ZA925391B - Trifluoromethylbenzylphosphonates useful in treating osteoporosis - Google Patents
Trifluoromethylbenzylphosphonates useful in treating osteoporosisInfo
- Publication number
- ZA925391B ZA925391B ZA925391A ZA925391A ZA925391B ZA 925391 B ZA925391 B ZA 925391B ZA 925391 A ZA925391 A ZA 925391A ZA 925391 A ZA925391 A ZA 925391A ZA 925391 B ZA925391 B ZA 925391B
- Authority
- ZA
- South Africa
- Prior art keywords
- trifluoromethylbenzylphosphonates
- useful
- treating osteoporosis
- osteoporosis
- treating
- Prior art date
Links
- 208000001132 Osteoporosis Diseases 0.000 title 1
- FNYSFBUQYJDECF-UHFFFAOYSA-N benzyl(trifluoromethoxy)phosphinic acid Chemical class FC(F)(F)OP(O)(=O)CC1=CC=CC=C1 FNYSFBUQYJDECF-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
- C07F9/6533—Six-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3882—Arylalkanephosphonic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4056—Esters of arylalkanephosphonic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Physical Education & Sports Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/732,267 US5300687A (en) | 1991-07-18 | 1991-07-18 | Trifluoromethylbenzylphosphonates useful in treating osteoporosis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA925391B true ZA925391B (en) | 1994-01-17 |
Family
ID=24942866
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA925391A ZA925391B (en) | 1991-07-18 | 1992-07-17 | Trifluoromethylbenzylphosphonates useful in treating osteoporosis |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US5300687A (de) |
| EP (1) | EP0524023A1 (de) |
| JP (1) | JPH05213977A (de) |
| KR (1) | KR930002364A (de) |
| CN (1) | CN1070408A (de) |
| AU (1) | AU657146B2 (de) |
| CA (1) | CA2074020A1 (de) |
| FI (1) | FI923289A (de) |
| HU (1) | HUT62907A (de) |
| IE (1) | IE922341A1 (de) |
| MX (1) | MX9204229A (de) |
| NO (1) | NO922851L (de) |
| TW (1) | TW216796B (de) |
| ZA (1) | ZA925391B (de) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5300687A (en) * | 1991-07-18 | 1994-04-05 | Ortho Pharmaceutical Corporation | Trifluoromethylbenzylphosphonates useful in treating osteoporosis |
| ZA941088B (en) * | 1993-02-19 | 1995-09-27 | Symphar Sa | Substituted ketophosphonates the processes for their preparation and pharmaceutical compositions containing them |
| EP0625522B1 (de) * | 1993-05-18 | 1998-08-19 | Takeda Chemical Industries, Ltd. | Benzopyran-Derivate und ihre Verwendung |
| CN1151744A (zh) * | 1994-07-04 | 1997-06-11 | 武田药品工业株式会社 | 膦酸化合物及其制备和应用 |
| US5691153A (en) * | 1996-09-06 | 1997-11-25 | Creighton University | Genetic markers to detect high bone mass |
| US5922697A (en) * | 1996-10-02 | 1999-07-13 | Warner-Lambert Company | Compounds, compositions and methods for inhibiting the binding of proteins containing an SH2 domain to cognate phosphorylated proteins |
| US6566353B2 (en) * | 1996-12-30 | 2003-05-20 | Bone Care International, Inc. | Method of treating malignancy associated hypercalcemia using active vitamin D analogues |
| US20020128240A1 (en) * | 1996-12-30 | 2002-09-12 | Bone Care International, Inc. | Treatment of hyperproliferative diseases using active vitamin D analogues |
| US6911553B1 (en) | 1997-10-02 | 2005-06-28 | Roche Diagnostics Gmbh | Osteoblast-specific mitogens and drugs containing such compounds |
| EP0906759A1 (de) | 1997-10-02 | 1999-04-07 | Roche Diagnostics GmbH | Neue Osteoblastenspezifische Mitogene: Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
| FR2771102B1 (fr) * | 1997-11-14 | 2000-12-15 | Biocoral Inc | Procede pour induire la differenciation osteoblastique de cellules de tissu adipeux extramedullaire humain |
| US6979728B2 (en) * | 1998-05-04 | 2005-12-27 | Baylor College Of Medicine | Articles of manufacture and methods for array based analysis of biological molecules |
| AU1525700A (en) | 1998-11-19 | 2000-06-05 | Board Of Trustees Of The University Of Arkansas, The | Increasing bone strength with selected bisphosphonates |
| US20020150887A1 (en) * | 2000-11-09 | 2002-10-17 | National Institute Of Advanced Industrial Science And Technology | Methods and nucleic acid probes for molecular genetic analysis of polluted environments and environmental samples |
| US20050032060A1 (en) * | 2001-08-31 | 2005-02-10 | Shishir Shah | Arrays comprising pre-labeled biological molecules and methods for making and using these arrays |
| US7439346B2 (en) * | 2001-10-12 | 2008-10-21 | Perkinelmer Las Inc. | Nucleic acids arrays and methods of use therefor |
| US7335470B2 (en) | 2001-10-12 | 2008-02-26 | Perkinelmer, Las, Inc. | Compilations of nucleic acids and arrays and methods of using them |
| US6916621B2 (en) * | 2002-03-27 | 2005-07-12 | Spectral Genomics, Inc. | Methods for array-based comparitive binding assays |
| DE10259245A1 (de) | 2002-12-17 | 2004-07-01 | Merck Patent Gmbh | Derivate des Asimadolins mit kovalent gebundenen Säuren |
| JP2006522833A (ja) * | 2003-04-11 | 2006-10-05 | バー・ラボラトリーズ，インコーポレイテッド | エストロゲンおよびプロゲスチンの投与法 |
| WO2005090370A1 (en) | 2004-02-05 | 2005-09-29 | The Regents Of The University Of California | Pharmacologically active agents containing esterified phosphonates and methods for use thereof |
| US8821884B2 (en) * | 2004-07-27 | 2014-09-02 | The Regents Of The University Of California | Compositions and methods using MD-2 mutants and chimeric proteins |
| CN1302001C (zh) * | 2005-01-20 | 2007-02-28 | 申厚宝 | 邻氯苄基膦酸二甲酯生产工艺 |
| EP2842559A3 (de) | 2005-04-08 | 2015-03-18 | Chimerix, Inc. | Verbindungen, Zusammensetzungen und Verfahren zur Behandlung viraler Infektionen und anderer Erkrankungen |
| EP1868628B1 (de) | 2005-04-08 | 2014-06-11 | Chimerix, Inc. | Verbindungen, zusammensetzungen und verfahren zur behandlung von pockenvirus-infektionen |
| WO2007083643A1 (ja) | 2006-01-18 | 2007-07-26 | National University Corporation Tokyo Medical And Dental University | 骨形成促進物質とナノゲルを含有する骨形成用生体材料 |
| EP2136801B1 (de) | 2007-03-30 | 2012-08-29 | Tioga Pharmaceuticals, Inc. | Kappa-opiat-agonisten zur behandlung des diarrhö-dominanten und abwechselnden reizdarmsyndroms |
| EP2254582B1 (de) * | 2008-01-25 | 2016-01-20 | Chimerix, Inc. | Verfahren zur behandlung von virusinfektionen |
| EP2304820A1 (de) | 2008-07-18 | 2011-04-06 | Georgia Tech Research Corporation | Stabile elektroden mit modifizierten arbeitsfunktionen und verfahren für organische elektronische bauelemente |
| US8481286B2 (en) | 2008-08-12 | 2013-07-09 | Allylix, Inc. | Method for production of isoprenoid compounds |
| WO2010031074A2 (en) | 2008-09-15 | 2010-03-18 | Genentech, Inc. | Compositions and methods for regulating cell osmolarity |
| JP5350733B2 (ja) * | 2008-09-30 | 2013-11-27 | 株式会社クレハ | ホスホン酸、ホスホン酸銅化合物、樹脂組成物及び積層体 |
| JP5699127B2 (ja) | 2009-04-06 | 2015-04-08 | ジョージア・テック・リサーチ・コーポレーション | 新規なホスホン酸表面改質剤を含む電子デバイス |
| US7960456B2 (en) * | 2009-05-27 | 2011-06-14 | Bromine Compounds Ltd. | Halogenated phosphonates, processes for their preparation and their use as flame retardants |
| WO2011011519A1 (en) | 2009-07-21 | 2011-01-27 | Chimerix, Inc. | Compounds, compositions and methods for treating ocular conditions |
| EP2462152A4 (de) | 2009-08-03 | 2013-02-13 | Chimerix Inc | Zusammensetzung und verfahren zur behandlung von virusinfektionen und durch viren herbeigeführten tumoren |
| US9006218B2 (en) | 2010-02-12 | 2015-04-14 | Chimerix Inc. | Nucleoside phosphonate salts |
| EP2563367A4 (de) | 2010-04-26 | 2013-12-04 | Chimerix Inc | Verfahren zur behandlung von retroviren-infektionen und entsprechende dosierungspläne |
| EP4174077A1 (de) * | 2021-10-27 | 2023-05-03 | Merck Patent GmbH | Elektronische schaltvorrichtung |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2917533A (en) * | 1954-05-12 | 1959-12-15 | Virginia Carolina Chem Corp | Dialkylaminoalkyl esters of phosphonic acid and method of preparing same |
| US3363032A (en) * | 1964-06-11 | 1968-01-09 | Monsanto Co | Long chain aliphatic benzylphosphonic acids, esters and salts |
| DE3339383A1 (de) * | 1983-10-29 | 1985-05-09 | Bayer Ag, 5090 Leverkusen | Distyrylverbindungen |
| US4822780A (en) * | 1987-07-08 | 1989-04-18 | Otsuka Pharmaceutical Factory, Inc. | Carboxamide compounds |
| DE4003054A1 (de) * | 1990-02-02 | 1991-08-08 | Hoechst Ag | Verwendung von benzylphosphonsaeurederivaten zur behandlung von durch viren verursachte krankheiten |
| US5300687A (en) * | 1991-07-18 | 1994-04-05 | Ortho Pharmaceutical Corporation | Trifluoromethylbenzylphosphonates useful in treating osteoporosis |
-
1991
- 1991-07-18 US US07/732,267 patent/US5300687A/en not_active Expired - Lifetime
-
1992
- 1992-07-13 AU AU19656/92A patent/AU657146B2/en not_active Expired - Fee Related
- 1992-07-15 KR KR1019920012631A patent/KR930002364A/ko not_active Application Discontinuation
- 1992-07-16 CA CA002074020A patent/CA2074020A1/en not_active Abandoned
- 1992-07-17 NO NO92922851A patent/NO922851L/no unknown
- 1992-07-17 HU HU9202353A patent/HUT62907A/hu unknown
- 1992-07-17 EP EP92306602A patent/EP0524023A1/de not_active Withdrawn
- 1992-07-17 FI FI923289A patent/FI923289A/fi not_active Application Discontinuation
- 1992-07-17 JP JP4212292A patent/JPH05213977A/ja active Pending
- 1992-07-17 ZA ZA925391A patent/ZA925391B/xx unknown
- 1992-07-17 MX MX9204229A patent/MX9204229A/es unknown
- 1992-07-17 IE IE234192A patent/IE922341A1/en not_active Application Discontinuation
- 1992-07-18 CN CN92109763A patent/CN1070408A/zh not_active Withdrawn
- 1992-08-08 TW TW081106270A patent/TW216796B/zh active
-
1993
- 1993-12-09 US US08/164,602 patent/US5532226A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US5532226A (en) | 1996-07-02 |
| HU9202353D0 (en) | 1992-10-28 |
| MX9204229A (es) | 1993-04-01 |
| AU657146B2 (en) | 1995-03-02 |
| KR930002364A (ko) | 1993-02-23 |
| NO922851L (no) | 1993-01-19 |
| IE922341A1 (en) | 1993-01-27 |
| TW216796B (de) | 1993-12-01 |
| JPH05213977A (ja) | 1993-08-24 |
| CA2074020A1 (en) | 1993-01-19 |
| FI923289A0 (fi) | 1992-07-17 |
| US5300687A (en) | 1994-04-05 |
| FI923289A (fi) | 1993-01-19 |
| EP0524023A1 (de) | 1993-01-20 |
| HUT62907A (en) | 1993-06-28 |
| NO922851D0 (no) | 1992-07-17 |
| AU1965692A (en) | 1993-01-21 |
| CN1070408A (zh) | 1993-03-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ZA925391B (en) | Trifluoromethylbenzylphosphonates useful in treating osteoporosis | |
| GB9219421D0 (en) | Treating waste | |
| GB9100216D0 (en) | Process | |
| GB8905714D0 (en) | Osteoporosis treatment | |
| GB9320897D0 (en) | Compounds useful in anti-allergy treatment | |
| GB9224477D0 (en) | Improvements in bodyforms | |
| GB9211036D0 (en) | Improvements in locking devices | |
| GB2256817B (en) | Improvements in spraying apparatus | |
| GB9124396D0 (en) | Improvements in paddles | |
| GB9103887D0 (en) | Improvements in fastening machines | |
| GB2267654B (en) | Improvements in aerating devices | |
| GB2255871B (en) | Improvements in telecines | |
| GB2268712B (en) | Improvements in life-jackets | |
| GB9113464D0 (en) | Improvements in card-laminating processes | |
| HU913041D0 (en) | Pushdoor in curves | |
| IE883283L (en) | Treating osteoporosis | |
| GB9101326D0 (en) | Improvements in hoisery | |
| GB9318116D0 (en) | Compounds useful in therapy | |
| GB9322864D0 (en) | Compounds useful in therapy | |
| GB9322790D0 (en) | Compounds useful in therapy | |
| IE890791L (en) | Treating osteoporosis | |
| GB9107636D0 (en) | Improvements in cartons | |
| GB9200115D0 (en) | Improvements in impact-delivering apparatus | |
| KR0136265B1 (en) | Microprocessor | |
| GB2264248B (en) | Improvements in surface treatment apparatus |