ZA918026B - Acetylenes disubstituted with a phenyl group and a 2-substituted chromanyl,thiochromanyl or 1,2,3,4-tetrahydroquinolinyl group having retinoid-like activity - Google Patents

Acetylenes disubstituted with a phenyl group and a 2-substituted chromanyl,thiochromanyl or 1,2,3,4-tetrahydroquinolinyl group having retinoid-like activity

Info

Publication number
ZA918026B
ZA918026B ZA918026A ZA918026A ZA918026B ZA 918026 B ZA918026 B ZA 918026B ZA 918026 A ZA918026 A ZA 918026A ZA 918026 A ZA918026 A ZA 918026A ZA 918026 B ZA918026 B ZA 918026B
Authority
ZA
South Africa
Prior art keywords
group
thiochromanyl
retinoid
activity
tetrahydroquinolinyl
Prior art date
Application number
ZA918026A
Inventor
Roshantha A S Chandraratna
A S Chandraratna Roshantha
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of ZA918026B publication Critical patent/ZA918026B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/14—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 6 and unsubstituted in position 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/16—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7
ZA918026A 1990-10-09 1991-10-08 Acetylenes disubstituted with a phenyl group and a 2-substituted chromanyl,thiochromanyl or 1,2,3,4-tetrahydroquinolinyl group having retinoid-like activity ZA918026B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US59488290A 1990-10-09 1990-10-09

Publications (1)

Publication Number Publication Date
ZA918026B true ZA918026B (en) 1992-06-24

Family

ID=24380813

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA918026A ZA918026B (en) 1990-10-09 1991-10-08 Acetylenes disubstituted with a phenyl group and a 2-substituted chromanyl,thiochromanyl or 1,2,3,4-tetrahydroquinolinyl group having retinoid-like activity

Country Status (12)

Country Link
EP (1) EP0553156A4 (en)
JP (1) JPH06501948A (en)
AU (1) AU652189B2 (en)
CA (1) CA2092178A1 (en)
FI (1) FI931625A (en)
HU (1) HUT63405A (en)
IE (1) IE913569A1 (en)
IL (1) IL99617A0 (en)
PL (1) PL168679B1 (en)
PT (1) PT99188A (en)
WO (1) WO1992006084A1 (en)
ZA (1) ZA918026B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0571546B1 (en) * 1991-02-13 1996-10-16 Allergan, Inc. Chroman and thiochromans with phenylethynyl substituents at the 7-position having retinoid-like biological activity
FR2691149B1 (en) * 1992-05-18 1994-07-08 Adir NOVEL THIOCHROMANIC COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
US5451603A (en) * 1993-03-11 1995-09-19 Zymogenetics, Inc. 3,4-diarylchromans for treatment of dermatitis
EP0889032A4 (en) * 1996-03-18 2000-01-05 Eisai Co Ltd Fused-ring carboxylic acid derivatives
US6740676B2 (en) * 2002-03-19 2004-05-25 Allergan, Inc. 4-[(8-ethynyl, 8-vinyl or 8-ethynyl-methyl)-6-chromanoyl]-benzoic and 2-[4-[(8-ethynyl, 8-vinyl or 8-ethynyl-methyl)-6-chromanoyl]-phenyl]-acetic acid, their esters and salts having cytochrome p450rai inhibitory activity
EP2453746A4 (en) 2009-07-16 2013-04-24 Stiefel Laboratories Tazarotene derivatives
CN107176945B (en) * 2016-03-11 2021-06-08 中国科学院上海有机化学研究所 Retinoid compound, preparation method, intermediate and application thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4810804A (en) * 1987-03-26 1989-03-07 Allergan, Inc. Acetylenes disubstituted with a phenyl group and a heterobicyclic group having retinoid-like activity
US4980369A (en) * 1989-09-19 1990-12-25 Allergan, Inc. Acetylenes disubstituted with a phenyl group and a 2-substituted chromanyl or thiochromanyl group having retinoid-like activity
EP0571546B1 (en) * 1991-02-13 1996-10-16 Allergan, Inc. Chroman and thiochromans with phenylethynyl substituents at the 7-position having retinoid-like biological activity

Also Published As

Publication number Publication date
CA2092178A1 (en) 1992-04-10
IE913569A1 (en) 1992-04-22
HUT63405A (en) 1993-08-30
FI931625A0 (en) 1993-04-08
FI931625A (en) 1993-06-07
EP0553156A1 (en) 1993-08-04
HU9301030D0 (en) 1993-07-28
EP0553156A4 (en) 1993-11-18
PT99188A (en) 1992-09-30
IL99617A0 (en) 1992-08-18
AU652189B2 (en) 1994-08-18
PL168679B1 (en) 1996-03-29
WO1992006084A1 (en) 1992-04-16
JPH06501948A (en) 1994-03-03
AU8721091A (en) 1992-04-28

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