ZA918345B - Antibiotic c-3 dithioacetal-substituted carbapenem compounds,compositions and methods of use thereof - Google Patents

Antibiotic c-3 dithioacetal-substituted carbapenem compounds,compositions and methods of use thereof

Info

Publication number
ZA918345B
ZA918345B ZA918345A ZA918345A ZA918345B ZA 918345 B ZA918345 B ZA 918345B ZA 918345 A ZA918345 A ZA 918345A ZA 918345 A ZA918345 A ZA 918345A ZA 918345 B ZA918345 B ZA 918345B
Authority
ZA
South Africa
Prior art keywords
dithioacetal
antibiotic
compositions
methods
carbapenem compounds
Prior art date
Application number
ZA918345A
Other languages
English (en)
Inventor
Alain Martel
Martel Alain
Carol Bachand
Bachand Carol
Jean-Paul Daris
Daris Jean-Paul
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of ZA918345B publication Critical patent/ZA918345B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ZA918345A 1990-10-19 1991-10-18 Antibiotic c-3 dithioacetal-substituted carbapenem compounds,compositions and methods of use thereof ZA918345B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/600,359 US5116833A (en) 1990-10-19 1990-10-19 Antibiotic c-3 dithioacetal-substituted carbapenem compounds, compositions, and methods of use thereof

Publications (1)

Publication Number Publication Date
ZA918345B true ZA918345B (en) 1992-07-29

Family

ID=24403288

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA918345A ZA918345B (en) 1990-10-19 1991-10-18 Antibiotic c-3 dithioacetal-substituted carbapenem compounds,compositions and methods of use thereof

Country Status (10)

Country Link
US (1) US5116833A (fi)
EP (1) EP0481511A3 (fi)
JP (1) JPH04282383A (fi)
AU (1) AU636249B2 (fi)
CA (1) CA2052942A1 (fi)
FI (1) FI95257C (fi)
IE (1) IE913670A1 (fi)
PT (1) PT99285B (fi)
TW (1) TW198723B (fi)
ZA (1) ZA918345B (fi)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5602118A (en) * 1993-03-16 1997-02-11 American Cyanamid Company 2-thiosubstituted carbapenems
EP0976752A1 (en) * 1998-07-28 2000-02-02 Hans Rudolf Prof. Pfaendler C-2 S/O- and S/N-Formaldehyde acetal derivatives of carbapenem antibiotics
CA3152404A1 (en) * 2019-08-29 2021-03-04 The Regents Of The University Of California 8-oxo-1-azbicyclo[4.2.0]oct-2-ene compounds to identify beta-lactamases, and methods of use thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0044170A1 (en) * 1980-07-11 1982-01-20 Beecham Group Plc Beta-lactam antibiotics, their preparation and use
US4552873A (en) * 1981-08-19 1985-11-12 Sankyo Company Limited Carbapenem compounds, and compositions containing them
US4683301A (en) * 1982-04-08 1987-07-28 Bristol-Myers Company Carbapenem antibiotics
CA1285940C (en) * 1984-07-02 1991-07-09 Merck & Co., Inc. Carbapenems having a 2-quaternary heteroarylalkylthio substituent
IE851586L (en) * 1984-07-02 1986-01-02 Interchem Internat S A I methylcarbapenems having a 2-quaternary¹heteroarylalkylthio substituent
CA1273011A (en) * 1984-07-02 1990-08-21 Susan M. Schmitt Carbapenems having an externally alkylated mono- or bicyclic 2-quaternary heteroarylalkylthio substituent
US4880922A (en) * 1985-11-22 1989-11-14 Bristol-Myers Company Carbapenems with quaternized heterothioalkylthio substitution at position 2

Also Published As

Publication number Publication date
IE913670A1 (en) 1992-04-22
PT99285B (pt) 1999-04-30
FI95257C (fi) 1996-01-10
EP0481511A2 (en) 1992-04-22
TW198723B (fi) 1993-01-21
FI914874A (fi) 1992-04-20
CA2052942A1 (en) 1992-04-20
FI914874A0 (fi) 1991-10-16
AU636249B2 (en) 1993-04-22
FI95257B (fi) 1995-09-29
AU8595091A (en) 1992-04-30
JPH04282383A (ja) 1992-10-07
EP0481511A3 (en) 1992-10-28
PT99285A (pt) 1992-08-31
US5116833A (en) 1992-05-26

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