ZA944196B - Isolated peptides which form complexes with MHC molecule HLA-C-clone 10 and uses thereof - Google Patents

Isolated peptides which form complexes with MHC molecule HLA-C-clone 10 and uses thereof

Info

Publication number
ZA944196B
ZA944196B ZA944196A ZA944196A ZA944196B ZA 944196 B ZA944196 B ZA 944196B ZA 944196 A ZA944196 A ZA 944196A ZA 944196 A ZA944196 A ZA 944196A ZA 944196 B ZA944196 B ZA 944196B
Authority
ZA
South Africa
Prior art keywords
clone
mhc molecule
form complexes
isolated peptides
tumor rejection
Prior art date
Application number
ZA944196A
Other languages
English (en)
Inventor
Pierre Van Der Bruggen
Thierry Boon-Falleur
Pierre Coulie
Jean-Christophe Renauld
Original Assignee
Ludwig Inst Cancer Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ludwig Inst Cancer Res filed Critical Ludwig Inst Cancer Res
Publication of ZA944196B publication Critical patent/ZA944196B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
ZA944196A 1993-06-17 1994-06-14 Isolated peptides which form complexes with MHC molecule HLA-C-clone 10 and uses thereof ZA944196B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/079,110 US5571711A (en) 1993-06-17 1993-06-17 Isolated nucleic acid molecules coding for BAGE tumor rejection antigen precursors

Publications (1)

Publication Number Publication Date
ZA944196B true ZA944196B (en) 1995-05-11

Family

ID=22148499

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA944196A ZA944196B (en) 1993-06-17 1994-06-14 Isolated peptides which form complexes with MHC molecule HLA-C-clone 10 and uses thereof

Country Status (13)

Country Link
US (7) US5571711A (fr)
EP (1) EP0711173B1 (fr)
JP (1) JP3477523B2 (fr)
KR (1) KR100306464B1 (fr)
CN (1) CN1230535C (fr)
AT (1) ATE267254T1 (fr)
AU (1) AU677680B2 (fr)
DE (1) DE69433790T2 (fr)
FI (1) FI956019A (fr)
NO (1) NO955063L (fr)
NZ (1) NZ268490A (fr)
WO (1) WO1995000159A1 (fr)
ZA (1) ZA944196B (fr)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6328971B1 (en) * 1993-01-22 2001-12-11 Ludwig Institute For Cancer Research MAGE-1 derived nona peptides, and compositions thereof
US5571711A (en) * 1993-06-17 1996-11-05 Ludwig Institute For Cancer Research Isolated nucleic acid molecules coding for BAGE tumor rejection antigen precursors
US5877017A (en) * 1993-06-17 1999-03-02 Ludwig Institute For Cancer Research Isolated nucleic acid molecule encoding peptides which form complexes with MHC molecule HLA-Cw*1601 and uses thereof
US5830753A (en) * 1994-09-30 1998-11-03 Ludwig Institute For Cancer Research Isolated nucleic acid molecules coding for tumor rejection antigen precursor dage and uses thereof.
DE19543649C2 (de) * 1995-11-23 1998-01-29 Boehringer Ingelheim Int Tumorvakzine und Verfahren zu ihrer Herstellung
US5837476A (en) * 1995-03-03 1998-11-17 Ludwig Institute Methods for determining disorders by assaying for a non-tyrosinase, tumor rejection antigen precursor
CO4600681A1 (es) 1996-02-24 1998-05-08 Boehringer Ingelheim Pharma Composicion farmaceutica para la modulacion inmunitaria
CA2258564A1 (fr) * 1996-06-25 1997-12-31 Ludwig Institute For Cancer Research Antigene anticancereux sous forme de phosphorylase agissant sur le glycogene cerebral
US6265215B1 (en) * 1996-09-13 2001-07-24 Ludwig Institute For Cancer Research Isolated peptides which complex with HLA-Cw16 and uses thereof
WO1998032855A1 (fr) 1997-01-27 1998-07-30 Ludwig Institute For Cancer Research Acides nucleiques lage-1 associes aux tumeurs
US5879892A (en) * 1997-04-25 1999-03-09 Ludwig Institute For Cancer Research Leukemia associated genes
US6680191B1 (en) 1997-04-25 2004-01-20 Ludwig Institute For Cancer Isolated nucleic acid molecules coding for tumor rejection antigen precursors of members of the MAGE-C and MAGE-B FAMILIES and uses thereof
US5905145A (en) * 1998-03-06 1999-05-18 Ludwig Institute For Cancer Research Isolated nucleic acid molecules which encode TAGE molecules, and uses thereof
US7001999B1 (en) 1998-04-15 2006-02-21 Ludwig Institute For Cancer Research Tumor associated nucleic acids and uses therefor
US6245525B1 (en) 1998-07-27 2001-06-12 Ludwig Institute For Cancer Research Tumor associated nucleic acids and uses therefor
US6140050A (en) * 1998-06-26 2000-10-31 Ludwig Institute For Cancer Research Methods for determining breast cancer and melanoma by assaying for a plurality of antigens associated therewith
US6734172B2 (en) 1998-11-18 2004-05-11 Pacific Northwest Research Institute Surface receptor antigen vaccines
CN1402782A (zh) 1999-10-19 2003-03-12 路德维哥癌症研究院 Mage－a12抗原肽及其应用
SE0000410D0 (sv) * 2000-02-06 2000-02-06 Lennart Hoeglund Trefas transformatorkärna
US7829084B2 (en) 2001-01-17 2010-11-09 Trubion Pharmaceuticals, Inc. Binding constructs and methods for use thereof
KR100927261B1 (ko) 2001-01-17 2009-11-18 트루비온 파마슈티칼스, 인코포레이티드 결합 도메인-면역글로불린 융합 단백질
CA2474497C (fr) 2002-01-30 2013-12-03 The Brigham And Women's Hospital, Inc. Compositions et methodes associees a tim-3, molecule de surface cellulaire specifique a th1
US7311914B2 (en) * 2002-08-13 2007-12-25 Ludwig Institute For Cancer Research MAGE-A4 antigenic peptides and uses thereof
JP2005537800A (ja) * 2002-09-06 2005-12-15 マンカインド コーポレイション エピトープ配列
WO2004029071A2 (fr) 2002-09-27 2004-04-08 Ludwig Institute For Cancer Research Peptides antigeniques mage-c2 et utilisations correspondantes
US7178491B2 (en) * 2003-06-05 2007-02-20 Caterpillar Inc Control system and method for engine valve actuator
EP2338506A3 (fr) * 2003-06-17 2011-10-12 Mannkind Corporation Combinaisons d'antigènes associés aux tumeurs pour le traitement thérapeutique de différents types de cancer
US20060008468A1 (en) * 2004-06-17 2006-01-12 Chih-Sheng Chiang Combinations of tumor-associated antigens in diagnostics for various types of cancers
US20060159689A1 (en) * 2004-06-17 2006-07-20 Chih-Sheng Chiang Combinations of tumor-associated antigens in diagnostics for various types of cancers
EP1787124A2 (fr) 2004-06-23 2007-05-23 The University Of Texas System Procedes et compositions pour la detection de molecules biologiques faisant appel a un complexe de deux particules
US7309589B2 (en) * 2004-08-20 2007-12-18 Vironix Llc Sensitive detection of bacteria by improved nested polymerase chain reaction targeting the 16S ribosomal RNA gene and identification of bacterial species by amplicon sequencing
US20060159694A1 (en) * 2004-12-29 2006-07-20 Chih-Sheng Chiang Combinations of tumor-associated antigens in compositions for various types of cancers
CA2594224A1 (fr) * 2004-12-29 2006-07-06 Mannkind Corporation Methodes de declenchement, d'accentuation et de maintien de reponses immunitaires contre des epitopes restreints du cmh de classe i a des fins prophylactiques ou therapeutiques
KR20080026181A (ko) 2005-06-17 2008-03-24 맨카인드 코포레이션 암세포 및 종양 기질에 발현된 우성 및 준우성 에피토프에대한 다가 면역반응을 유발하기 위한 방법 및 조성물
US8084592B2 (en) * 2005-06-17 2011-12-27 Mannkind Corporation Multivalent entrain-and-amplify immunotherapeutics for carcinoma
WO2008035350A1 (fr) 2006-09-21 2008-03-27 Vaxil Biotherapeutics Ltd. Vaccins à multiples épitopes spécifiques à un antigène
WO2010080909A1 (fr) 2009-01-08 2010-07-15 Yale University Compositions et procédés d'utilisation de virus de la stomatite vésiculaire à action oncolytique
US20120171246A1 (en) 2009-09-10 2012-07-05 Yale University Immunization to reduce neurotoxicity during treatment with cytolytic viruses
WO2011056993A1 (fr) 2009-11-04 2011-05-12 Yale University Compositions et procédés destinés à traiter le cancer par des virus oncolytiques atténués
AU2013273987B2 (en) 2012-06-15 2018-08-09 Adaptive Biotechnologies Corporation Uniquely tagged rearranged adaptive immune receptor genes in a complex gene set
CN105452483B (zh) 2013-03-15 2019-01-11 适应生物技术公司 复杂基因集合中的独特标记的重排适应性免疫受体基因
US10874621B2 (en) 2013-10-17 2020-12-29 The Brigham And Women's Hospital, Inc. Cationic nanoparticles for co-delivery of nucleic acids and therapeutic agents
US9172477B2 (en) 2013-10-30 2015-10-27 Inthinc Technology Solutions, Inc. Wireless device detection using multiple antennas separated by an RF shield
EP3139909A4 (fr) 2014-05-09 2018-01-03 Yale University Formulation topique de particules enrobées de polyglycérol hyperramifié
WO2016168197A1 (fr) 2015-04-15 2016-10-20 Yale University Compositions destinées à améliorer l'administration d'agents à travers la barrière hémato-encéphalique et leurs procédés d'utilisation
WO2017095751A1 (fr) 2015-12-02 2017-06-08 Partikula Llc Compositions et procédés de modulation du métabolisme de cellules cancéreuses
WO2017173453A1 (fr) 2016-04-01 2017-10-05 The Brigham And Women's Hospital, Inc. Nanoparticules sensibles aux stimuli pour applications biomédicales
EP3512563A1 (fr) 2016-09-16 2019-07-24 The Johns Hopkins University Nanocages protéiques à pénétration de mucus améliorée pour administration tissulaire et intracellulaire ciblée
WO2018112470A1 (fr) 2016-12-16 2018-06-21 The Brigham And Women's Hospital, Inc. Co-administration d'acides nucléiques pour la suppression et l'expression simultanées de gènes cibles
WO2018196782A1 (fr) 2017-04-27 2018-11-01 The University Of Hong Kong Utilisation d'inhibiteurs de hcn pour le traitement du cancer
WO2018237109A1 (fr) 2017-06-23 2018-12-27 Yale University Nanomatériaux présentant une efficacité améliorée d'administration de médicament
WO2023010060A2 (fr) 2021-07-27 2023-02-02 Novab, Inc. Anticorps anti-vlrb génétiquement modifiés présentant des fonctions effectrices immunitaires
US20230172870A1 (en) 2021-12-08 2023-06-08 Yale University Surface conjugation to poly(amine-co-ester) nanoparticles for targeting to cells and tissues
WO2023147552A1 (fr) 2022-01-28 2023-08-03 University Of Georgia Research Foundation, Inc. Compositions radiosensibilisantes et leurs procédés d'utilisation
WO2024050524A1 (fr) 2022-09-01 2024-03-07 University Of Georgia Research Foundation, Inc. Compositions et procédés de direction de l'apolipoprotéine l1 en vue d'induire la mort de cellules de mammifère

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4879213A (en) * 1986-12-05 1989-11-07 Scripps Clinic And Research Foundation Synthetic polypeptides and antibodies related to Epstein-Barr virus early antigen-diffuse
CA2054709A1 (fr) * 1989-04-26 1990-10-27 Brigitte Bouchard Cellule eucaryotique non melanocytique exprimant de facon constitutive une tyrosinase humaine biologiquement active et son utilisation
WO1992020536A1 (fr) 1991-05-20 1992-11-26 Big Unlimited Methode et appareil pour la creation de vitrages isolants
US5342774A (en) * 1991-05-23 1994-08-30 Ludwig Institute For Cancer Research Nucleotide sequence encoding the tumor rejection antigen precursor, MAGE-1
US5558995A (en) * 1993-01-22 1996-09-24 Ludwig Institute For Cancer Research Peptides which are derived from tumor rejection antigen precursor molecule MAGE-1, which complex to MHC molecule HLA-C clone 10, and uses thereof
US6328971B1 (en) * 1993-01-22 2001-12-11 Ludwig Institute For Cancer Research MAGE-1 derived nona peptides, and compositions thereof
US5571711A (en) * 1993-06-17 1996-11-05 Ludwig Institute For Cancer Research Isolated nucleic acid molecules coding for BAGE tumor rejection antigen precursors

Also Published As

Publication number Publication date
CN1230535C (zh) 2005-12-07
AU7171694A (en) 1995-01-17
EP0711173A1 (fr) 1996-05-15
JP3477523B2 (ja) 2003-12-10
JPH09502863A (ja) 1997-03-25
DE69433790D1 (de) 2004-06-24
FI956019A0 (fi) 1995-12-14
NO955063D0 (no) 1995-12-14
US6110694A (en) 2000-08-29
EP0711173A4 (fr) 1998-04-15
AU677680B2 (en) 1997-05-01
WO1995000159A1 (fr) 1995-01-05
KR100306464B1 (ko) 2001-11-30
US6093540A (en) 2000-07-25
KR960703014A (ko) 1996-06-19
US6638512B1 (en) 2003-10-28
EP0711173B1 (fr) 2004-05-19
NZ268490A (en) 1997-12-19
DE69433790T2 (de) 2004-10-07
CN1102213A (zh) 1995-05-03
US5571711A (en) 1996-11-05
ATE267254T1 (de) 2004-06-15
US6465184B1 (en) 2002-10-15
US20030138854A1 (en) 2003-07-24
NO955063L (no) 1996-01-24
FI956019A (fi) 1996-01-25
US5683886A (en) 1997-11-04

Similar Documents

Publication Publication Date Title
ZA944196B (en) Isolated peptides which form complexes with MHC molecule HLA-C-clone 10 and uses thereof
EP0845032A4 (fr) Molecules d'acide nucleique isolees, peptides formant des complexes avec la molecule du complexe majeur d'histocompatibilite (mhc) hla-a2 et leurs applications
ZA958039B (en) Isolated nucleic acid molecule coding for tumor rejection antigen precursor dage and uses thereof
ZA941644B (en) Isolated nucleic acid molecules coding for tumor rejection antigen precursor MAGE-3 and uses thereof
CA2167692A1 (fr) Methode pour diagnostiquer un trouble en determinant l'expression des precurseurs d'antigenes de rejet tumoral gage
IL101963A0 (en) Isolated and purified dna sequences coding antigen expressed by tumor cells and recognized by cytotoxic t cells,and uses thereof
ZA941812B (en) Isolated nucleic acid sequence coding for a tumor rejection antigen precursor processed to at least one tumor rejection antigen presented by HLA-A2
HK1008228A1 (en) Isolated, truncated nucleic acid molecules which code for gage tumor rejection antigen
NZ332369A (en) Isolated nucleic acid molecules which code for GAGE tumor rejection antigen, the tumor rejection antigen, and uses thereof
CA2165435A1 (fr) Nouveaux precurseurs d'antigenes pour le rejet des tumeurs et molecules d'acides nucleiques codant pour ces precurseurs
CA2213001A1 (fr) Molecule isolee d'acide nucleique codant des peptides formant des complexes avec hla-cw*1601 de la molecule du cmh, et ses utilisations
TW372973B (en) Isolated, truncated nucleic acid molecules which code for gage tumor rejection antigen, the tumor rejection antigen, and uses thereof
UA66753C2 (en) Immunostimulator and method for its production
NZ320837A (en) Peptides derived from tumor rejection antigen precursors and presented by hla-b44 useful in diagnostic and therapeutic methodologies