ZA914958B - 2,4-and 2,5-substituted pyridine-n-oxides,processes for their preparation and their use - Google Patents

2,4-and 2,5-substituted pyridine-n-oxides,processes for their preparation and their use

Info

Publication number
ZA914958B
ZA914958B ZA914958A ZA914958A ZA914958B ZA 914958 B ZA914958 B ZA 914958B ZA 914958 A ZA914958 A ZA 914958A ZA 914958 A ZA914958 A ZA 914958A ZA 914958 B ZA914958 B ZA 914958B
Authority
ZA
South Africa
Prior art keywords
oxides
substituted pyridine
processes
preparation
collagen
Prior art date
Application number
ZA914958A
Inventor
Ekkehard Baader
Baader Ekkehard
Martin Bickel
Bickel Martin
Volkmar Guenzler-Pukall
Guenzler-Pukall Volkmar
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of ZA914958B publication Critical patent/ZA914958B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Transplantation (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

2,4- and 2,5-substituted pyridine N-oxides which have fibrosuppressive and immunosuppressive activity are presented. The said compounds are likewise suitable for the treatment of disturbances of the metabolism of collagen and collagen-like substances and of the biosynthesis of C1q.
ZA914958A 1990-06-28 1991-06-27 2,4-and 2,5-substituted pyridine-n-oxides,processes for their preparation and their use ZA914958B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4020570A DE4020570A1 (en) 1990-06-28 1990-06-28 2,4- AND 2,5-SUBSTITUTED PYRIDINE-N-OXIDES, METHOD FOR THE PRODUCTION AND USE THEREOF

Publications (1)

Publication Number Publication Date
ZA914958B true ZA914958B (en) 1992-03-25

Family

ID=6409247

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA914958A ZA914958B (en) 1990-06-28 1991-06-27 2,4-and 2,5-substituted pyridine-n-oxides,processes for their preparation and their use

Country Status (27)

Country Link
EP (1) EP0463592B1 (en)
JP (1) JPH0832687B2 (en)
KR (1) KR920000724A (en)
CN (1) CN1038585C (en)
AT (1) ATE110059T1 (en)
AU (1) AU636990B2 (en)
BR (1) BR9102699A (en)
CA (1) CA2045868A1 (en)
CZ (1) CZ283782B6 (en)
DE (2) DE4020570A1 (en)
DK (1) DK0463592T3 (en)
EG (1) EG19851A (en)
ES (1) ES2061118T3 (en)
FI (1) FI101070B (en)
HR (1) HRP940701B1 (en)
HU (1) HU214627B (en)
IE (1) IE65300B1 (en)
IL (1) IL98629A (en)
LT (1) LT3918B (en)
MA (1) MA22191A1 (en)
MX (1) MX26415A (en)
MY (1) MY107573A (en)
NO (1) NO178026C (en)
NZ (1) NZ238701A (en)
PT (1) PT98108B (en)
YU (1) YU113391A (en)
ZA (1) ZA914958B (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU9492A (en) * 1991-02-05 1995-03-27 Hoechst Ag. 2,4- and 2,5-BIS-TETRAZOLYL pyridines and the process for their preparation
EP0548883A1 (en) * 1991-12-24 1993-06-30 Hoechst Aktiengesellschaft Substituted pyridine-N-oxides, process for their preparation and their use as medicines
TW352384B (en) * 1992-03-24 1999-02-11 Hoechst Ag Sulfonamido- or sulfonamidocarbonylpyridine-2-carboxamides, process for their preparation and their use as pharmaceuticals
TW222585B (en) * 1992-09-11 1994-04-21 Hoechst Ag
DE4233124A1 (en) * 1992-10-02 1994-04-07 Hoechst Ag Acylsulfonamido and sulfonamidopyridine-2-carboxylic acid esters and their pyridine N-oxides, processes for their preparation and their use as medicaments
DE19624704A1 (en) * 1996-06-20 1998-01-08 Klinge Co Chem Pharm Fab New pyridylalkanoic acid amides
US6451816B1 (en) 1997-06-20 2002-09-17 Klinge Pharma Gmbh Use of pyridyl alkane, pyridyl alkene and/or pyridyl alkine acid amides in the treatment of tumors or for immunosuppression
DE19624659A1 (en) 1996-06-20 1998-01-08 Klinge Co Chem Pharm Fab New pyridylalkene and pyridylalkanoic acid amides
FR2766187B1 (en) * 1997-07-17 2000-06-02 Rhone Poulenc Rorer Sa PYRAZINE DERIVATIVES, THEIR PREPARATION AND THE MEDICINES CONTAINING THEM
DE19756261A1 (en) 1997-12-17 1999-07-01 Klinge Co Chem Pharm Fab New aryl-substituted pyridylalkane, alkene and alkyarboxylic acid amides
DE19756235A1 (en) 1997-12-17 1999-07-01 Klinge Co Chem Pharm Fab New piperidinyl-substituted pyridylalkane alkene and alkane carboxylic acid amides
US6903118B1 (en) 1997-12-17 2005-06-07 Klinge Pharma Gmbh Piperazinyl-substituted pyridylalkane, alkene and alkine carboxamides
DE19756212A1 (en) 1997-12-17 1999-07-01 Klinge Co Chem Pharm Fab New cyclic imide-substituted pyridylalkane, alkene and alkyarboxylic acid amides
EP1031564A1 (en) 1999-02-26 2000-08-30 Klinge Pharma GmbH Inhibitors of cellular nicotinamide mononucleotide formation and their use in cancer therapy
DOP2002000332A (en) 2001-02-14 2002-08-30 Warner Lambert Co MATRIX METALOPROTEINAS PYRIDINE INHIBITORS
DOP2002000328A (en) 2001-02-14 2003-08-30 Warner Lambert Co MATRIX METALOPROTEINASH INHIBITING PYRIMIDINS
DOP2002000333A (en) 2001-02-14 2002-09-30 Warner Lambert Co DERIVATIVES OF ISOFTALIC ACID AS INHIBITORS OF METALOPROTEINASES OF THE MATRIX
US6924276B2 (en) 2001-09-10 2005-08-02 Warner-Lambert Company Diacid-substituted heteroaryl derivatives as matrix metalloproteinase inhibitors
MXPA04002537A (en) 2001-10-12 2004-05-31 Warner Lambert Co Alkyne matrix metalloproteinase inhibitors.
US6933298B2 (en) 2001-12-08 2005-08-23 Aventis Pharma Deutschland Gmbh Pyridine-2,4-dicarboxylic acid diamides and pyrimidine-4,6-dicarboxylic acid diamides and the use thereof for selectively inhibiting collagenases
DE10160357A1 (en) * 2001-12-08 2003-06-18 Aventis Pharma Gmbh Use of pyridine-2,4-dicarboxylic acid diamides and pyrimidine-4,6-dicarboxylic acid diamides for the selective inhibition of collagenases

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5623987B2 (en) * 1972-02-04 1981-06-03
JPS6052702B2 (en) 1976-08-27 1985-11-20 中外製薬株式会社 Pyridine derivatives and their manufacturing method
JPS57109792A (en) * 1980-12-26 1982-07-08 Banyu Pharmaceut Co Ltd Penicillin derivative and salt thereof
DE3432094A1 (en) 1984-08-31 1986-03-06 Hoechst Ag, 6230 Frankfurt ESTER OF PYRIDINE-2,4- AND -2,5-DICARBONIC ACID AS A MEDICINAL PRODUCT FOR INHIBITING PROLIN AND LYSINE HYDROXYLASE
JP2512924B2 (en) * 1987-01-21 1996-07-03 萬有製薬株式会社 Hair restorer
DE3703959A1 (en) 1987-02-10 1988-08-18 Hoechst Ag PYRIDINE-2,4- AND 2,5-DICARBONIC ACID AMIDES, METHOD FOR THE PRODUCTION THEREOF, USE OF THE SAME AND MEDICINAL PRODUCTS BASED ON THESE COMPOUNDS
DE3703963A1 (en) * 1987-02-10 1988-08-18 Hoechst Ag PYRIDINE-2,4- AND 2,, 5-DICARBONIC ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, USE THEREOF, AND MEDICINAL PRODUCTS BASED ON THESE COMPOUNDS
DE3703962A1 (en) 1987-02-10 1988-08-18 Hoechst Ag PYRIDINE-2,4- AND 2,5-DICARBONIC ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, USE OF THE SAME AND MEDICINAL PRODUCTS BASED ON THESE COMPOUNDS
JP2600786B2 (en) * 1988-04-12 1997-04-16 萬有製薬株式会社 Hair restorer
DE3826471A1 (en) 1988-08-04 1990-02-22 Hoechst Ag Improved process for the preparation of N,N'-bis(alkoxyalkyl)pyridine-2,4-dicarboximides
DE3924093A1 (en) 1989-07-20 1991-02-07 Hoechst Ag N, N'-BIS (ALKOXY-ALKYL) -PYRIDINE-2,4-DICARBONESAUREDIAMIDES, METHOD FOR THE PRODUCTION AND USE THEREOF
ZA91291B (en) 1990-01-16 1991-09-25 Hoechst Ag Di(nitroxyalkyl)amides of pyridine-2,4-and-2,5-dicarboxylic acids,a process for the preparation thereof,and the use thereof

Also Published As

Publication number Publication date
MA22191A1 (en) 1991-12-31
IE912253A1 (en) 1992-01-01
EP0463592A1 (en) 1992-01-02
AU636990B2 (en) 1993-05-13
HRP940701B1 (en) 1999-08-31
HRP940701A2 (en) 1997-02-28
NO912541D0 (en) 1991-06-27
FI101070B (en) 1998-04-15
DK0463592T3 (en) 1994-12-19
ATE110059T1 (en) 1994-09-15
BR9102699A (en) 1992-02-04
HU214627B (en) 1998-04-28
EP0463592B1 (en) 1994-08-17
CA2045868A1 (en) 1991-12-29
JPH04230264A (en) 1992-08-19
LT3918B (en) 1996-04-25
IL98629A0 (en) 1992-07-15
LTIP1464A (en) 1995-05-25
FI913118A0 (en) 1991-06-26
CS195991A3 (en) 1992-02-19
CN1038585C (en) 1998-06-03
IL98629A (en) 1996-05-14
ES2061118T3 (en) 1994-12-01
HU912158D0 (en) 1991-12-30
KR920000724A (en) 1992-01-29
MY107573A (en) 1996-04-30
EG19851A (en) 1996-10-31
AU7935691A (en) 1992-01-02
IE65300B1 (en) 1995-10-18
NZ238701A (en) 1994-06-27
JPH0832687B2 (en) 1996-03-29
NO178026B (en) 1995-10-02
MX26415A (en) 1993-05-01
NO178026C (en) 1996-01-10
NO912541L (en) 1991-12-30
CN1057649A (en) 1992-01-08
YU113391A (en) 1995-10-03
PT98108A (en) 1993-06-30
CZ283782B6 (en) 1998-06-17
FI913118A (en) 1991-12-29
HUT59104A (en) 1992-04-28
PT98108B (en) 1998-12-31
DE4020570A1 (en) 1992-01-02
DE59102547D1 (en) 1994-09-22

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