ZA936507B - Process for the production of protease inhibitors - Google Patents
Process for the production of protease inhibitorsInfo
- Publication number
- ZA936507B ZA936507B ZA936507A ZA936507A ZA936507B ZA 936507 B ZA936507 B ZA 936507B ZA 936507 A ZA936507 A ZA 936507A ZA 936507 A ZA936507 A ZA 936507A ZA 936507 B ZA936507 B ZA 936507B
- Authority
- ZA
- South Africa
- Prior art keywords
- production
- protease inhibitors
- novel
- yeast strains
- transformed yeast
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 title 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 title 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 abstract 3
- 101100327917 Caenorhabditis elegans chup-1 gene Proteins 0.000 abstract 1
- XYWBJDRHGNULKG-OUMQNGNKSA-N desirudin Chemical compound C([C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@H](C(NCC(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N2)=O)CSSC1)C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C)[C@@H](C)O)CSSC1)C(C)C)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 XYWBJDRHGNULKG-OUMQNGNKSA-N 0.000 abstract 1
- 108010073652 desirudin Proteins 0.000 abstract 1
- 239000013604 expression vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Plant Pathology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP92810681 | 1992-09-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA936507B true ZA936507B (en) | 1994-03-23 |
Family
ID=8211979
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA936507A ZA936507B (en) | 1992-09-04 | 1993-09-03 | Process for the production of protease inhibitors |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US5726043A (da) |
| EP (2) | EP1031628A1 (da) |
| JP (2) | JP3949734B2 (da) |
| KR (1) | KR940007180A (da) |
| AT (1) | ATE196927T1 (da) |
| AU (1) | AU675071B2 (da) |
| CA (1) | CA2105425A1 (da) |
| DE (1) | DE69329540T2 (da) |
| DK (1) | DK0592358T3 (da) |
| ES (1) | ES2152943T3 (da) |
| FI (1) | FI933821A (da) |
| GR (1) | GR3035201T3 (da) |
| HU (1) | HU217094B (da) |
| IL (1) | IL106897A0 (da) |
| MX (1) | MX9305375A (da) |
| NO (1) | NO933153L (da) |
| NZ (1) | NZ248558A (da) |
| PT (1) | PT592358E (da) |
| SG (1) | SG49859A1 (da) |
| ZA (1) | ZA936507B (da) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR19990010008A (ko) * | 1997-07-14 | 1999-02-05 | 구광시 | 효모용 프로모터 및 이 프로모터를 포함하는 효모용발현 벡터 |
| US6358705B1 (en) | 1998-07-16 | 2002-03-19 | Novo Nordisk A/S | Method of making proteins in transformed yeast cells |
| US7795205B2 (en) * | 2004-04-12 | 2010-09-14 | Canyon Pharmaceuticals, Inc. | Methods for effecting regression of tumor mass and size in a metastasized pancreatic tumor |
| CN101512001A (zh) | 2006-07-14 | 2009-08-19 | 诺维信股份有限公司 | 提高真菌细胞中基因表达的方法 |
| CN102373216B (zh) * | 2011-10-28 | 2013-06-05 | 元昊 | 一种含有医用水蛭素基因的重组真核汉逊酵母工程菌株的构建及重组水蛭素的生产工艺 |
| EP3428282A1 (en) * | 2017-07-11 | 2019-01-16 | Alderys | Ectoine-producing yeast |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4940661A (en) * | 1984-05-17 | 1990-07-10 | Genentech, Inc. | Metallothionein transcription control sequences and use thereof |
| FR2593518B1 (fr) * | 1985-05-02 | 1989-09-08 | Transgene Sa | Vecteurs d'expression et de secretion de l'hirudine par les levures transformees |
| MY101203A (en) * | 1985-12-12 | 1991-08-17 | Ucp Gen Pharma Ag | Production of thrombin iinhibitors. |
| MC1834A1 (fr) * | 1986-07-10 | 1988-06-03 | Transgene Sa | Bloc fonctionnel d'adn et plasmide codant pour l'hirudine,levure transformee,procede de preparation de l'hirudine,hirudine obtenue et son utilisation |
| AU614959B2 (en) * | 1987-05-07 | 1991-09-19 | Commonwealth Scientific And Industrial Research Organisation | Expression system |
| PT88556B (pt) * | 1987-09-28 | 1992-11-30 | Smithkline Biolog | Processo de integracao genomica estavel e de expressao de uma sequencia de cadificacao estranha, em leveduras |
| GB8809860D0 (en) * | 1988-04-26 | 1988-06-02 | Ciba Geigy Ag | Process for production of polypeptides |
| AU614121B2 (en) * | 1988-05-04 | 1991-08-22 | Novartis Ag | Improvements in the production of polypeptides |
| FR2645175B1 (fr) * | 1989-03-31 | 1994-02-18 | Transgene Sa | Souche de saccharomyces cerevisiaeproductrice d'une proteine heterologue et procede de preparation de ladite proteine heterologue par fermentation de ladite souche |
-
1993
- 1993-08-25 SG SG9607683A patent/SG49859A1/en unknown
- 1993-08-25 DE DE69329540T patent/DE69329540T2/de not_active Expired - Lifetime
- 1993-08-25 EP EP00107334A patent/EP1031628A1/en not_active Withdrawn
- 1993-08-25 EP EP93810608A patent/EP0592358B1/en not_active Expired - Lifetime
- 1993-08-25 PT PT93810608T patent/PT592358E/pt unknown
- 1993-08-25 ES ES93810608T patent/ES2152943T3/es not_active Expired - Lifetime
- 1993-08-25 AT AT93810608T patent/ATE196927T1/de active
- 1993-08-25 DK DK93810608T patent/DK0592358T3/da active
- 1993-08-30 AU AU44994/93A patent/AU675071B2/en not_active Ceased
- 1993-09-01 FI FI933821A patent/FI933821A/fi unknown
- 1993-09-01 NZ NZ248558A patent/NZ248558A/en unknown
- 1993-09-02 MX MX9305375A patent/MX9305375A/es unknown
- 1993-09-02 CA CA002105425A patent/CA2105425A1/en not_active Abandoned
- 1993-09-03 NO NO933153A patent/NO933153L/no not_active Application Discontinuation
- 1993-09-03 JP JP22021593A patent/JP3949734B2/ja not_active Expired - Lifetime
- 1993-09-03 IL IL106897A patent/IL106897A0/xx unknown
- 1993-09-03 KR KR1019930017604A patent/KR940007180A/ko not_active Application Discontinuation
- 1993-09-03 HU HU9302503A patent/HU217094B/hu not_active IP Right Cessation
- 1993-09-03 ZA ZA936507A patent/ZA936507B/xx unknown
-
1996
- 1996-09-16 US US08/715,252 patent/US5726043A/en not_active Expired - Lifetime
-
2001
- 2001-01-10 GR GR20010400019T patent/GR3035201T3/el unknown
-
2003
- 2003-09-18 JP JP2003326835A patent/JP2004000288A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| HU9302503D0 (en) | 1993-11-29 |
| FI933821A (fi) | 1994-03-05 |
| EP1031628A1 (en) | 2000-08-30 |
| CA2105425A1 (en) | 1994-03-05 |
| JP3949734B2 (ja) | 2007-07-25 |
| EP0592358A2 (en) | 1994-04-13 |
| PT592358E (pt) | 2001-03-30 |
| DK0592358T3 (da) | 2001-02-05 |
| NZ248558A (en) | 1995-04-27 |
| DE69329540T2 (de) | 2001-06-07 |
| IL106897A0 (en) | 1993-12-28 |
| FI933821A0 (fi) | 1993-09-01 |
| ES2152943T3 (es) | 2001-02-16 |
| US5726043A (en) | 1998-03-10 |
| SG49859A1 (en) | 2002-03-19 |
| JPH06165691A (ja) | 1994-06-14 |
| KR940007180A (ko) | 1994-04-26 |
| JP2004000288A (ja) | 2004-01-08 |
| NO933153D0 (no) | 1993-09-03 |
| HUT67307A (en) | 1995-03-28 |
| HU217094B (hu) | 1999-11-29 |
| NO933153L (no) | 1994-03-07 |
| ATE196927T1 (de) | 2000-10-15 |
| DE69329540D1 (de) | 2000-11-16 |
| AU675071B2 (en) | 1997-01-23 |
| EP0592358A3 (en) | 1994-09-28 |
| GR3035201T3 (en) | 2001-04-30 |
| MX9305375A (es) | 1994-03-31 |
| AU4499493A (en) | 1994-03-10 |
| EP0592358B1 (en) | 2000-10-11 |
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