ZA902150B - Benzazepine and benzothiazepine derivatives - Google Patents

Benzazepine and benzothiazepine derivatives

Info

Publication number
ZA902150B
ZA902150B ZA902150A ZA902150A ZA902150B ZA 902150 B ZA902150 B ZA 902150B ZA 902150 A ZA902150 A ZA 902150A ZA 902150 A ZA902150 A ZA 902150A ZA 902150 B ZA902150 B ZA 902150B
Authority
ZA
South Africa
Prior art keywords
benzazepine
benzothiazepine derivatives
benzothiazepine
derivatives
Prior art date
Application number
ZA902150A
Other languages
English (en)
Inventor
Joel Charles Barrish
Charles Barrish Joel
Spencer David Kimball
David Kimball Spencer
John Krapcho
Krapcho John
Original Assignee
Squibb & Sons Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc
Publication of ZA902150B publication Critical patent/ZA902150B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA902150A 1989-04-06 1990-03-20 Benzazepine and benzothiazepine derivatives ZA902150B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/334,025 US4946840A (en) 1989-04-06 1989-04-06 Benzazepine and benzothiazepine derivatives

Publications (1)

Publication Number Publication Date
ZA902150B true ZA902150B (en) 1990-12-28

Family

ID=23305246

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA902150A ZA902150B (en) 1989-04-06 1990-03-20 Benzazepine and benzothiazepine derivatives

Country Status (9)

Country Link
US (1) US4946840A (xx)
EP (1) EP0391414A3 (xx)
JP (1) JPH02290856A (xx)
AU (1) AU631408B2 (xx)
CA (1) CA2012603A1 (xx)
HU (1) HU205757B (xx)
NZ (1) NZ232937A (xx)
PT (1) PT93668A (xx)
ZA (1) ZA902150B (xx)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6555139B2 (en) 1999-06-28 2003-04-29 Wockhardt Europe Limited Preparation of micron-size pharmaceutical particles by microfluidization
US20050043551A1 (en) * 2001-09-28 2005-02-24 Olazabal Manso Ervelio Eliseo Method of obtaining 2-(2-nitrovinyl)-furan and the use thereof as a coccidiostatic
WO2005035505A2 (en) * 2003-09-30 2005-04-21 Artesian Therapeutics, Inc. Compounds with phosphodiesterase inhibiting and calcium channel blocking activities
CA2734780C (en) * 2008-08-22 2016-07-05 Milestone Pharmaceuticals Inc. Short acting benzothiazepine calcium channel blockers and uses thereof

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3562257A (en) * 1967-10-28 1971-02-09 Tanabe Seiyaku Co Benzothiazepine derivatives
US4567175A (en) * 1983-06-03 1986-01-28 Tanabe Seiyaku Co., Ltd. 8-Chloro-1,5-benzothiazepine derivatives
US4590188A (en) * 1984-02-18 1986-05-20 Tanabe Seiyaku Co., Ltd. 1,5-benzothiazepine derivatives and their pharmaceutical use
US4748239A (en) * 1985-06-12 1988-05-31 E. R. Squibb & Sons, Inc. Benzazepine derivatives
CA1271747C (en) * 1985-06-12 1990-07-17 BENZAZEPINE DERIVATIVES
US4584131A (en) * 1985-06-20 1986-04-22 E. R. Squibb & Sons, Inc. Benzothiazepine derivatives
DE3717561A1 (de) * 1987-05-25 1988-12-08 Thomae Gmbh Dr K Indol-, isochinolin- und benzazepinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
CA1271748C (en) * 1985-12-12 1990-07-17 BENZAZEPINE DERIVATIVES
EP0256888B1 (en) * 1986-08-20 1991-07-03 McNeilab, Inc. Benzothiazepine vasodilators having aralkyl substitution
US4694002A (en) * 1986-08-21 1987-09-15 E. R. Squibb & Sons, Inc. Benzothiazepine derivatives
US4752645A (en) * 1986-10-09 1988-06-21 E. R. Squibb & Sons, Inc. Benzazepine derivatives
US4774239A (en) * 1987-08-26 1988-09-27 E. R. Squibb & Sons, Inc. Benzazepine derivatives
US4902684A (en) * 1988-06-20 1990-02-20 E. R. Squibb & Sons, Inc. Benzazepine and benzothiazepine derivatives
US5001236A (en) * 1989-11-22 1991-03-19 Marion Laboratories, Inc. Benzothiazepines

Also Published As

Publication number Publication date
PT93668A (pt) 1990-11-20
HUT53635A (en) 1990-11-28
HU902101D0 (en) 1990-08-28
EP0391414A2 (en) 1990-10-10
CA2012603A1 (en) 1990-10-06
NZ232937A (en) 1992-09-25
AU631408B2 (en) 1992-11-26
HU205757B (en) 1992-06-29
EP0391414A3 (en) 1991-03-13
JPH02290856A (ja) 1990-11-30
AU5206690A (en) 1990-10-11
US4946840A (en) 1990-08-07

Similar Documents

Publication Publication Date Title
ZA908446B (en) Use of a benzodiazepine and phenylpyrrylketone derivative
GB2231329B (en) Benzazepine and benzothiazepine derivatives
NZ235270A (en) Diazepinone derivatives and pharmaceutical compositions
ZA898741B (en) Use of azepinone derivatives
HRP931011A2 (en) Benzothiazepine and benzoxazepine derivatives
ZA902148B (en) Benzazepine derivatives
ZA902150B (en) Benzazepine and benzothiazepine derivatives
NZ235269A (en) Diazepinone derivatives and pharmaceutical compositions
ZA894315B (en) Benzazepine and benzothiazepine derivatives
DK296790D0 (da) Benzazepin- og benzothiazepinderivater
IE901094L (en) Benzazepines and benzothiazepines
IE900963L (en) Benzazepines and benzothiazepines
IE893670L (en) Use of azepinone derivatives
GB8912055D0 (en) Thiazepine derivatives
GB8921077D0 (en) Thiazepine derivatives
GB8925403D0 (en) Thiazepine derivatives
ZA894427B (en) Benzazepine derivatives
IL92606A0 (en) Sphingenine and derivatives thereof
DE3990664T1 (de) Benzazepin- und benzothiazepin-derivate
ZA901443B (en) Aminoethylthiazole and aminoethyloxazole derivatives
IE893644L (en) Benzodiazepine derivatives
IE892089L (en) Benzodiazepine derivatives
IE890198L (en) Dibenzo and pyridobenzazepinones
IL101562A0 (en) Benzodiazepine derivatives
GB8823660D0 (en) Benzodiazepine derivatives