ZA944106B - N-[[1-[4-(4-fluorophenoxy) butyl]-4-piperidinyl]-n-methyl-amino]-2-benzothiazolols as class III antiarrhythmic agents - Google Patents

N-[[1-[4-(4-fluorophenoxy) butyl]-4-piperidinyl]-n-methyl-amino]-2-benzothiazolols as class III antiarrhythmic agents

Info

Publication number
ZA944106B
ZA944106B ZA944106A ZA944106A ZA944106B ZA 944106 B ZA944106 B ZA 944106B ZA 944106 A ZA944106 A ZA 944106A ZA 944106 A ZA944106 A ZA 944106A ZA 944106 B ZA944106 B ZA 944106B
Authority
ZA
South Africa
Prior art keywords
fluorophenoxy
piperidinyl
butyl
pct
class iii
Prior art date
Application number
ZA944106A
Other languages
English (en)
Inventor
Jozef Jan Pieter Heykants
Doris Wilhelm
Marcel Jan Maria Borgers
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of ZA944106B publication Critical patent/ZA944106B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Silver Salt Photography Or Processing Solution Therefor (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
ZA944106A 1993-06-11 1994-06-10 N-[[1-[4-(4-fluorophenoxy) butyl]-4-piperidinyl]-n-methyl-amino]-2-benzothiazolols as class III antiarrhythmic agents ZA944106B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP93201685 1993-06-11

Publications (1)

Publication Number Publication Date
ZA944106B true ZA944106B (en) 1995-12-11

Family

ID=8213890

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA944106A ZA944106B (en) 1993-06-11 1994-06-10 N-[[1-[4-(4-fluorophenoxy) butyl]-4-piperidinyl]-n-methyl-amino]-2-benzothiazolols as class III antiarrhythmic agents

Country Status (34)

Country Link
US (1) US5691354A (enExample)
EP (1) EP0701556B1 (enExample)
JP (1) JP3498145B2 (enExample)
KR (1) KR100337984B1 (enExample)
CN (1) CN1039120C (enExample)
AT (1) ATE159254T1 (enExample)
AU (1) AU678841B2 (enExample)
BG (1) BG62968B1 (enExample)
BR (1) BR9406765A (enExample)
CA (1) CA2163018A1 (enExample)
CZ (1) CZ285766B6 (enExample)
DE (1) DE69406284T2 (enExample)
DK (1) DK0701556T3 (enExample)
ES (1) ES2108471T3 (enExample)
FI (1) FI955916A7 (enExample)
GR (1) GR3025805T3 (enExample)
HU (1) HU221620B1 (enExample)
IL (1) IL109975A (enExample)
LV (1) LV11544B (enExample)
MY (1) MY111222A (enExample)
NO (1) NO305123B1 (enExample)
NZ (1) NZ268575A (enExample)
OA (1) OA10201A (enExample)
PH (1) PH31126A (enExample)
PL (1) PL176775B1 (enExample)
RO (1) RO115523B1 (enExample)
RU (1) RU2122546C1 (enExample)
SG (1) SG48821A1 (enExample)
SI (1) SI9420036A (enExample)
SK (1) SK281175B6 (enExample)
TW (1) TW282469B (enExample)
UA (1) UA41936C2 (enExample)
WO (1) WO1994029305A1 (enExample)
ZA (1) ZA944106B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3404749B2 (ja) * 1996-06-27 2003-05-12 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Ｎ―［４―（ヘテロアリールメチル）フェニル］―ヘテロアリールアミン
IL150650A0 (en) 2000-01-20 2003-02-12 Eisai Co Ltd Piperidine derivatives and pharmaceutical compositions containing the same
RU2246895C2 (ru) * 2002-11-05 2005-02-27 ГУ Новосибирский научно-исследовательский институт патологии кровообращения им. акад. Е.Н. Мешалкина МЗ РФ Способ прогнозирования желудочковых аритмий у кардиохирургических больных
RU2242254C2 (ru) * 2002-11-05 2004-12-20 ГУ Новосибирский научно-исследовательский институт патологии кровообращения им. акад. Е.Н. Мешалкина Способ диагностики аритмий сердца
RU2261121C2 (ru) * 2003-02-17 2005-09-27 ГУ Новосибирский научно-исследовательский институт патологии кровообращения им. акад. Е.Н. Мешалкина МЗ РФ Способ определения степени зависимости от электрокардиостимулятора
RU2261122C2 (ru) * 2003-02-17 2005-09-27 ГУ Новосибирский научно-исследовательский институт патологии кровообращения им. акад. Е.Н. Мешалкина МЗ РФ Способ определения уровня атриовентрикулярной блокады у больных после хирургической коррекции пороков сердца
RU2261123C2 (ru) * 2003-02-17 2005-09-27 ГУ Новосибирский научно-исследовательский институт патологии кровообращения им. акад. Е.Н. Мешалкина МЗ РФ Способ прогнозирования атриовентрикулярных блокад после радикальной кардиохирургической коррекции пороков сердца у детей раннего возраста
RU2261041C2 (ru) * 2003-04-24 2005-09-27 ГУ Новосибирский научно-исследовательский институт патологии кровообращения им. акад. Е.Н. Мешалкина МЗ РФ Способ прогнозирования пароксизмальной эктопической атриовентрикулярной тахикардии
RU2261124C2 (ru) * 2003-04-24 2005-09-27 ГУ Новосибирский научно-исследовательский институт патологии кровообращения им. акад. Е.Н. Мешалкина МЗ РФ Способ оценки электрических свойств рабочего миокарда

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1396964A3 (ru) * 1984-01-09 1988-05-15 Жансен Фармасетика Н.В. (Фирма) Способ получени 4-(бициклогетероциклилметил)пиперидинов или их фармацевтически приемлемых солей присоединени кислот
US4861785A (en) * 1984-12-03 1989-08-29 Janssen Pharmaceutica N.V. Benzoxazol-and benzothiazolamine derivatives, useful as anti-anoxic agents
CA1260474A (en) * 1984-12-03 1989-09-26 Raymond A. Stokbroekx Benzoxazol- and benzothiazolamine derivatives
US5010198A (en) * 1984-12-03 1991-04-23 Janssen Pharmaceutica N.V. Intermediates for the synthesis of benzoxazol- and benzothiazolamine derivatives, useful as anti-anoxic agents
US4749702A (en) * 1985-04-15 1988-06-07 Janssen Pharmaceutica N. V. Antidepressive substituted N-[(4-piperidinyl)alkyl] bicyclic condensed oxazol- and thiazolamines
KR930005004B1 (ko) * 1985-04-15 1993-06-11 쟈안센 파아마슈우티카 엔. 부이. 치환된 n-[(4-피페리디닐)알킬]이환 축합 옥사졸아민 및 티아졸아민의 제조방법
ZW1992A1 (en) * 1991-02-25 1993-09-22 Janssen Pharmaceutica Nv 4-/(2-benzotiazolyl)methylamino/-b-/(3,4-difluorephenoxy)methyl/-1-piperidine ethanol

Also Published As

Publication number Publication date
JP3498145B2 (ja) 2004-02-16
CN1039120C (zh) 1998-07-15
PL311965A1 (en) 1996-03-18
PH31126A (en) 1998-02-23
MY111222A (en) 1999-09-30
UA41936C2 (uk) 2001-10-15
FI955916A0 (fi) 1995-12-08
HUT73679A (en) 1996-09-30
KR100337984B1 (ko) 2002-10-25
IL109975A0 (en) 1994-10-07
AU7183894A (en) 1995-01-03
EP0701556A1 (en) 1996-03-20
LV11544B (en) 1997-08-20
FI955916L (fi) 1995-12-08
PL176775B1 (pl) 1999-07-30
US5691354A (en) 1997-11-25
DE69406284D1 (de) 1997-11-20
BR9406765A (pt) 1996-02-21
NO954801L (no) 1995-11-27
AU678841B2 (en) 1997-06-12
OA10201A (en) 1996-12-18
EP0701556B1 (en) 1997-10-15
CZ285766B6 (cs) 1999-11-17
CN1125443A (zh) 1996-06-26
HU9501971D0 (en) 1995-09-28
RU2122546C1 (ru) 1998-11-27
FI955916A7 (fi) 1995-12-08
SG48821A1 (en) 1998-05-18
CZ319295A3 (en) 1996-03-13
LV11544A (lv) 1996-10-20
SI9420036A (en) 1996-10-31
DK0701556T3 (da) 1998-01-26
HU221620B1 (hu) 2002-12-28
BG62968B1 (bg) 2000-12-29
ES2108471T3 (es) 1997-12-16
IL109975A (en) 1999-04-11
BG100210A (bg) 1996-07-31
JPH08511014A (ja) 1996-11-19
GR3025805T3 (en) 1998-03-31
SK154495A3 (en) 1996-06-05
ATE159254T1 (de) 1997-11-15
NZ268575A (en) 1996-08-27
WO1994029305A1 (en) 1994-12-22
CA2163018A1 (en) 1994-12-22
RO115523B1 (ro) 2000-03-30
SK281175B6 (sk) 2000-12-11
NO954801D0 (no) 1995-11-27
TW282469B (enExample) 1996-08-01
DE69406284T2 (de) 1998-02-19
NO305123B1 (no) 1999-04-06

Similar Documents

Publication Publication Date Title
AU687911B2 (en) Novel benzoyl guanidines, their production and their use in medicaments
ZW8594A1 (en) Substituted azadioxacycbalkenes
PL320560A1 (en) Pharmaceutic composition
SG48821A1 (en) N-[[1-[4-(4-fluorophenoxy)butyl]-4-piperidinyl]-N- methylamino] 2-benzothiazolols as class III antiarrhythmic agents
AU4623396A (en) 1-aryl-2-acylamino-ethane compounds and their use as neurokinin especially neurokinin 1 antagonists
ZA965749B (en) Use of allylamines.
TR199800958A2 (xx) Herbisidal 3,5-Difloropridinleri.
AU1067295A (en) Substituted aminoalkylaminopyridines
CA2426221A1 (en) New neurokinin antagonists, processes for preparing them and pharmaceutical compositions containing these compounds
AU2002210537A1 (en) (4-acylaminopiperidin-1-yl) acetamides as neurokinin antagonists