ZA924107B - Immunomodulatory azaspiranes - Google Patents

Immunomodulatory azaspiranes

Info

Publication number
ZA924107B
ZA924107B ZA924107A ZA924107A ZA924107B ZA 924107 B ZA924107 B ZA 924107B ZA 924107 A ZA924107 A ZA 924107A ZA 924107 A ZA924107 A ZA 924107A ZA 924107 B ZA924107 B ZA 924107B
Authority
ZA
South Africa
Prior art keywords
compounds
azaspiranes
immunomodulatory
immunomodulatory azaspiranes
mammal
Prior art date
Application number
ZA924107A
Other languages
English (en)
Inventor
Alison Mary Badger
Mary Badger Alison
Gary James Bridger
James Bridger Gary
David Aaron Schwartz
Aaron Schwartz David
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of ZA924107B publication Critical patent/ZA924107B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/54—Spiro-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
ZA924107A 1991-06-07 1992-06-05 Immunomodulatory azaspiranes ZA924107B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US71232591A 1991-06-07 1991-06-07

Publications (1)

Publication Number Publication Date
ZA924107B true ZA924107B (en) 1993-04-28

Family

ID=24861652

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA924107A ZA924107B (en) 1991-06-07 1992-06-05 Immunomodulatory azaspiranes

Country Status (15)

Country Link
EP (1) EP0587800B1 (fr)
JP (1) JP3155277B2 (fr)
KR (1) KR100251570B1 (fr)
AT (1) ATE235902T1 (fr)
AU (1) AU665359B2 (fr)
CA (1) CA2110577A1 (fr)
DE (1) DE69232984T2 (fr)
DK (1) DK0587800T3 (fr)
ES (1) ES2191657T3 (fr)
IE (1) IE921827A1 (fr)
MX (1) MX9202713A (fr)
NZ (1) NZ243029A (fr)
PT (1) PT100566B (fr)
WO (1) WO1992022294A1 (fr)
ZA (1) ZA924107B (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9122721D0 (en) * 1991-10-25 1991-12-11 Smithkline Beecham Corp Methods
GB9201804D0 (en) * 1992-01-28 1992-03-11 Smithkline Beecham Corp Methods
GB9217121D0 (en) * 1992-08-13 1992-09-23 Smithkline Beecham Corp Methods
GB9414902D0 (en) * 1994-07-23 1994-09-14 Smithkline Beecham Corp Methods
SK281254B6 (sk) * 1995-07-13 2001-01-18 Smithkline Beecham Corporation Použitie@kán-2-propánamínu, farmaceutický prostriedok s jeho obsahom a jeho použitie
US20110104186A1 (en) 2004-06-24 2011-05-05 Nicholas Valiante Small molecule immunopotentiators and assays for their detection

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0181351A4 (fr) * 1984-05-09 1989-06-21 Univ Australian Procede de modulation de la reaction immunitaire.
US4963557A (en) * 1987-09-28 1990-10-16 Smithkline Beecham Corporation Immunomodulatory azaspiranes
GB9122721D0 (en) * 1991-10-25 1991-12-11 Smithkline Beecham Corp Methods
GB9201804D0 (en) * 1992-01-28 1992-03-11 Smithkline Beecham Corp Methods

Also Published As

Publication number Publication date
IE921827A1 (en) 1992-12-16
DE69232984D1 (de) 2003-05-08
KR100251570B1 (ko) 2000-07-01
DK0587800T3 (da) 2003-07-28
PT100566B (pt) 1999-06-30
ATE235902T1 (de) 2003-04-15
WO1992022294A1 (fr) 1992-12-23
ES2191657T3 (es) 2003-09-16
EP0587800A1 (fr) 1994-03-23
EP0587800A4 (en) 1994-06-29
JPH06508367A (ja) 1994-09-22
EP0587800B1 (fr) 2003-04-02
JP3155277B2 (ja) 2001-04-09
KR940701253A (ko) 1994-05-28
NZ243029A (en) 1994-08-26
CA2110577A1 (fr) 1992-12-23
MX9202713A (es) 1992-12-01
DE69232984T2 (de) 2003-12-18
AU2247992A (en) 1993-01-12
AU665359B2 (en) 1996-01-04
PT100566A (pt) 1993-08-31

Similar Documents

Publication Publication Date Title
ZA921914B (en) Compositions, articles and methods for scavenging oxygen
NZ232621A (en) Benzimidazole and azabenzimidazole derivatives, compositions and intermediate
IL97853A0 (en) Saccharide compositions,methods and apparatus for their synthesis
HK1094148A1 (en) Synergistic therapeutic compositions and methods
AU1462792A (en) Device and method for performing cholangiography
GB9319585D0 (en) Improvements in pharmaceutical compositions
EP0469807A3 (en) Quantum field effect device
IL101042A0 (en) 3-piperidinyl-methylcarboxylate substituted indoles,their preparation and pharmaceutical compositions containing them
EP0596962A4 (en) Therapeutic compositions and methods.
GB9105811D0 (en) Lipopeptide derivatives
ZA911978B (en) Lipopeptide derivatives
HK1011503A1 (en) Immunosuppressive compositions
ZA924107B (en) Immunomodulatory azaspiranes
EP0739119A3 (fr) Appareil pour tampon de mémoire
AU7008494A (en) Methods and compositions for (salmonella)-based vaccines
IL105349A0 (en) Pharmaceutical compositions containing beta-carbolines,methods for the preparation thereof and compounds for use in the preparation thereof
AU2291692A (en) Ciphering device
HK1013350A1 (en) Effect adding apparatus
EP0455904A3 (en) Microbiology sampling device
AU1236392A (en) Device for in vitro testing
IL98065A0 (en) Glycoside derivatives,pharmaceutical compositions containing the same and method for testing for the presence thereof
BG98168U (en) Preservative for oral preparations
GB9005388D0 (en) Pharmaceutical preservative
GB9105157D0 (en) Pharmaceutical preservative
EP0482570A3 (en) Jaw for vices