ZA943320B - Inhibition of tumor neurosis factor and nitric oxide production by retinoic acid - Google Patents

Inhibition of tumor neurosis factor and nitric oxide production by retinoic acid

Info

Publication number
ZA943320B
ZA943320B ZA943320A ZA943320A ZA943320B ZA 943320 B ZA943320 B ZA 943320B ZA 943320 A ZA943320 A ZA 943320A ZA 943320 A ZA943320 A ZA 943320A ZA 943320 B ZA943320 B ZA 943320B
Authority
ZA
South Africa
Prior art keywords
retinoic acid
nitric oxide
inhibition
oxide production
tumor
Prior art date
Application number
ZA943320A
Other languages
English (en)
Inventor
Bharat B Aggarwal
K Mehta
Original Assignee
Res Dev Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Res Dev Foundation filed Critical Res Dev Foundation
Publication of ZA943320B publication Critical patent/ZA943320B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/203—Retinoic acids ; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/07—Retinol compounds, e.g. vitamin A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Communicable Diseases (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Transplantation (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Nutrition Science (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
ZA943320A 1993-05-17 1994-05-16 Inhibition of tumor neurosis factor and nitric oxide production by retinoic acid ZA943320B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/061,471 US5457129A (en) 1993-05-17 1993-05-17 Inhibition of nitric oxide production by retinoic acid

Publications (1)

Publication Number Publication Date
ZA943320B true ZA943320B (en) 1995-11-16

Family

ID=22036008

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA943320A ZA943320B (en) 1993-05-17 1994-05-16 Inhibition of tumor neurosis factor and nitric oxide production by retinoic acid

Country Status (17)

Country Link
US (2) US5457129A (da)
EP (2) EP1243264A3 (da)
JP (2) JPH08510727A (da)
KR (1) KR100345255B1 (da)
AT (1) ATE228363T1 (da)
AU (1) AU697072B2 (da)
CA (1) CA2162990A1 (da)
DE (1) DE69431801T2 (da)
DK (1) DK0708648T3 (da)
ES (1) ES2187522T3 (da)
IL (1) IL109458A (da)
NZ (1) NZ267220A (da)
PT (1) PT708648E (da)
SA (1) SA94150042B1 (da)
TW (1) TW261529B (da)
WO (1) WO1994026277A1 (da)
ZA (1) ZA943320B (da)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5786332A (en) * 1995-03-06 1998-07-28 Trega Biosciences, Inc. Cytokine restraining agents and methods of use in pathologies and conditions associated with altered cytokine levels
US5741774A (en) * 1993-11-12 1998-04-21 Trega Biosciences, Inc. Use of a cytokine regulatory agent to treat rheumatoid arthritis
FR2735371B1 (fr) * 1995-06-19 1997-07-18 Cird Galderma Procede pour identifier des composes antagonistes des recepteurs rars
FR2767058B1 (fr) * 1997-08-05 2000-05-05 Centre Nat Rech Scient Utilisation d'un compose de type retinoide, notamment l'acide retinoique pour la preparation d' un medicament destine au traitement de l'obesite.
EP0908179A1 (en) 1997-08-23 1999-04-14 Werner Bollag Treatment of cell-mediated immune diseases
US8541469B2 (en) * 1997-08-23 2013-09-24 Glaxo Group Limited Treatment of cell-mediated immune diseases
EP1016719A4 (en) * 1997-09-02 2000-12-13 Sumitomo Pharma DNA PARTICIPATING IN THE REGULATION OF THE EXPRESSION OF THE PEBP2 ALPHA A GENE AND USE OF THIS DNA
US6596500B1 (en) * 1998-12-08 2003-07-22 The General Hospital Corporation Binding of retinoids to M6P/IGF-II receptor
US6242473B1 (en) * 1999-01-08 2001-06-05 Maxim Pharmaceuticals, Inc. Treatment and prevention of reactive oxygen metabolite-mediated cellular damage
US6184246B1 (en) 1999-07-30 2001-02-06 The United States Of America As Represented By The Secretary Of Agriculture Inhibition of cytokine production by polymethoxylated flavones
AU7895000A (en) * 1999-10-19 2001-04-30 Kevin C Kain Products and methods for activating ppargamma-rxr and up-regulating monocyte/macrophage cd36 for the treatment of malaria
US6878747B2 (en) * 2001-01-26 2005-04-12 Steven A. Baranowitz Systemic formulations containing beta-carotene and derivatives thereof
JP2004020220A (ja) * 2002-06-12 2004-01-22 Pioneer Electronic Corp 通信システム及び方法、通信端末装置、通信センタ装置、並びにコンピュータプログラム
US7071228B2 (en) * 2002-10-23 2006-07-04 Parks L Dean Method of treating musculoskeletal and connective tissue inflammations
WO2006088747A2 (en) * 2005-02-14 2006-08-24 Mercer University Serum-free reagents for the isolation, cultivation, and cryopreservation of postnatal pluripotent epiblast-like stem cells
WO2007000939A1 (ja) * 2005-06-28 2007-01-04 St. Marianna University, School Of Medicine 局所炎症治療用薬剤
WO2007104030A1 (en) * 2006-03-08 2007-09-13 Kinemed, Inc. Retinoids and related compounds for the treatment of neuroinflammatory conditions, diseases and disorders
WO2011038537A1 (zh) * 2009-09-29 2011-04-07 上海南方基因科技有限公司 败血症以及败血症休克的预测、预防和治疗方法及试剂盒

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4200647A (en) * 1977-12-21 1980-04-29 Hoffmann-La Roche Inc. Vitamin A compositions to treat rheumatic disease
DE3261761D1 (en) * 1981-07-14 1985-02-14 Efamol Ltd Pharmaceutical and dietary composition when used for enhancement of 1-series pg production
US5264578A (en) * 1987-03-20 1993-11-23 Allergan, Inc. Disubstituted acetylenes bearing heterobicyclic groups and heteroaromatic or phenyl groups having retinoid like activity
EP0397774A1 (en) * 1988-02-04 1990-11-22 Board Of Regents, The University Of Texas System Formulation and use of retinoids in treatment of cancer and other diseases
US5157046A (en) * 1988-11-29 1992-10-20 Janssen Pharmaceutica N.V. Method of treating epithelial disorders
US5190876A (en) * 1988-12-27 1993-03-02 Emory University Method of modifying cellular differentiation and function and compositions therefor
JPH051100A (ja) * 1990-07-11 1993-01-08 Teijin Ltd 腫瘍壊死因子活性抑制物質及びその製造方法
GB9028123D0 (en) * 1990-12-28 1991-02-13 Erba Carlo Spa Monoclonal antibodies against human tumor necrosis factor alpha
EP0567566B2 (en) * 1991-01-18 2007-07-04 Amgen Inc., Methods for treating tumor necrosis factor mediated diseases
DE69232586T2 (de) * 1991-07-05 2002-11-28 Peptech Ltd Giftigkeit von tnf und lps ausschaltende peptide
AU3659293A (en) * 1992-02-11 1993-09-03 Allergan, Inc. Heteroaryl substituted phenylethenyl compounds having retinoid-like biological activity

Also Published As

Publication number Publication date
KR100345255B1 (ko) 2002-11-30
SA94150042B1 (ar) 2006-06-17
KR960702311A (ko) 1996-04-27
EP1243264A3 (en) 2002-11-06
EP0708648A1 (en) 1996-05-01
IL109458A (en) 2001-11-25
US5457129A (en) 1995-10-10
WO1994026277A1 (en) 1994-11-24
CA2162990A1 (en) 1994-11-24
IL109458A0 (en) 1994-07-31
JP2005263808A (ja) 2005-09-29
EP0708648A4 (en) 1998-01-14
AU697072B2 (en) 1998-09-24
PT708648E (pt) 2003-04-30
TW261529B (da) 1995-11-01
ES2187522T3 (es) 2003-06-16
DE69431801D1 (de) 2003-01-09
ATE228363T1 (de) 2002-12-15
DE69431801T2 (de) 2003-09-11
AU6944194A (en) 1994-12-12
US5658949A (en) 1997-08-19
DK0708648T3 (da) 2003-03-03
EP0708648B1 (en) 2002-11-27
NZ267220A (en) 2000-08-25
EP1243264A2 (en) 2002-09-25
JPH08510727A (ja) 1996-11-12

Similar Documents

Publication Publication Date Title
ZA943320B (en) Inhibition of tumor neurosis factor and nitric oxide production by retinoic acid
ZA942600B (en) Stabilized polyvinyl chloride
CA2084775A1 (en) Method of treating human prostatic adenocarcinoma
AU1304195A (en) Ovulation control by regulating nitric oxide levels
AU3136793A (en) Electrophoretic deposition of transition metal dichalcogenides
AU2459488A (en) Improved silica
HK1011946A1 (en) Recording apparatus and method having a temperature overrise protection function
ATE181845T1 (de) Strahlungsundurchlässige nichtknickbare dünnwandige einführvorrichtung
BG102161A (en) Improved method for the preparation of lithium-containing spinel based on lithium and manganese oxide
EP0657176A3 (en) Composition with increased water solubility containing a compound insoluble or slightly soluble in water.
GR3036836T3 (en) Sulfur-containing heterocyclic compounds.
EP0553879A3 (en) Process for producing 4-bromomethylbiphenyl compounds
CA2041831A1 (en) N-glycidyl compound
EP0618580A3 (en) Magnetic tape cassette with reduced electrostatic charge.
GB2288292A (en) Tracking external power supply
TW276983B (da)
BG103319A (en) Method for the preparation of hydroxamic acids
EP0319325A3 (en) Photosensitive material and process for forming pattern using the same
AU3006689A (en) Process for the diacylation of compounds containing two aromatic rings
EP0357910A3 (de) Supraleitendes langgestrecktes Gut aus einem beschichteten gewellten Metallrohr
AU4145993A (en) Energy production from the control of probabilities through quantum level induced interactions
FR2705511B1 (fr) Procédé de commande d'un circuit électronique par un courant de polarisation et circuit électronique mettant en Óoeuvre le procédé.
JPS5384954A (en) Ml-236b carboxylic acid ester and remedies of hyperlipemia containing the same
CA2098804A1 (fr) Procede de preparation d'un compose steroide delta 9(11)
JPS5417949A (en) Stabilized synthetic resin composition