ATE207492T1 - Difluoroavermectin-derivate - Google Patents

Difluoroavermectin-derivate

Info

Publication number
ATE207492T1
ATE207492T1 AT93910687T AT93910687T ATE207492T1 AT E207492 T1 ATE207492 T1 AT E207492T1 AT 93910687 T AT93910687 T AT 93910687T AT 93910687 T AT93910687 T AT 93910687T AT E207492 T1 ATE207492 T1 AT E207492T1
Authority
AT
Austria
Prior art keywords
derivatives
disclosed
avermectin
incorporate
compounds
Prior art date
Application number
AT93910687T
Other languages
English (en)
Inventor
Peter T Meinke
Helmut Mrozik
Michael H Fisher
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of ATE207492T1 publication Critical patent/ATE207492T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Agronomy & Crop Science (AREA)
  • Dentistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT93910687T 1992-04-29 1993-04-20 Difluoroavermectin-derivate ATE207492T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/875,486 US5229416A (en) 1992-04-29 1992-04-29 Avermectin difluoro derivatives
PCT/US1993/003737 WO1993022307A1 (en) 1992-04-29 1993-04-20 Avermectin difluoro derivatives

Publications (1)

Publication Number Publication Date
ATE207492T1 true ATE207492T1 (de) 2001-11-15

Family

ID=25365897

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93910687T ATE207492T1 (de) 1992-04-29 1993-04-20 Difluoroavermectin-derivate

Country Status (10)

Country Link
US (2) US5229416A (de)
EP (1) EP0638078B1 (de)
JP (1) JP3170283B2 (de)
AT (1) ATE207492T1 (de)
AU (1) AU4109393A (de)
CA (1) CA2118491C (de)
DE (1) DE69331007T2 (de)
ES (1) ES2164660T3 (de)
WO (1) WO1993022307A1 (de)
ZA (1) ZA932981B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5229416A (en) * 1992-04-29 1993-07-20 Merck & Co., Inc. Avermectin difluoro derivatives
CN1040113C (zh) * 1993-10-05 1998-10-07 美国辉瑞有限公司 抗寄生虫药物多哇麦汀(doramectin)的中间体及其制备方法
DE102007007750A1 (de) * 2006-08-17 2008-02-21 Bayer Cropscience Ag Avermectinderivate
US8901163B2 (en) 2007-01-03 2014-12-02 Galderma S.A. Method of treating hyperesthesia, paresthesia, dolor, and pruritus caused by insect stings or noxious weeds or plants using avermectin compound
DE102010064245A1 (de) 2010-12-28 2012-06-28 Bayer Animal Health Gmbh Makrocylischen Lactone und deren Verwendung und deren Kombinationen mit anderen Wirkstoffen
WO2012028556A1 (en) 2010-08-31 2012-03-08 Bayer Animal Health Gmbh Macrocyclic lactones and their use and their combinations with other active substances
EP2629770B1 (de) 2010-10-20 2016-05-25 Galderma S.A. Ivermectin zur behandlung von gehörgangsentzündungen
CA2811924C (en) 2010-10-20 2015-06-16 Galderma S.A. Method of treating hemorrhoids using macrocyclic lactone compound
CN103360444B (zh) 2012-04-03 2016-05-11 浙江海正药业股份有限公司 抗寄生虫药赛拉菌素的合成新工艺
CN103896961A (zh) * 2014-03-25 2014-07-02 武汉大学 一种米尔贝肟类化合物及其制备方法
CN113563395B (zh) * 2021-08-09 2023-06-02 河北威远生物化工有限公司 一种阿维菌素b2衍生物及其制备方法和应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4173571A (en) * 1977-12-19 1979-11-06 Merck & Co., Inc. 13-Halo and 13-deoxy derivatives of C-076 compounds
US4171314A (en) * 1977-12-19 1979-10-16 Merck & Co., Inc. 13-Halo and 13-deoxy C-076 compounds
EP0180539A1 (de) * 1984-09-18 1986-05-07 Ciba-Geigy Ag 13-Halo- und 13-Hydroximilbemycine
JPS6289685A (ja) * 1985-05-31 1987-04-24 Sankyo Co Ltd １３−ハロゲンミルベマイシン誘導体
NZ228866A (en) * 1988-05-02 1991-10-25 Merck & Co Inc Fluoro-substituted milbemycins and avermectins for combatting parasites and insects
AU613521B2 (en) * 1988-09-02 1991-08-01 Sankyo Company Limited 13-substituted milbemycin derivatives, their preparation and use
ES2081880T3 (es) * 1989-09-11 1996-03-16 American Cyanamid Co Derivados 13-alquil-23-imino- y 13-halo-23-imino de compuestos ll-f28249 y su uso como agentes endo- y ectoparasiticidas, insecticidas, acaricidas y nematocidas.
US5229415A (en) * 1992-03-24 1993-07-20 Merck & Co., Inc. Alkylthio alkyl avermectins are active antiparasitic agents
US5229416A (en) * 1992-04-29 1993-07-20 Merck & Co., Inc. Avermectin difluoro derivatives

Also Published As

Publication number Publication date
US5229416A (en) 1993-07-20
AU4109393A (en) 1993-11-29
CA2118491A1 (en) 1993-11-11
WO1993022307A1 (en) 1993-11-11
CA2118491C (en) 1999-09-14
US5350742A (en) 1994-09-27
EP0638078A4 (en) 1995-03-22
DE69331007T2 (de) 2002-06-06
JPH07506361A (ja) 1995-07-13
JP3170283B2 (ja) 2001-05-28
ZA932981B (en) 1993-11-10
ES2164660T3 (es) 2002-03-01
EP0638078B1 (de) 2001-10-24
DE69331007D1 (de) 2001-11-29
EP0638078A1 (de) 1995-02-15

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties