ZA932981B - Avermectin difluoro derivatives - Google Patents

Avermectin difluoro derivatives

Info

Publication number
ZA932981B
ZA932981B ZA932981A ZA932981A ZA932981B ZA 932981 B ZA932981 B ZA 932981B ZA 932981 A ZA932981 A ZA 932981A ZA 932981 A ZA932981 A ZA 932981A ZA 932981 B ZA932981 B ZA 932981B
Authority
ZA
South Africa
Prior art keywords
avermectin
disclosed
derivatives
incorporate
compounds
Prior art date
Application number
ZA932981A
Other languages
English (en)
Inventor
Peter T Meinke
Helmut Mrozik
Michael H Fisher
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of ZA932981B publication Critical patent/ZA932981B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ZA932981A 1992-04-29 1993-04-28 Avermectin difluoro derivatives ZA932981B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/875,486 US5229416A (en) 1992-04-29 1992-04-29 Avermectin difluoro derivatives

Publications (1)

Publication Number Publication Date
ZA932981B true ZA932981B (en) 1993-11-10

Family

ID=25365897

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA932981A ZA932981B (en) 1992-04-29 1993-04-28 Avermectin difluoro derivatives

Country Status (10)

Country Link
US (2) US5229416A (fr)
EP (1) EP0638078B1 (fr)
JP (1) JP3170283B2 (fr)
AT (1) ATE207492T1 (fr)
AU (1) AU4109393A (fr)
CA (1) CA2118491C (fr)
DE (1) DE69331007T2 (fr)
ES (1) ES2164660T3 (fr)
WO (1) WO1993022307A1 (fr)
ZA (1) ZA932981B (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5229416A (en) * 1992-04-29 1993-07-20 Merck & Co., Inc. Avermectin difluoro derivatives
CN1040113C (zh) * 1993-10-05 1998-10-07 美国辉瑞有限公司 抗寄生虫药物多哇麦汀(doramectin)的中间体及其制备方法
DE102007007750A1 (de) * 2006-08-17 2008-02-21 Bayer Cropscience Ag Avermectinderivate
US8901163B2 (en) 2007-01-03 2014-12-02 Galderma S.A. Method of treating hyperesthesia, paresthesia, dolor, and pruritus caused by insect stings or noxious weeds or plants using avermectin compound
DE102010064245A1 (de) 2010-12-28 2012-06-28 Bayer Animal Health Gmbh Makrocylischen Lactone und deren Verwendung und deren Kombinationen mit anderen Wirkstoffen
WO2012028556A1 (fr) 2010-08-31 2012-03-08 Bayer Animal Health Gmbh Lactones macrocycliques et leur utilisation et leurs combinaisons avec d'autres substances actives
WO2012054328A1 (fr) 2010-10-20 2012-04-26 Galderma S.A. Méthode de traitement des hémorroïdes à l'aide d'un composé de lactone macrocyclique
US8901090B2 (en) 2010-10-20 2014-12-02 Galderma S.A. Method of treating otitis externa using macrocyclic lactone compound
CN103360444B (zh) * 2012-04-03 2016-05-11 浙江海正药业股份有限公司 抗寄生虫药赛拉菌素的合成新工艺
CN103896961A (zh) * 2014-03-25 2014-07-02 武汉大学 一种米尔贝肟类化合物及其制备方法
CN113563395B (zh) * 2021-08-09 2023-06-02 河北威远生物化工有限公司 一种阿维菌素b2衍生物及其制备方法和应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4171314A (en) * 1977-12-19 1979-10-16 Merck & Co., Inc. 13-Halo and 13-deoxy C-076 compounds
US4173571A (en) * 1977-12-19 1979-11-06 Merck & Co., Inc. 13-Halo and 13-deoxy derivatives of C-076 compounds
EP0180539A1 (fr) * 1984-09-18 1986-05-07 Ciba-Geigy Ag 13-Halo- et 13-hydroxymilbémycine
JPS6289685A (ja) * 1985-05-31 1987-04-24 Sankyo Co Ltd １３−ハロゲンミルベマイシン誘導体
NZ228866A (en) * 1988-05-02 1991-10-25 Merck & Co Inc Fluoro-substituted milbemycins and avermectins for combatting parasites and insects
AU613521B2 (en) * 1988-09-02 1991-08-01 Sankyo Company Limited 13-substituted milbemycin derivatives, their preparation and use
ATE130006T1 (de) * 1989-09-11 1995-11-15 American Cyanamid Co 13-alkyl-23-imino und 13-halo-23-imino-derivate von ll-f28249-verbindungen und ihre verwendung als endo- und ectoparasitizide, insektizide, akarizide und nematozide mittel.
US5229415A (en) * 1992-03-24 1993-07-20 Merck & Co., Inc. Alkylthio alkyl avermectins are active antiparasitic agents
US5229416A (en) * 1992-04-29 1993-07-20 Merck & Co., Inc. Avermectin difluoro derivatives

Also Published As

Publication number Publication date
CA2118491A1 (fr) 1993-11-11
ATE207492T1 (de) 2001-11-15
DE69331007D1 (de) 2001-11-29
EP0638078A1 (fr) 1995-02-15
US5350742A (en) 1994-09-27
EP0638078B1 (fr) 2001-10-24
JP3170283B2 (ja) 2001-05-28
CA2118491C (fr) 1999-09-14
WO1993022307A1 (fr) 1993-11-11
US5229416A (en) 1993-07-20
EP0638078A4 (en) 1995-03-22
AU4109393A (en) 1993-11-29
DE69331007T2 (de) 2002-06-06
ES2164660T3 (es) 2002-03-01
JPH07506361A (ja) 1995-07-13

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