ZA919207B - Process for the reactivation of denatured protein - Google Patents

Process for the reactivation of denatured protein

Info

Publication number
ZA919207B
ZA919207B ZA919207A ZA919207A ZA919207B ZA 919207 B ZA919207 B ZA 919207B ZA 919207 A ZA919207 A ZA 919207A ZA 919207 A ZA919207 A ZA 919207A ZA 919207 B ZA919207 B ZA 919207B
Authority
ZA
South Africa
Prior art keywords
pct
reactivation
protein
denatured protein
sec
Prior art date
Application number
ZA919207A
Other languages
English (en)
Inventor
Dorothea Ambrosius
Ambrosius Dorothea
Rainer Rudolph
Rudolph Rainer
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Publication of ZA919207B publication Critical patent/ZA919207B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1136—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
ZA919207A 1990-11-22 1991-11-21 Process for the reactivation of denatured protein ZA919207B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4037196A DE4037196A1 (de) 1990-11-22 1990-11-22 Verfahren zur reaktivierung von denaturiertem protein

Publications (1)

Publication Number Publication Date
ZA919207B true ZA919207B (en) 1992-08-26

Family

ID=6418742

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA919207A ZA919207B (en) 1990-11-22 1991-11-21 Process for the reactivation of denatured protein

Country Status (17)

Country Link
US (1) US5618927A (fr)
EP (1) EP0512087B1 (fr)
JP (1) JP2572517B2 (fr)
KR (1) KR960013385B1 (fr)
AT (1) ATE149514T1 (fr)
AU (1) AU8919591A (fr)
CA (1) CA2074182C (fr)
DE (2) DE4037196A1 (fr)
DK (1) DK0512087T3 (fr)
ES (1) ES2098379T3 (fr)
GR (1) GR3023110T3 (fr)
HU (1) HU213589B (fr)
IE (1) IE62052B1 (fr)
PT (1) PT99578B (fr)
RU (1) RU2070888C1 (fr)
WO (1) WO1992009622A1 (fr)
ZA (1) ZA919207B (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL109149A0 (en) * 1993-04-01 1994-06-24 Schering Corp In vitro refolding of recombinant fv fragments
US20030133905A1 (en) * 2001-12-20 2003-07-17 Zhenze Hu Composition for treating contact lenses in the eye
SI21273A (sl) * 2002-07-31 2004-02-29 LEK farmacevtska dru�ba d.d. Priprava inkluzijskih teles z visokim deležem pravilno zvitega prekurzorja heterolognega proteina
TWI476207B (zh) * 2006-07-14 2015-03-11 Genentech Inc 重組蛋白之再摺疊
US20160060291A1 (en) * 2012-03-30 2016-03-03 Biogenomics Limited Process for renaturation of polypeptides
WO2014167574A1 (fr) * 2013-03-22 2014-10-16 Biogenomics Limited Procédé pour l'isolation et la stabilisation d'intermédiaires clés pour un repliement à haute efficacité de protéines recombinantes
RU2646103C2 (ru) * 2016-03-30 2018-03-01 Федеральное бюджетное учреждение науки Государственный научный центр прикладной микробиологии и биотехнологии (ФБУН ГНЦ ПМБ) Способ выделения ренатурированного белка g из маркированного полиакриламидного геля

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3537708A1 (de) * 1985-10-23 1987-04-23 Boehringer Mannheim Gmbh Verfahren zur aktivierung von t-pa nach expression in prokaryonten
DE3611817A1 (de) * 1986-04-08 1987-10-15 Boehringer Mannheim Gmbh Verfahren zur renaturierung von proteinen
DE3835350A1 (de) * 1988-10-17 1990-04-19 Boehringer Mannheim Gmbh Aktivierung von gentechnologisch hergestellten, in prokaryonten exprimierten antikoerpern
DE3903581A1 (de) * 1989-02-07 1990-08-16 Boehringer Mannheim Gmbh Gewebs-plasminogenaktivator-derivat

Also Published As

Publication number Publication date
RU2070888C1 (ru) 1996-12-27
ES2098379T3 (es) 1997-05-01
CA2074182C (fr) 1999-10-05
KR960013385B1 (ko) 1996-10-04
US5618927A (en) 1997-04-08
PT99578B (pt) 1999-04-30
EP0512087B1 (fr) 1997-03-05
JP2572517B2 (ja) 1997-01-16
WO1992009622A1 (fr) 1992-06-11
JPH05502245A (ja) 1993-04-22
HU9202354D0 (en) 1992-10-28
DE59108583D1 (de) 1997-04-10
IE913474A1 (en) 1992-06-03
HUT63437A (en) 1993-08-30
DE4037196A1 (de) 1992-05-27
EP0512087A1 (fr) 1992-11-11
AU8919591A (en) 1992-06-25
CA2074182A1 (fr) 1992-05-23
PT99578A (pt) 1992-10-30
DK0512087T3 (da) 1997-08-25
IE62052B1 (en) 1994-12-14
HU213589B (en) 1997-08-28
KR927003623A (ko) 1992-12-18
GR3023110T3 (en) 1997-07-30
ATE149514T1 (de) 1997-03-15

Similar Documents

Publication Publication Date Title
ATE89349T1 (de) Enzymatische behandlung von wolle.
DK83093D0 (da) Fremgangsmaade
DE69117182D1 (de) Kontrollierte abgabe von nährmittel für bakterien und verfahren einer biologischen behandlung
ATE163195T1 (de) Lösliche liganden für cd40
UA6023A1 (uk) Спосіб активізації тканевого активатора плазміногена /його варіанти/
SE9003122D0 (sv) Improvement in solid phase binding assay
DK39693D0 (da) Enzym
ATE198624T1 (de) Expression von albumin in hefe
ATE136052T1 (de) Behandlung von biomasse
DK126693D0 (da) Drikkevare
ZA919207B (en) Process for the reactivation of denatured protein
EP1329461B8 (fr) Procede d'elimination de polymeres d'albumine serique humaine
DE58904713D1 (de) Verwendung von zink- oder eisenhydroxid zur adjuvierung von antigenloesungen und auf diese weise adjuvierte antigenloesungen.
HUT44046A (en) Process for the renaturation of proteins
GR930300084T1 (en) Intermediates for chelating agents with prefixed symmetry and process for their preparation.
MXPA02010643A (es) Un metodo de tratamiento de proteinas de soya y un producto de proteina de soya producido mediante este metodo.
ES2060202T3 (es) Composicion detergente enzimatica liquida.
DE3681008D1 (de) Verfahren zum enzymatischen abbau von restbrot und verwendung des erhaltenen abbauprodukts.
GR930300003T1 (en) Inhibitor of proliferation of endothelial cells.
GB9304399D0 (en) Novel process
DE59611353D1 (de) Transketolase-verwandtes protein
DE69319140D1 (de) 4-guanidinobutyramid zur verbesserung des blutkreislaufs
UA10054A (uk) Спосіб одержання білкового гідролізату
ES2066733A1 (es) Complejo consistente en un activador del plasminogeno y albumina de suero y procedimiento para prepararlo.