ZA943141B - Process for the preparation of 2-{4-(4-(-4-chloro-1-pyrazolyl)butyl)-1-piperazinyl}pyrimidine(lesopitron) - Google Patents

Process for the preparation of 2-{4-(4-(-4-chloro-1-pyrazolyl)butyl)-1-piperazinyl}pyrimidine(lesopitron)

Info

Publication number
ZA943141B
ZA943141B ZA943141A ZA943141A ZA943141B ZA 943141 B ZA943141 B ZA 943141B ZA 943141 A ZA943141 A ZA 943141A ZA 943141 A ZA943141 A ZA 943141A ZA 943141 B ZA943141 B ZA 943141B
Authority
ZA
South Africa
Prior art keywords
piperazinyl
pyrimidine
lesopitron
pyrazolyl
chloro
Prior art date
Application number
ZA943141A
Other languages
English (en)
Inventor
Ramon Merce-Vidal
Jordi Frigola-Constansa
Original Assignee
Esteve Labor Dr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esteve Labor Dr filed Critical Esteve Labor Dr
Publication of ZA943141B publication Critical patent/ZA943141B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Cosmetics (AREA)
ZA943141A 1993-05-10 1994-05-06 Process for the preparation of 2-{4-(4-(-4-chloro-1-pyrazolyl)butyl)-1-piperazinyl}pyrimidine(lesopitron) ZA943141B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9305586A FR2705098B1 (fr) 1993-05-10 1993-05-10 Procédé de préparation de 2-{4-[4-(chloro-1-pyrazolyl)butyl]1-pipérazinyl}pyrimidine (Lesopitron) .

Publications (1)

Publication Number Publication Date
ZA943141B true ZA943141B (en) 1995-01-09

Family

ID=9446957

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA943141A ZA943141B (en) 1993-05-10 1994-05-06 Process for the preparation of 2-{4-(4-(-4-chloro-1-pyrazolyl)butyl)-1-piperazinyl}pyrimidine(lesopitron)

Country Status (24)

Country Link
US (1) US5536836A (ru)
EP (1) EP0624585B1 (ru)
JP (1) JPH06329670A (ru)
KR (1) KR100302383B1 (ru)
CN (1) CN1053898C (ru)
AT (1) ATE183507T1 (ru)
AU (1) AU675513B2 (ru)
BR (1) BR9401901A (ru)
CA (1) CA2122885A1 (ru)
DE (1) DE69420073T2 (ru)
DK (1) DK0624585T3 (ru)
EG (1) EG20804A (ru)
ES (1) ES2089971B1 (ru)
FI (1) FI942159A (ru)
FR (1) FR2705098B1 (ru)
GR (1) GR3031796T3 (ru)
HU (1) HU217445B (ru)
IS (1) IS1650B (ru)
JO (1) JO1793B1 (ru)
NO (1) NO303873B1 (ru)
NZ (1) NZ260443A (ru)
PH (1) PH30932A (ru)
RU (1) RU2116305C1 (ru)
ZA (1) ZA943141B (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5681956A (en) * 1990-12-28 1997-10-28 Neurogen Corporation 4-aryl substituted piperazinylmethyl phenylimidazole derivatives; a new class of dopamine receptor subtype specific ligands
US5633377A (en) * 1990-12-28 1997-05-27 Neurogen Corporation 4-piperidino- and piperazinomethyl-2-cyclohexyl imidazole derivatives; dopamine receptor subtype specific ligands
FR2701260B1 (fr) * 1993-02-05 1995-05-05 Esteve Labor Dr Dérivés de 2-[4-(4-azolylbutyl)-1-pipérazinyl]-5-hydroxypyrimidine, leur préparation et leur application en tant que médicaments.
ES2099031B1 (es) * 1995-05-31 1997-12-01 Esteve Labor Dr Nuevos polimorfos de diclorhidrato de lesopitron y sus formas hidratadas, procedimientos de preparacion y composiciones que los contienen.
US6166205A (en) * 1998-09-02 2000-12-26 Neurogen Corporation 2-Aryl-4-(1-[4-heteroaryl]piperazin-1-yl)methylimidazoles: dopamine . D.sub4 receptor subtype ligands

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4351939A (en) * 1980-10-16 1982-09-28 Mead Johnson & Company Spiro-quaternary ammonium halides and N-(2-pyrimidinyl)piperazinylalkylazaspiroalkanedione process
US4423049A (en) * 1981-12-28 1983-12-27 Mead Johnson & Company 2-[4-[(4,4-Dialkyl-2,6-piperidinedion-1-yl)butyl]-1-piperazinyl]pyrimidines
US4524206A (en) * 1983-09-12 1985-06-18 Mead Johnson & Company 1-Heteroaryl-4-(2,5-pyrrolidinedion-1-yl)alkyl)piperazine derivatives
US4892943A (en) * 1985-10-16 1990-01-09 American Home Products Corporation Fused bicyclic imides with psychotropic activity
FR2642759B1 (fr) * 1989-02-09 1991-05-17 Laboratorios Esteve Sa Derives de pyrimidyl-piperazinyl-alkyl azoles avec activite anxiolytique et/ou tranquillisante
FR2654621B1 (fr) * 1989-11-22 1994-09-23 Esteve Labor Dr Inhibition du syndrome d'abstinence.
FR2672052B1 (fr) * 1991-01-28 1995-05-24 Esteve Labor Dr Derives d'aryl (ou heteroaryl)-piperazinyl-alkyl-azoles, leur preparation et leur application en tant que medicaments.
FR2671972B1 (fr) * 1991-01-25 1995-03-03 Esteve Labor Dr Utilisation de derives 1-h-azole-(omega-(4-(2-pyrimidinyl)-1-piperazinyl)-alkyl) pour la preparation de medicaments destines au traitement des troubles des fonctions cognitives.
FR2673628B1 (fr) * 1991-03-07 1993-07-09 Esteve Labor Dr Procede de preparation de derives d'aryl (ou heteroaryl)-piperazinyl-butyl-azoles.

Also Published As

Publication number Publication date
ATE183507T1 (de) 1999-09-15
EP0624585A1 (fr) 1994-11-17
FI942159A0 (fi) 1994-05-10
NO941758D0 (no) 1994-05-10
IS4163A (is) 1994-11-11
IS1650B (is) 1997-03-25
ES2089971B1 (es) 1998-02-16
CN1053898C (zh) 2000-06-28
DE69420073T2 (de) 2000-01-05
GR3031796T3 (en) 2000-02-29
AU675513B2 (en) 1997-02-06
CA2122885A1 (fr) 1994-11-11
DE69420073D1 (de) 1999-09-23
BR9401901A (pt) 1994-12-13
NZ260443A (en) 1995-04-27
HU217445B (hu) 2000-01-28
ES2089971A1 (es) 1996-10-01
FI942159A (fi) 1994-11-11
HUT69706A (en) 1995-09-28
HU9401501D0 (en) 1994-08-29
PH30932A (en) 1997-12-23
FR2705098B1 (fr) 1995-08-04
KR100302383B1 (ko) 2001-11-22
JO1793B1 (en) 1994-12-25
NO303873B1 (no) 1998-09-14
EG20804A (fr) 2000-03-29
NO941758L (no) 1994-11-11
CN1100096A (zh) 1995-03-15
DK0624585T3 (da) 1999-12-06
FR2705098A1 (fr) 1994-11-18
RU2116305C1 (ru) 1998-07-27
AU6184494A (en) 1994-11-17
EP0624585B1 (fr) 1999-08-18
US5536836A (en) 1996-07-16
JPH06329670A (ja) 1994-11-29

Similar Documents

Publication Publication Date Title
AU2005202135B2 (en) 2-Iminopyrrolidine derivatives
CS309591A3 (en) Unsaturated hydroxyalkyl quinolinic acids and pharmaceuticals based thereon
GR3021938T3 (en) Process for the preparation of pyrrolo[2,3-d]pyrimidines
ZA943141B (en) Process for the preparation of 2-{4-(4-(-4-chloro-1-pyrazolyl)butyl)-1-piperazinyl}pyrimidine(lesopitron)
CA2053709A1 (en) Piperazine derivatives
HU9400321D0 (en) New 2-[4-(4-azolyl-butyl)-1-piperazinyl] derivatives, process for producing them and pharmaceutical compositions containing them
YU26700A (sh) Postupak za cis-1-(2-(4-(6-metoksi-2-fenil-1,2,3,4- tetrahidronaftalen-1-il)fenoksi)etil)pirolidin
RU94015594A (ru) Способ получения 2- {(4-[4-(4-хлоро-1-пиразолил)бутил]1-пиперазинил} -пиримидина (лезопитрон)
MX9701569A (es) Pirimidin(tio)onas substituidas.
AU639612B2 (en) Hydroxyalkylquinoline ether acids as leukotriene antagonists
DE59209762D1 (de) Verfahren zur Herstellung von in 5-Stellung substituierten Cytosinen und anderen 4,5-disubstituierten Pyrimidin-2(1H)-onen, sowie dabei auftretende Zwischenprodukte
PT1252159E (pt) Processo para o fabrico de compostos heterociclicos
ATE122047T1 (de) 4,5,5a,6-tetrahydro-3h-isoxyzolo(5,4,3- k1)acridinderivate, ein verfahren zu ihrer herstellung und ihre verwendung als medikamente.
ES2030634A6 (es) Procedimiento de obtencion del 4-(4-(5-fluoro-2-pirimidinil)-1-piperazinil)-1-(4-fluorofenil)butanol.
TW200510315A (en) Process for the prepatation of 1-(6-methylpyridin-3-yl)-2-[(4-(methylsulphonyl)phenyl]ethanone