding proprotein convertase subtilisin/kexin type 9 (pcsk9) |
PL3461819T3 (pl) | 2017-09-29 | 2020-11-30 | Probiodrug Ag | Inhibitory cyklazy glutaminylowej |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4839343A (en) * | 1987-03-13 | 1989-06-13 | Debiopharm, S.A. | Preparation containing hexatriacontapeptides and methods of use |
US5026685A (en) * | 1988-07-15 | 1991-06-25 | The Salk Institute For Biological Studies | NPY peptide analogs |
ZA896376B (en) * | 1988-08-26 | 1990-05-30 | Merrell Dow Pharma | Neuropeptide y agonists |
-
1994
- 1994-06-16 EP EP94920757A patent/EP0707490A1/de not_active Withdrawn
- 1994-06-16 CA CA002165200A patent/CA2165200A1/en not_active Abandoned
- 1994-06-16 JP JP7502963A patent/JPH11501281A/ja active Pending
- 1994-06-16 WO PCT/US1994/006837 patent/WO1995000161A1/en not_active Application Discontinuation
- 1994-06-16 AU AU71744/94A patent/AU7174494A/en not_active Abandoned
- 1994-06-17 ZA ZA944338A patent/ZA944338B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
CA2165200A1 (en) | 1995-01-05 |
WO1995000161A1 (en) | 1995-01-05 |
AU7174494A (en) | 1995-01-17 |
EP0707490A1 (de) | 1996-04-24 |
JPH11501281A (ja) | 1999-02-02 |
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