ES2164660T3 - Derivados difluoro de avermectina. - Google Patents

Derivados difluoro de avermectina.

Info

Publication number
ES2164660T3
ES2164660T3 ES93910687T ES93910687T ES2164660T3 ES 2164660 T3 ES2164660 T3 ES 2164660T3 ES 93910687 T ES93910687 T ES 93910687T ES 93910687 T ES93910687 T ES 93910687T ES 2164660 T3 ES2164660 T3 ES 2164660T3
Authority
ES
Spain
Prior art keywords
derivatives
disclosed
difluoro
avermectin
incorporate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93910687T
Other languages
English (en)
Inventor
Peter T Meinke
Helmut Mrozik
Michael H Fisher
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of ES2164660T3 publication Critical patent/ES2164660T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Agronomy & Crop Science (AREA)
  • Dentistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE DESCRIBEN DERIVADOS DE AVERMECTINA QUE INCORPORAN DOS ATOMOS DE FLUOR EN LA POSICION 4'' MONOSACARIDA, LA POSICION 4'''' DISACARIDA O LA POSICION 23. TAMBIEN SE DESCRIBEN DERIVADOS DE AVERMECTINA AGLICONA QUE INCORPORAN DOS ATOMOS DE FLUOR EN POSICION 13 O 23. ESTOS ANALOGOS DE DIFLUORO AVERMECTINA SON DERIVADOS DE CORRESPONDIENTES CETONAS Y ENONAS QUE EN DEFINITIVA SON PREPARADAS POR MODIFICACION QUIMICA DE AVERMECTINAS QUE SE PRODUCEN NATURALMENTE. ESTOS COMPUESTOS SE USAN COMO AGENTES ANTIPARASITOS, INSECTICIDAS Y VERMICIDAS EN HUMANOS Y ANIMALES Y TAMBIEN SE DESCRIBEN COMPOSICIONES QUE CONTIENEN TALES COMPUESTOS COMO EL INGREDIENTE ACTIVO DE ELLOS.
ES93910687T 1992-04-29 1993-04-20 Derivados difluoro de avermectina. Expired - Lifetime ES2164660T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/875,486 US5229416A (en) 1992-04-29 1992-04-29 Avermectin difluoro derivatives

Publications (1)

Publication Number Publication Date
ES2164660T3 true ES2164660T3 (es) 2002-03-01

Family

ID=25365897

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93910687T Expired - Lifetime ES2164660T3 (es) 1992-04-29 1993-04-20 Derivados difluoro de avermectina.

Country Status (10)

Country Link
US (2) US5229416A (es)
EP (1) EP0638078B1 (es)
JP (1) JP3170283B2 (es)
AT (1) ATE207492T1 (es)
AU (1) AU4109393A (es)
CA (1) CA2118491C (es)
DE (1) DE69331007T2 (es)
ES (1) ES2164660T3 (es)
WO (1) WO1993022307A1 (es)
ZA (1) ZA932981B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5229416A (en) * 1992-04-29 1993-07-20 Merck & Co., Inc. Avermectin difluoro derivatives
CN1040113C (zh) * 1993-10-05 1998-10-07 美国辉瑞有限公司 抗寄生虫药物多哇麦汀(doramectin)的中间体及其制备方法
DE102007007750A1 (de) * 2006-08-17 2008-02-21 Bayer Cropscience Ag Avermectinderivate
US8901163B2 (en) 2007-01-03 2014-12-02 Galderma S.A. Method of treating hyperesthesia, paresthesia, dolor, and pruritus caused by insect stings or noxious weeds or plants using avermectin compound
DE102010064245A1 (de) 2010-12-28 2012-06-28 Bayer Animal Health Gmbh Makrocylischen Lactone und deren Verwendung und deren Kombinationen mit anderen Wirkstoffen
WO2012028556A1 (en) 2010-08-31 2012-03-08 Bayer Animal Health Gmbh Macrocyclic lactones and their use and their combinations with other active substances
EP2629772B1 (en) 2010-10-20 2016-05-18 Galderma S.A. Ivermectin for use in the treatment of hemorrhoids
US8901090B2 (en) 2010-10-20 2014-12-02 Galderma S.A. Method of treating otitis externa using macrocyclic lactone compound
CN103360444B (zh) * 2012-04-03 2016-05-11 浙江海正药业股份有限公司 抗寄生虫药赛拉菌素的合成新工艺
CN103896961A (zh) * 2014-03-25 2014-07-02 武汉大学 一种米尔贝肟类化合物及其制备方法
CN113563395B (zh) * 2021-08-09 2023-06-02 河北威远生物化工有限公司 一种阿维菌素b2衍生物及其制备方法和应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4173571A (en) * 1977-12-19 1979-11-06 Merck & Co., Inc. 13-Halo and 13-deoxy derivatives of C-076 compounds
US4171314A (en) * 1977-12-19 1979-10-16 Merck & Co., Inc. 13-Halo and 13-deoxy C-076 compounds
EP0180539A1 (de) * 1984-09-18 1986-05-07 Ciba-Geigy Ag 13-Halo- und 13-Hydroximilbemycine
JPS6289685A (ja) * 1985-05-31 1987-04-24 Sankyo Co Ltd １３−ハロゲンミルベマイシン誘導体
NZ228866A (en) * 1988-05-02 1991-10-25 Merck & Co Inc Fluoro-substituted milbemycins and avermectins for combatting parasites and insects
AU613521B2 (en) * 1988-09-02 1991-08-01 Sankyo Company Limited 13-substituted milbemycin derivatives, their preparation and use
ES2081880T3 (es) * 1989-09-11 1996-03-16 American Cyanamid Co Derivados 13-alquil-23-imino- y 13-halo-23-imino de compuestos ll-f28249 y su uso como agentes endo- y ectoparasiticidas, insecticidas, acaricidas y nematocidas.
US5229415A (en) * 1992-03-24 1993-07-20 Merck & Co., Inc. Alkylthio alkyl avermectins are active antiparasitic agents
US5229416A (en) * 1992-04-29 1993-07-20 Merck & Co., Inc. Avermectin difluoro derivatives

Also Published As

Publication number Publication date
ZA932981B (en) 1993-11-10
ATE207492T1 (de) 2001-11-15
CA2118491A1 (en) 1993-11-11
EP0638078B1 (en) 2001-10-24
EP0638078A4 (en) 1995-03-22
JPH07506361A (ja) 1995-07-13
US5229416A (en) 1993-07-20
DE69331007D1 (de) 2001-11-29
AU4109393A (en) 1993-11-29
JP3170283B2 (ja) 2001-05-28
CA2118491C (en) 1999-09-14
EP0638078A1 (en) 1995-02-15
US5350742A (en) 1994-09-27
WO1993022307A1 (en) 1993-11-11
DE69331007T2 (de) 2002-06-06

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