ZA942825B - Catalytic antibodies which hydrolyze primary amides - Google Patents

Catalytic antibodies which hydrolyze primary amides

Info

Publication number
ZA942825B
ZA942825B ZA942825A ZA942825A ZA942825B ZA 942825 B ZA942825 B ZA 942825B ZA 942825 A ZA942825 A ZA 942825A ZA 942825 A ZA942825 A ZA 942825A ZA 942825 B ZA942825 B ZA 942825B
Authority
ZA
South Africa
Prior art keywords
catalytic antibodies
primary amides
hydrolyze
hydrolyze primary
amides
Prior art date
Application number
ZA942825A
Other languages
English (en)
Inventor
Andrew Napper
Mark Martin
Richard C Titmas
Wonpyo Hong
Original Assignee
Igen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Igen Inc filed Critical Igen Inc
Publication of ZA942825B publication Critical patent/ZA942825B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0002—Antibodies with enzymatic activity, e.g. abzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/32—Esters thereof
    • C07F9/3205—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/3241—Esters of arylalkanephosphinic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/48—Phosphonous acids [RP(OH)2] including [RHP(=O)(OH)]; Thiophosphonous acids including [RP(SH)2], [RHP(=S)(SH)]; Derivatives thereof
    • C07F9/4808—Phosphonous acids [RP(OH)2] including [RHP(=O)(OH)]; Thiophosphonous acids including [RP(SH)2], [RHP(=S)(SH)]; Derivatives thereof the acid moiety containing a substituent or structure which is considered as characteristic
    • C07F9/4816—Acyclic saturated acids or derivatices which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/5537—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom the heteroring containing the structure -C(=O)-N-C(=O)- (both carbon atoms belong to the heteroring)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/585—Calcitonins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/595—Gastrins; Cholecystokinins [CCK]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C07K7/086—Bombesin; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Wood Science & Technology (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
ZA942825A 1993-04-23 1994-04-22 Catalytic antibodies which hydrolyze primary amides ZA942825B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5249093A 1993-04-23 1993-04-23

Publications (1)

Publication Number Publication Date
ZA942825B true ZA942825B (en) 1996-07-22

Family

ID=21977936

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA942825A ZA942825B (en) 1993-04-23 1994-04-22 Catalytic antibodies which hydrolyze primary amides

Country Status (8)

Country Link
US (1) US6479265B1 (xx)
EP (1) EP0696318A4 (xx)
JP (1) JP3822231B2 (xx)
AU (1) AU6942394A (xx)
CA (1) CA2161114A1 (xx)
IL (2) IL143554A (xx)
WO (1) WO1994025573A1 (xx)
ZA (1) ZA942825B (xx)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1409654E (pt) * 1999-06-16 2008-11-25 Boston Biomedical Res Inst Controlo imunológico dos níveis de beta-amilóide in vivo
US8168592B2 (en) 2005-10-21 2012-05-01 Amgen Inc. CGRP peptide antagonists and conjugates
US8490349B2 (en) * 2011-05-27 2013-07-23 Jeffrey Lutzner In-floor track assembly for sliding panels with built-in drainage system
EP3421488A3 (en) 2012-03-14 2019-04-17 Regeneron Pharmaceuticals, Inc. Multispecific antigen-binding molecules and uses thereof
IL296285A (en) 2015-07-06 2022-11-01 Regeneron Pharma Multispecific antigen binding molecules and their uses
EP3448891A1 (en) 2016-04-28 2019-03-06 Regeneron Pharmaceuticals, Inc. Methods of making multispecific antigen-binding molecules
BR112019025888A2 (pt) 2017-06-07 2020-06-30 Regeneron Pharmaceuticals, Inc. polinucleotídeo que codifica uma proteína terapêutica multidomínio, vetor de terapia gênica, proteína terapêutica multidomínio recombinante, método de expressão, métodos para reduzir o acúmulo de glicogênio em um tecido em um paciente em necessidade, para reduzir o acúmulo de glicogênio em um tecido em um paciente em necessidade epara tratar a deficiência enzimática em um paciente em necessidade e/ou tolerar o paciente à enzima para a qual é deficiente, anticorpo anti-cd63 ou fragmento de ligação a antígeno, e, composição farmacêutica

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5525A (en) * 1978-05-25 1980-01-05 Meiji Seika Kaisha Ltd Preparation of phosphorus-containing amino acid
US5126258A (en) * 1984-09-07 1992-06-30 Scripps Clinic And Research Foundation Molecules with antibody combining sites that exhibit catalytic properties
ATE50999T1 (de) * 1985-06-11 1990-03-15 Ciba Geigy Ag Mikrobizide mittel.
DE3544375A1 (de) * 1985-12-14 1987-06-19 Hoechst Ag Di- und tripeptide mit n-terminalem phosphinothricin, verfahren zu ihrer herstellung und ihre verwendung zur bekaempfung unerwuenschten pflanzenwuchses
ZA893284B (en) * 1988-05-04 1990-03-28 Igen Inc Peptide analogs and their use as haptens to elicit catalytic antibodies
JPH0311088A (ja) * 1989-06-06 1991-01-18 Nissan Chem Ind Ltd ２―アセチルアミノ―４―（ヒドロキシメチルホスフィニル）酪酸の精製方法
FR2650733A1 (fr) * 1989-08-08 1991-02-15 Roussel Uclaf Nouvelles utilisations pesticides du bialaphos

Also Published As

Publication number Publication date
IL143554A (en) 2007-07-04
CA2161114A1 (en) 1994-11-10
IL109408A0 (en) 1994-07-31
IL109408A (en) 2003-12-10
EP0696318A4 (en) 1998-04-15
WO1994025573A1 (en) 1994-11-10
AU6942394A (en) 1994-11-21
JPH09500010A (ja) 1997-01-07
JP3822231B2 (ja) 2006-09-13
US6479265B1 (en) 2002-11-12
EP0696318A1 (en) 1996-02-14

Similar Documents

Publication Publication Date Title
IL104384A0 (en) Detection of catalytic antibodies
GB9412728D0 (en) Toner processes
GB9412757D0 (en) Toner processes
PT837927E (pt) Anticorpos contra cd80
GB9422383D0 (en) Antibodies
HU9500897D0 (en) Amine modified epoxide-resin
GB9312174D0 (en) Gasket
GB9412166D0 (en) Retargetting antibodies
ZA9410284B (en) Anticonvulsant pseudofructopyranose sulfmates
ZA942825B (en) Catalytic antibodies which hydrolyze primary amides
IL143554A0 (en) Catalytic antibodies which hydrolize primary amides
GB9512124D0 (en) Ammoxidation of propane
GB9515850D0 (en) Broad specificity antibodies
AU8421098A (en) Catalytic antibodies which hydrolyze primary amides and methods for eliciting such antibodies
GB2278893B (en) Gasket
GB2277658B (en) Process and arrangement for transmitting information
ZA949286B (en) Catalytic materials
AU124488S (en) Toner bottle
GB9312415D0 (en) Altered antibodies
GB9320508D0 (en) Antibodies
GB9309884D0 (en) Antibodies
ZA96646B (en) Alkoximinoacetic acid amides
GB9401597D0 (en) Altered antibodies
GB9406244D0 (en) Altered antibodies
ZA941123B (en) Catalyst