ZA896504B - 3-(aminopropyl)methyl phosphinic acid as a therapeutic agent - Google Patents

3-(aminopropyl)methyl phosphinic acid as a therapeutic agent

Info

Publication number
ZA896504B
ZA896504B ZA896504A ZA896504A ZA896504B ZA 896504 B ZA896504 B ZA 896504B ZA 896504 A ZA896504 A ZA 896504A ZA 896504 A ZA896504 A ZA 896504A ZA 896504 B ZA896504 B ZA 896504B
Authority
ZA
South Africa
Prior art keywords
aminopropyl
phosphinic acid
therapeutic agent
methyl phosphinic
methyl
Prior art date
Application number
ZA896504A
Other languages
English (en)
Inventor
Judith Mary Hills
Mary Hills Judith
William Howson
Howson William
Original Assignee
Smith Kline French Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith Kline French Lab filed Critical Smith Kline French Lab
Publication of ZA896504B publication Critical patent/ZA896504B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/5537—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom the heteroring containing the structure -C(=O)-N-C(=O)- (both carbon atoms belong to the heteroring)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/301—Acyclic saturated acids which can have further substituents on alkyl

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ZA896504A 1988-08-26 1989-08-25 3-(aminopropyl)methyl phosphinic acid as a therapeutic agent ZA896504B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888820266A GB8820266D0 (en) 1988-08-26 1988-08-26 Compounds

Publications (1)

Publication Number Publication Date
ZA896504B true ZA896504B (en) 1992-07-29

Family

ID=10642740

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA896504A ZA896504B (en) 1988-08-26 1989-08-25 3-(aminopropyl)methyl phosphinic acid as a therapeutic agent

Country Status (13)

Country Link
EP (1) EP0356128B1 (enExample)
JP (1) JPH03502101A (enExample)
AT (1) ATE77747T1 (enExample)
AU (1) AU614668B2 (enExample)
DE (1) DE68901961T2 (enExample)
DK (1) DK101990A (enExample)
ES (1) ES2043025T3 (enExample)
GB (1) GB8820266D0 (enExample)
GR (1) GR3005094T3 (enExample)
IE (1) IE892738L (enExample)
PT (1) PT91525B (enExample)
WO (1) WO1990001936A1 (enExample)
ZA (1) ZA896504B (enExample)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5457095A (en) * 1984-10-12 1995-10-10 Ciba-Geigy Corporation Substituted propane-phosponous acid compounds
US5243062A (en) * 1984-10-12 1993-09-07 Ciba-Geigy Corporation Substituted propane-phosphonous acid compounds
GB8728483D0 (en) * 1987-12-04 1988-01-13 Ciba Geigy Ag Chemical compounds
US5190933A (en) * 1987-12-04 1993-03-02 Ciba-Geigy Corporation Substituted propane-phosphinic acid compounds
US5300679A (en) * 1987-12-04 1994-04-05 Ciba-Geigy Corporation Substituted propane-phosphinic acid compounds
US5567840A (en) * 1989-05-13 1996-10-22 Ciba-Geigy Corporation Substituted aminoalkylphosphinic acids
GB8911017D0 (en) * 1989-05-13 1989-06-28 Ciba Geigy Ag Substituted aminoalkylphosphinic acids
US5281747A (en) * 1989-05-13 1994-01-25 Ciba-Geigy Corporation Substituted aminoalkylphosphinic acids
GB8912814D0 (en) * 1989-06-03 1989-07-19 Ciba Geigy Ag P-substituted propane-phospinic acid compounds
US5190934A (en) * 1989-06-03 1993-03-02 Ciba-Geigy Corporation P-subsituted propane-phosphinic acid compounds
IL98502A (en) * 1990-06-22 1998-04-05 Ciba Geigy Ag Aminoalkane phosphinic acid derivatives, process for their preparation and pharmaceutical compositions containing them
EP0767174A1 (de) * 1991-11-21 1997-04-09 Ciba-Geigy Ag Neue Aminoalkanphosphinsäuren und ihre Salze
AU662404B2 (en) * 1992-05-08 1995-08-31 Novartis Ag Novel N-aralkyl- and N-heteroaralkyl-aminoalkanephosphinic acids
GB9308430D0 (en) * 1993-04-23 1993-06-09 Glaxo Group Ltd Medicaments
SE9603408D0 (sv) * 1996-09-18 1996-09-18 Astra Ab Medical use
SE9904507D0 (sv) 1999-12-09 1999-12-09 Astra Ab New compounds
SE9904508D0 (sv) 1999-12-09 1999-12-09 Astra Ab New compounds
US7319095B2 (en) 1999-12-09 2008-01-15 Astrazeneca Ab Use of GABAB receptor agonists
AR033779A1 (es) 2001-06-08 2004-01-07 Astrazeneca Ab Compuestos utiles en la enfermedad de reflujo
GB0327186D0 (en) * 2003-11-21 2003-12-24 Novartis Ag Organic compounds
PT1691811E (pt) 2003-12-11 2014-10-30 Sunovion Pharmaceuticals Inc Combinação de um sedativo e de um modulador de neurotransmissores e métodos para melhorar a qualidade do sono e tratamento da depressão
SE0401653D0 (sv) 2004-06-24 2004-06-24 Astrazeneca Ab New compounds
EP2275096A3 (en) 2005-08-26 2011-07-13 Braincells, Inc. Neurogenesis via modulation of the muscarinic receptors
EP2258357A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
WO2007047978A2 (en) 2005-10-21 2007-04-26 Braincells, Inc. Modulation of neurogenesis by pde inhibition
EP2314289A1 (en) 2005-10-31 2011-04-27 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
AU2006327317B2 (en) 2005-12-23 2010-11-25 Astrazeneca Ab GABA-B receptor modulators
AU2006327315A1 (en) 2005-12-23 2007-06-28 Astrazeneca Ab Imidazole derivatives for the treatment of gastrointestinal disorders
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
US7678808B2 (en) 2006-05-09 2010-03-16 Braincells, Inc. 5 HT receptor mediated neurogenesis
EP2021000A2 (en) 2006-05-09 2009-02-11 Braincells, Inc. Neurogenesis by modulating angiotensin
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
WO2011113904A1 (en) 2010-03-17 2011-09-22 INSERM (Institut National de la Santé et de la Recherche Médicale) Medicaments for the prevention and treatment of a disease associated with retinal ganglion cell degeneration
CN107050456B (zh) 2010-09-28 2022-08-12 加利福尼亚大学董事会 治疗代谢综合征相关疾病的gaba激动剂和治疗或预防i型糖尿病的gaba组合

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2032712C3 (de) * 1970-07-02 1978-10-19 Bayer Ag, 5090 Leverkusen Verfahren zur Herstellung von w-Amino-alkanphosphonsäure bzw.- phosphinsäurederivaten
GB8425872D0 (en) * 1984-10-12 1984-11-21 Ciba Geigy Ag Chemical compounds

Also Published As

Publication number Publication date
EP0356128B1 (en) 1992-07-01
PT91525A (pt) 1990-03-08
GR3005094T3 (enExample) 1993-05-24
DE68901961T2 (de) 1992-12-24
DE68901961D1 (en) 1992-08-06
AU614668B2 (en) 1991-09-05
WO1990001936A1 (en) 1990-03-08
DK101990D0 (da) 1990-04-25
PT91525B (pt) 1995-05-04
JPH03502101A (ja) 1991-05-16
ATE77747T1 (de) 1992-07-15
ES2043025T3 (es) 1993-12-16
AU4204389A (en) 1990-03-23
EP0356128A3 (en) 1990-06-13
EP0356128A2 (en) 1990-02-28
GB8820266D0 (en) 1988-09-28
IE892738L (en) 1990-02-26
DK101990A (da) 1990-04-25

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