ZA903859B - Dimeric epipodophyllotoxin glucoside derivatives - Google Patents

Dimeric epipodophyllotoxin glucoside derivatives

Info

Publication number
ZA903859B
ZA903859B ZA903859A ZA903859A ZA903859B ZA 903859 B ZA903859 B ZA 903859B ZA 903859 A ZA903859 A ZA 903859A ZA 903859 A ZA903859 A ZA 903859A ZA 903859 B ZA903859 B ZA 903859B
Authority
ZA
South Africa
Prior art keywords
dimeric
glucoside derivatives
epipodophyllotoxin glucoside
epipodophyllotoxin
derivatives
Prior art date
Application number
ZA903859A
Other languages
English (en)
Inventor
Mark G Saulnier
G Saulnier Mark
David R Langley
R Langley David
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of ZA903859B publication Critical patent/ZA903859B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
ZA903859A 1989-05-19 1990-05-18 Dimeric epipodophyllotoxin glucoside derivatives ZA903859B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/354,956 US4965348A (en) 1989-05-19 1989-05-19 Dimeric epipodophyllotoxin glucoside derivatives

Publications (1)

Publication Number Publication Date
ZA903859B true ZA903859B (en) 1991-01-30

Family

ID=23395617

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA903859A ZA903859B (en) 1989-05-19 1990-05-18 Dimeric epipodophyllotoxin glucoside derivatives

Country Status (9)

Country Link
US (1) US4965348A (pt)
EP (1) EP0398367A3 (pt)
JP (1) JPH035494A (pt)
KR (1) KR920002141B1 (pt)
AU (1) AU625211B2 (pt)
CA (1) CA2013425A1 (pt)
FI (1) FI902428A0 (pt)
PT (1) PT94091A (pt)
ZA (1) ZA903859B (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5034380A (en) * 1989-11-20 1991-07-23 Bristol-Myers Squibb Company Alkoxymethylidene epipodophyllotoxin glucosides
IT1250692B (it) * 1991-07-23 1995-04-21 Procedimento per la preparazione di demetilepipodofillotossina- beta-d-glucosidi.
US5463040A (en) * 1994-06-28 1995-10-31 Teva Pharmaceutical Industries, Ltd. Method of preparing etoposide
JP3441284B2 (ja) * 1995-03-14 2003-08-25 高砂香料工業株式会社 光学活性アミンの製造方法
ES2185801T3 (es) * 1995-09-29 2003-05-01 Japan Science & Tech Corp Nuevos derivados de compuestos de antraciclina y preparaciones farmaceuticas que los contienen.
US6207673B1 (en) 1997-03-12 2001-03-27 The University Of North Carolina At Chapel Hill Covalent conjugates of topoisomerase I and topoisomerase II inhibitors
US6051721A (en) * 1997-10-02 2000-04-18 The Board Of Regents Of The University Of Nebraska Ring E-modified analogues of(-)-podophyllotoxin and etoposide and a method for their synthesis
CA2385528C (en) 1999-10-01 2013-12-10 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
US7342114B2 (en) * 2003-07-01 2008-03-11 California Pacific Medical Center Podophyllotoxin derivatives
JP6550538B2 (ja) 2015-10-27 2019-07-24 カリフォルニア パシフィック メディカル センター ポドフィロトキシン誘導体およびそれらの使用
US10087194B2 (en) 2015-10-27 2018-10-02 California Pacific Medical Center Podophyllotoxin derivatives and their use

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL6613143A (pt) * 1965-09-21 1967-03-22
CH507934A (de) * 1965-12-14 1971-05-31 Sandoz Ag Verfahren zur Herstellung eines neuen Glucosids
US4567253A (en) * 1984-02-03 1986-01-28 Tony Durst 2-Substituted derivatives of podophyllotoxin and etoposide
US4609644A (en) * 1984-06-15 1986-09-02 St. Jude Children's Research Hospital Epipodophyllotoxinquinone glucoside derivatives, method of production and use
JPS61227590A (ja) * 1985-04-02 1986-10-09 Microbial Chem Res Found 新規４′−デメチル−４−エピポドフイロトキシン誘導体
JPS63150293A (ja) * 1986-12-12 1988-06-22 Nippon Kayaku Co Ltd エトポシド水溶性誘導体
US4916217A (en) * 1987-01-08 1990-04-10 Bristol-Myers Company Phosphorus containing derivatives of epipodophyllotoxin
US4853467A (en) * 1987-05-19 1989-08-01 Bristol-Myers Company Nitrogen containing derivatives of epipodophyllotoxin glucosides
US4874851A (en) * 1987-07-01 1989-10-17 Bristol-Meyers Company 3',4'-dinitrogen substituted epipodophyllotoxin glucoside derivatives
US4904768A (en) * 1987-08-04 1990-02-27 Bristol-Myers Company Epipodophyllotoxin glucoside 4'-phosphate derivatives
US4868291A (en) * 1987-08-20 1989-09-19 Bristol-Myers Company 4'-deshydroxyepipodophyllotoxin glucosides: synthesis and use
US4888419A (en) * 1987-08-31 1989-12-19 Bristol-Myers Company 3'-demethoxyepipodophyllotoxin glucoside derivatives
ZA886810B (en) * 1987-12-18 1989-08-30 Bristol Myers Co Epipodophyllotoxin glucoside 4'-acyl derivatives
US4912204A (en) * 1988-09-06 1990-03-27 Bristol-Myers Company Fluoro-substituted epipodophyllotoxin glucosides
CN1042362A (zh) * 1988-10-31 1990-05-23 布里斯托尔-米尔斯公司 表鬼臼脂素糖苷的磷酸和磺酸酯的制备方法

Also Published As

Publication number Publication date
AU625211B2 (en) 1992-07-02
PT94091A (pt) 1991-01-08
FI902428A0 (fi) 1990-05-16
KR900018131A (ko) 1990-12-20
KR920002141B1 (ko) 1992-03-12
EP0398367A3 (en) 1991-04-10
CA2013425A1 (en) 1990-11-19
EP0398367A2 (en) 1990-11-22
JPH035494A (ja) 1991-01-11
US4965348A (en) 1990-10-23
AU5518390A (en) 1990-11-22

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