ZA899556B - A rapidly cleavable substrate for hiv protease - Google Patents

A rapidly cleavable substrate for hiv protease

Info

Publication number
ZA899556B
ZA899556B ZA899556A ZA899556A ZA899556B ZA 899556 B ZA899556 B ZA 899556B ZA 899556 A ZA899556 A ZA 899556A ZA 899556 A ZA899556 A ZA 899556A ZA 899556 B ZA899556 B ZA 899556B
Authority
ZA
South Africa
Prior art keywords
hiv protease
thr
ile
val
cleavable substrate
Prior art date
Application number
ZA899556A
Other languages
English (en)
Inventor
Karin Moelling
Moelling Karin
Stephan Henke
Henke Stephan
Gerhard Breipohl
Breipohl Gerhard
Wolfgang Koenig
Koenig Wolfgang
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of ZA899556B publication Critical patent/ZA899556B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
    • C12N2740/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G01N2333/15—Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus, feline leukaemia virus, human T-cell leukaemia-lymphoma virus
    • G01N2333/155—Lentiviridae, e.g. visna-maedi virus, equine infectious virus, FIV, SIV
    • G01N2333/16—HIV-1, HIV-2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ZA899556A 1988-12-15 1989-12-14 A rapidly cleavable substrate for hiv protease ZA899556B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3842197A DE3842197A1 (de) 1988-12-15 1988-12-15 Rasch spaltbares substrat fuer die hiv-protease

Publications (1)

Publication Number Publication Date
ZA899556B true ZA899556B (en) 1990-09-26

Family

ID=6369209

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA899556A ZA899556B (en) 1988-12-15 1989-12-14 A rapidly cleavable substrate for hiv protease

Country Status (16)

Country Link
US (1) US5093477A (no)
EP (1) EP0373576B1 (no)
JP (1) JPH02207097A (no)
KR (1) KR900009694A (no)
AT (1) ATE120205T1 (no)
AU (1) AU4614889A (no)
CA (1) CA2005516A1 (no)
DE (2) DE3842197A1 (no)
DK (1) DK634389A (no)
ES (1) ES2070886T3 (no)
FI (1) FI895950A0 (no)
GR (1) GR3015740T3 (no)
IL (1) IL92687A0 (no)
NO (1) NO895027L (no)
PT (1) PT92574A (no)
ZA (1) ZA899556B (no)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0428000A1 (en) * 1989-11-03 1991-05-22 Abbott Laboratories Fluorogenic substrates for the detection of proteolytic enzyme activity
US5235039A (en) * 1991-06-10 1993-08-10 Eli Lilly And Company Substrates for hiv protease
US5554728A (en) * 1991-07-23 1996-09-10 Nexstar Pharmaceuticals, Inc. Lipid conjugates of therapeutic peptides and protease inhibitors
US6825169B1 (en) 1991-10-22 2004-11-30 Trustees Of Tufts College Inhibitors of dipeptidyl-aminopeptidase type IV
US6071895A (en) * 1992-03-11 2000-06-06 Narhex Limited Polar-substituted hydrocarbons
ATE253050T1 (de) 1992-03-11 2003-11-15 Narhex Ltd Aminderivate von oxo- und hydroxy- substituierten kohlenwasserstoffen
US5888992A (en) * 1992-03-11 1999-03-30 Narhex Limited Polar substituted hydrocarbons
EP0633881B1 (en) * 1992-03-11 2003-10-29 Narhex Limited Amine derivatives of oxo- and hydroxy-substitued hydrocarbons
US5965532A (en) 1996-06-28 1999-10-12 Trustees Of Tufts College Multivalent compounds for crosslinking receptors and uses thereof
US6100234A (en) * 1997-05-07 2000-08-08 Tufts University Treatment of HIV
US6040145A (en) * 1997-05-07 2000-03-21 Tufts University Potentiation of the immune response
AU743996B2 (en) 1997-09-29 2002-02-14 Point Therapeutics, Inc. Stimulation of hematopoietic cells in vitro
KR20010052302A (ko) 1998-05-04 2001-06-25 바바라 피. 월너 조혈 자극
EP1084129B1 (en) 1998-06-05 2003-01-22 Point Therapeutics, Inc. Cyclic boroproline compounds
US6979697B1 (en) * 1998-08-21 2005-12-27 Point Therapeutics, Inc. Regulation of substrate activity
US6890904B1 (en) 1999-05-25 2005-05-10 Point Therapeutics, Inc. Anti-tumor agents
US20060014697A1 (en) * 2001-08-22 2006-01-19 Travis Mickle Pharmaceutical compositions for prevention of overdose or abuse
US20040077601A1 (en) * 2002-07-09 2004-04-22 Point Therapeutics, Inc. Methods and compositions relating to isoleucine boroproline compounds
US20060063719A1 (en) * 2004-09-21 2006-03-23 Point Therapeutics, Inc. Methods for treating diabetes

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1293591C (en) * 1985-01-11 1991-12-24 Charles A. Kettner Peptide substrates for detecting virus-specified protease activity
DE3643012A1 (de) * 1986-12-17 1988-06-30 Hoechst Ag 2,3-disubstituierte isoxazolidine, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung
DE3736589A1 (de) * 1987-10-29 1989-05-11 Behringwerke Ag Glutaminhaltige peptide, verfahren zu deren herstellung und verwendung
US5011910A (en) * 1989-12-28 1991-04-30 Washington University Reagent and method for determining activity of retroviral protease

Also Published As

Publication number Publication date
EP0373576A3 (en) 1990-10-31
DE58909130D1 (de) 1995-04-27
CA2005516A1 (en) 1990-06-15
NO895027D0 (no) 1989-12-14
ES2070886T3 (es) 1995-06-16
FI895950A0 (fi) 1989-12-13
ATE120205T1 (de) 1995-04-15
GR3015740T3 (en) 1995-07-31
JPH02207097A (ja) 1990-08-16
US5093477A (en) 1992-03-03
EP0373576B1 (de) 1995-03-22
EP0373576A2 (de) 1990-06-20
DK634389D0 (da) 1989-12-14
NO895027L (no) 1990-06-18
KR900009694A (ko) 1990-07-05
PT92574A (pt) 1990-06-29
DK634389A (da) 1990-06-16
AU4614889A (en) 1990-06-21
IL92687A0 (en) 1990-09-17
DE3842197A1 (de) 1990-06-21

Similar Documents

Publication Publication Date Title
IL92687A0 (en) Rapidly cleavable substrate for hiv protease
Bode et al. The refined 1.9 A crystal structure of human alpha‐thrombin: interaction with D‐Phe‐Pro‐Arg chloromethylketone and significance of the Tyr‐Pro‐Pro‐Trp insertion segment.
Akahane et al. Three-dimensional structure of human renin.
ATE108438T1 (de) Urethan geschützte aminosäuren-n- carboxyanhydride.
GB1488987A (en) Chromogenic enzyme substrates
DK135887D0 (da) Human-vaevstype-plasminogenaktivator-polypeptider og fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende disse
Atlas The active site of porcine elastase
AU4678589A (en) Use of peptide isosteres as retroviral protease inhibitors
Segal et al. The stereochemistry of substrate binding to chymotrypsin Aγ
DE3462039D1 (en) Peptide derivatives, their preparation and use as elastase inhibitors
EP0498784A3 (en) Inhibitors of retroviral protease
DK0583338T3 (da) Fremgangsmåde til syntese af peptider, hidtil ukendte aminosyrederivater anvendt i denne fremgangsmåde og fremgangsmåder til deres fremstilling
GB8906156D0 (en) Production and use of anthelmintic agents and protective immunogens
IL102615A (en) Immunoassy kit for simultaneously detecting antibodies to hiv-1, hiv-2, htlv-1 and htlv-ii and methods for te detections of antibodies
DE3751398D1 (de) Substrat-Peptide.
US6159746A (en) Solid phase immunoassay to detect inhibitors of proteolytic enzymes
Chaiken et al. A solid phase synthetic study of structure-function relationships in the amino-terminal region of staphylococcal nuclease
Lalmanach et al. Interaction between cystatin-derived peptides and papain
DE3665462D1 (en) Pharmacologically active peptides
KR890012001A (ko) 사람 α2-플라스민 억제제 또는 이와 유사한 단백질로 부터 유도된 단백질
NO982227D0 (no) Urogenitalcarcinom-TPL komplekspeptider og antistoffer derav
DK362288D0 (da) Homocyclostatin- og cyclostatinholdige peptider og farmaceutiske praeparater indeholdende disse
NO175593C (no) Fremgangsmåte for fastfase-peptidsyntese
NO922229L (no) Peptid derivativ, fremgangsmaate til fremstilling av dissefarmasoeytiske preparater som inneholder disse og fremgangsmaate for behandling av glaucoma
KR910004663A (ko) 정신-약리학적 펩티드