ZA906544B - 5-methyl-isoxazole-4-carboxylic acid anilides and 2-hydroxyethylidene-cyano acetic acid anilides for the treatment of ocular diseases - Google Patents
5-methyl-isoxazole-4-carboxylic acid anilides and 2-hydroxyethylidene-cyano acetic acid anilides for the treatment of ocular diseasesInfo
- Publication number
- ZA906544B ZA906544B ZA906544A ZA906544A ZA906544B ZA 906544 B ZA906544 B ZA 906544B ZA 906544 A ZA906544 A ZA 906544A ZA 906544 A ZA906544 A ZA 906544A ZA 906544 B ZA906544 B ZA 906544B
- Authority
- ZA
- South Africa
- Prior art keywords
- acid anilides
- hydroxyethylidene
- isoxazole
- methyl
- treatment
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Ophthalmology & Optometry (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39586089A | 1989-08-18 | 1989-08-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA906544B true ZA906544B (en) | 1991-06-26 |
Family
ID=23564835
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA906544A ZA906544B (en) | 1989-08-18 | 1990-08-17 | 5-methyl-isoxazole-4-carboxylic acid anilides and 2-hydroxyethylidene-cyano acetic acid anilides for the treatment of ocular diseases |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0413329B1 (cs) |
| JP (1) | JP3131693B2 (cs) |
| KR (1) | KR100192745B1 (cs) |
| AT (1) | ATE148628T1 (cs) |
| AU (1) | AU633346B2 (cs) |
| CA (1) | CA2023560C (cs) |
| DD (1) | DD297328A5 (cs) |
| DE (1) | DE69029884T2 (cs) |
| DK (1) | DK0413329T3 (cs) |
| ES (1) | ES2099700T3 (cs) |
| HU (1) | HU215959B (cs) |
| IE (1) | IE902978A1 (cs) |
| IL (1) | IL95412A (cs) |
| TW (1) | TW287948B (cs) |
| ZA (1) | ZA906544B (cs) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0538783B1 (de) * | 1991-10-23 | 1995-09-27 | Hoechst Aktiengesellschaft | N-phenyl-2-cyano-3-hydroxycrotonsäureamidderivate und deren Verwendung als Arzneimittel mit immunmodulatorischer Eigenschaft |
| TW314467B (cs) * | 1993-03-31 | 1997-09-01 | Hoechst Ag | |
| US5610173A (en) * | 1994-01-07 | 1997-03-11 | Sugen, Inc. | Formulations for lipophilic compounds |
| US6335356B1 (en) | 1994-01-07 | 2002-01-01 | Sugen, Inc. | Method of treating a patient by parenteral administration of a lipophilic compound |
| US5700823A (en) * | 1994-01-07 | 1997-12-23 | Sugen, Inc. | Treatment of platelet derived growth factor related disorders such as cancers |
| HU222888B1 (hu) * | 1994-10-17 | 2003-12-29 | Hoechst Pharmaceuticals & Chemicals K.K. | Anilid vegyületek alkalmazása I típusú allergiás betegségek megelőzésére és kezelésére alkalmas gyógyszerkészítmények előállítására |
| US5721277A (en) * | 1995-04-21 | 1998-02-24 | Sugen, Inc. | Compounds and methods for inhibiting hyper-proliferative cell growth |
| US6331555B1 (en) | 1995-06-01 | 2001-12-18 | University Of California | Treatment of platelet derived growth factor related disorders such as cancers |
| US6011051A (en) * | 1996-07-31 | 2000-01-04 | Hoechst Aktiengesellschaft | Use of isoxazole and crotonamide derivatives for the modulation of apoptosis |
| US6316479B1 (en) | 1997-05-19 | 2001-11-13 | Sugen, Inc. | Isoxazole-4-carboxamide compounds active against protein tryosine kinase related disorders |
| DE102006017896A1 (de) † | 2006-04-13 | 2007-10-25 | Tiefenbacher Pharmachemikalien Alfred E. Tiefenbacher Gmbh & Co. Kg | Leflunomid enthaltende pharmazeutische Zusammensetzungen |
| EP3139914B1 (en) * | 2014-05-08 | 2023-07-26 | Kiora Pharmaceuticals GmbH | Compounds for treating ophthalmic diseases and disorders |
| CN119095831A (zh) * | 2022-03-25 | 2024-12-06 | 瓦斯塞拉股份有限公司 | 3-苯基异噁唑衍生物和含有其作为活性成分的用于预防或治疗眼部疾病的药物组合物 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES448386A1 (es) | 1975-06-05 | 1978-04-16 | Hoechst Ag | Procedimiento para la preparacion de anilidas de acido 5-me-til-isoxazol-4-carboxilico. |
| NL186239B (nl) * | 1975-06-05 | Hoechst Ag | Werkwijze voor de bereiding van een geneesmiddel met antiflogistische en/of analgetische werking, alsmede werkwijze voor de bereiding van een 2-hydroxyethylideencyaanazijnzuuranilide geschikt voor toepassing bij deze werkwijze. | |
| DE2854439A1 (de) * | 1978-12-16 | 1980-07-03 | Hoechst Ag | Ein isoxazolderivat, verfahren zu seiner herstellung, diese verbindung enthaltende mittel und verwendung |
| DE3534440A1 (de) * | 1985-09-27 | 1987-04-02 | Hoechst Ag | Arzneimittel gegen chronische graft-versus-host-krankheiten sowie gegen autoimmunerkrankungen, insbesondere systemischen lupus erythematodes |
| GB8619432D0 (en) * | 1986-08-08 | 1986-09-17 | Lilly Industries Ltd | Pharmaceutical compounds |
-
1990
- 1990-08-15 DD DD90343461A patent/DD297328A5/de unknown
- 1990-08-16 DE DE69029884T patent/DE69029884T2/de not_active Expired - Fee Related
- 1990-08-16 EP EP90115691A patent/EP0413329B1/en not_active Expired - Lifetime
- 1990-08-16 DK DK90115691.9T patent/DK0413329T3/da active
- 1990-08-16 AT AT90115691T patent/ATE148628T1/de not_active IP Right Cessation
- 1990-08-16 ES ES90115691T patent/ES2099700T3/es not_active Expired - Lifetime
- 1990-08-16 JP JP02215129A patent/JP3131693B2/ja not_active Expired - Fee Related
- 1990-08-16 KR KR1019900012602A patent/KR100192745B1/ko not_active Expired - Fee Related
- 1990-08-17 ZA ZA906544A patent/ZA906544B/xx unknown
- 1990-08-17 CA CA002023560A patent/CA2023560C/en not_active Expired - Fee Related
- 1990-08-17 IL IL9541290A patent/IL95412A/en not_active IP Right Cessation
- 1990-08-17 IE IE297890A patent/IE902978A1/en not_active IP Right Cessation
- 1990-08-17 AU AU61104/90A patent/AU633346B2/en not_active Ceased
- 1990-08-17 HU HU905064A patent/HU215959B/hu not_active IP Right Cessation
- 1990-08-17 TW TW081106491A patent/TW287948B/zh active
Also Published As
| Publication number | Publication date |
|---|---|
| EP0413329A3 (en) | 1992-04-15 |
| DD297328A5 (de) | 1992-01-09 |
| ES2099700T3 (es) | 1997-06-01 |
| CA2023560A1 (en) | 1991-02-19 |
| ATE148628T1 (de) | 1997-02-15 |
| JP3131693B2 (ja) | 2001-02-05 |
| EP0413329B1 (en) | 1997-02-05 |
| TW287948B (cs) | 1996-10-11 |
| IL95412A (en) | 1996-01-31 |
| KR910004193A (ko) | 1991-03-28 |
| JPH0390024A (ja) | 1991-04-16 |
| IE902978A1 (en) | 1991-02-27 |
| AU6110490A (en) | 1991-02-21 |
| DK0413329T3 (da) | 1997-08-18 |
| DE69029884D1 (de) | 1997-03-20 |
| HU905064D0 (en) | 1991-01-28 |
| HUT59600A (en) | 1992-06-29 |
| KR100192745B1 (ko) | 1999-06-15 |
| IL95412A0 (en) | 1991-06-30 |
| HU215959B (hu) | 1999-03-29 |
| CA2023560C (en) | 2000-12-12 |
| EP0413329A2 (en) | 1991-02-20 |
| AU633346B2 (en) | 1993-01-28 |
| DE69029884T2 (de) | 1997-08-14 |
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