DK0587800T3 - Immunomodulatoriske azaspiraner - Google Patents
Immunomodulatoriske azaspiranerInfo
- Publication number
- DK0587800T3 DK0587800T3 DK92914312T DK92914312T DK0587800T3 DK 0587800 T3 DK0587800 T3 DK 0587800T3 DK 92914312 T DK92914312 T DK 92914312T DK 92914312 T DK92914312 T DK 92914312T DK 0587800 T3 DK0587800 T3 DK 0587800T3
- Authority
- DK
- Denmark
- Prior art keywords
- azaspirans
- immunomodulatory
- compounds
- mammal
- invented
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/54—Spiro-condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71232591A | 1991-06-07 | 1991-06-07 | |
| PCT/US1992/004834 WO1992022294A1 (en) | 1991-06-07 | 1992-06-05 | Immunomodulatory azaspiranes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0587800T3 true DK0587800T3 (da) | 2003-07-28 |
Family
ID=24861652
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK92914312T DK0587800T3 (da) | 1991-06-07 | 1992-06-05 | Immunomodulatoriske azaspiraner |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0587800B1 (da) |
| JP (1) | JP3155277B2 (da) |
| KR (1) | KR100251570B1 (da) |
| AT (1) | ATE235902T1 (da) |
| AU (1) | AU665359B2 (da) |
| CA (1) | CA2110577A1 (da) |
| DE (1) | DE69232984T2 (da) |
| DK (1) | DK0587800T3 (da) |
| ES (1) | ES2191657T3 (da) |
| IE (1) | IE921827A1 (da) |
| MX (1) | MX9202713A (da) |
| NZ (1) | NZ243029A (da) |
| PT (1) | PT100566B (da) |
| WO (1) | WO1992022294A1 (da) |
| ZA (1) | ZA924107B (da) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9122721D0 (en) * | 1991-10-25 | 1991-12-11 | Smithkline Beecham Corp | Methods |
| GB9201804D0 (en) * | 1992-01-28 | 1992-03-11 | Smithkline Beecham Corp | Methods |
| GB9217121D0 (en) * | 1992-08-13 | 1992-09-23 | Smithkline Beecham Corp | Methods |
| GB9414902D0 (en) * | 1994-07-23 | 1994-09-14 | Smithkline Beecham Corp | Methods |
| SG43383A1 (en) * | 1995-07-13 | 1997-10-17 | Smithkline Beecham Corp | N n-diethyl-8,8-dipropyl-2-azaspiro[4.5]decane-2- propanamine dimaleate |
| CA2571710A1 (en) | 2004-06-24 | 2006-11-02 | Nicholas Valiante | Small molecule immunopotentiators and assays for their detection |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61502124A (ja) * | 1984-05-09 | 1986-09-25 | ジ オ−ストラリアン ナシヨナル ユニヴア−シテイ− | 免疫応答の調節方法 |
| US4963557A (en) * | 1987-09-28 | 1990-10-16 | Smithkline Beecham Corporation | Immunomodulatory azaspiranes |
| GB9122721D0 (en) * | 1991-10-25 | 1991-12-11 | Smithkline Beecham Corp | Methods |
| GB9201804D0 (en) * | 1992-01-28 | 1992-03-11 | Smithkline Beecham Corp | Methods |
-
1992
- 1992-06-04 PT PT100566A patent/PT100566B/pt not_active IP Right Cessation
- 1992-06-05 AU AU22479/92A patent/AU665359B2/en not_active Expired - Fee Related
- 1992-06-05 KR KR1019930703765A patent/KR100251570B1/ko not_active IP Right Cessation
- 1992-06-05 ES ES92914312T patent/ES2191657T3/es not_active Expired - Lifetime
- 1992-06-05 ZA ZA924107A patent/ZA924107B/xx unknown
- 1992-06-05 WO PCT/US1992/004834 patent/WO1992022294A1/en active IP Right Grant
- 1992-06-05 JP JP50097293A patent/JP3155277B2/ja not_active Expired - Fee Related
- 1992-06-05 AT AT92914312T patent/ATE235902T1/de not_active IP Right Cessation
- 1992-06-05 NZ NZ243029A patent/NZ243029A/en unknown
- 1992-06-05 DE DE69232984T patent/DE69232984T2/de not_active Expired - Fee Related
- 1992-06-05 DK DK92914312T patent/DK0587800T3/da active
- 1992-06-05 CA CA002110577A patent/CA2110577A1/en not_active Abandoned
- 1992-06-05 MX MX9202713A patent/MX9202713A/es unknown
- 1992-06-05 EP EP92914312A patent/EP0587800B1/en not_active Expired - Lifetime
- 1992-07-01 IE IE182792A patent/IE921827A1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| WO1992022294A1 (en) | 1992-12-23 |
| AU2247992A (en) | 1993-01-12 |
| ES2191657T3 (es) | 2003-09-16 |
| PT100566A (pt) | 1993-08-31 |
| CA2110577A1 (en) | 1992-12-23 |
| IE921827A1 (en) | 1992-12-16 |
| KR940701253A (ko) | 1994-05-28 |
| ZA924107B (en) | 1993-04-28 |
| DE69232984D1 (de) | 2003-05-08 |
| DE69232984T2 (de) | 2003-12-18 |
| AU665359B2 (en) | 1996-01-04 |
| ATE235902T1 (de) | 2003-04-15 |
| EP0587800A1 (en) | 1994-03-23 |
| MX9202713A (es) | 1992-12-01 |
| NZ243029A (en) | 1994-08-26 |
| PT100566B (pt) | 1999-06-30 |
| EP0587800B1 (en) | 2003-04-02 |
| EP0587800A4 (en) | 1994-06-29 |
| JP3155277B2 (ja) | 2001-04-09 |
| KR100251570B1 (ko) | 2000-07-01 |
| JPH06508367A (ja) | 1994-09-22 |
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