ZA895333B - 2-indolones substituted in 5 by a cyclic hydrazide radical,their preparation and their use in cardio-active medicaments - Google Patents

2-indolones substituted in 5 by a cyclic hydrazide radical,their preparation and their use in cardio-active medicaments

Info

Publication number
ZA895333B
ZA895333B ZA895333A ZA895333A ZA895333B ZA 895333 B ZA895333 B ZA 895333B ZA 895333 A ZA895333 A ZA 895333A ZA 895333 A ZA895333 A ZA 895333A ZA 895333 B ZA895333 B ZA 895333B
Authority
ZA
South Africa
Prior art keywords
indolones
cardio
substituted
preparation
active medicaments
Prior art date
Application number
ZA895333A
Other languages
English (en)
Inventor
Guy Nadler
Nadler Guy
Michel Martin
Martin Michel
Richard Zimmermann
Zimmermann Richard
Original Assignee
Beecham Lab Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Lab Sa filed Critical Beecham Lab Sa
Publication of ZA895333B publication Critical patent/ZA895333B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA895333A 1988-07-15 1989-07-13 2-indolones substituted in 5 by a cyclic hydrazide radical,their preparation and their use in cardio-active medicaments ZA895333B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888816944A GB8816944D0 (en) 1988-07-15 1988-07-15 Compounds

Publications (1)

Publication Number Publication Date
ZA895333B true ZA895333B (en) 1990-06-27

Family

ID=10640552

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA895333A ZA895333B (en) 1988-07-15 1989-07-13 2-indolones substituted in 5 by a cyclic hydrazide radical,their preparation and their use in cardio-active medicaments

Country Status (10)

Country Link
US (1) US5051417A (xx)
EP (1) EP0351213A3 (xx)
JP (1) JPH02142787A (xx)
KR (1) KR900001694A (xx)
AU (1) AU3810989A (xx)
DK (1) DK348289A (xx)
GB (1) GB8816944D0 (xx)
IE (1) IE892276L (xx)
PT (1) PT91164A (xx)
ZA (1) ZA895333B (xx)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU614965B2 (en) * 1987-06-06 1991-09-19 Merck Patent Gesellschaft Mit Beschrankter Haftung Thiadiazinones
DE19502699A1 (de) * 1995-01-28 1996-08-01 Merck Patent Gmbh Arylalkyl-thiadiazinone
US6147106A (en) 1997-08-20 2000-11-14 Sugen, Inc. Indolinone combinatorial libraries and related products and methods for the treatment of disease
US6906093B2 (en) 1995-06-07 2005-06-14 Sugen, Inc. Indolinone combinatorial libraries and related products and methods for the treatment of disease
US5880141A (en) * 1995-06-07 1999-03-09 Sugen, Inc. Benzylidene-Z-indoline compounds for the treatment of disease
DE19533975A1 (de) * 1995-09-14 1997-03-20 Merck Patent Gmbh Arylalkyl-diazinone
US20040067531A1 (en) * 1997-08-20 2004-04-08 Sugen, Inc. Methods of modulating protein tyrosine kinase function with substituted indolinone compounds
GB9718913D0 (en) * 1997-09-05 1997-11-12 Glaxo Group Ltd Substituted oxindole derivatives
US6531502B1 (en) 1998-01-21 2003-03-11 Sugen, Inc. 3-Methylidenyl-2-indolinone modulators of protein kinase
US6569868B2 (en) 1998-04-16 2003-05-27 Sugen, Inc. 2-indolinone derivatives as modulators of protein kinase activity
JP2002531498A (ja) * 1998-12-04 2002-09-24 ニューロサーチ、アクティーゼルスカブ イオンチャネル活性剤としてのイサチン誘導体の使用方法
US6492398B1 (en) 1999-03-04 2002-12-10 Smithkline Beechman Corporation Thiazoloindolinone compounds
GB9904933D0 (en) 1999-03-04 1999-04-28 Glaxo Group Ltd Compounds
US6624171B1 (en) * 1999-03-04 2003-09-23 Smithkline Beecham Corporation Substituted aza-oxindole derivatives
CZ303705B6 (cs) * 2000-02-15 2013-03-27 Sugen, Inc. Pyrrolem substituovaná 2-indolinonová sloucenina pro pouzití jako inhibitor proteinkináz a farmaceutická kompozice s jejím obsahem
US6620818B1 (en) 2000-03-01 2003-09-16 Smithkline Beecham Corporation Method for reducing the severity of side effects of chemotherapy and/or radiation therapy
MXPA02010759A (es) * 2000-05-02 2004-07-30 Sugen Inc Derivados del acido (2-oxindol-3-ilidenil) acetico y su uso como inhibidores de la proteina quinasa.
MY128450A (en) 2000-05-24 2007-02-28 Upjohn Co 1-(pyrrolidin-1-ylmethyl)-3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives
WO2001094312A2 (en) * 2000-06-02 2001-12-13 Sugen, Inc. Indolinone derivatives as protein kinase/phosphatase inhibitors
AR042586A1 (es) 2001-02-15 2005-06-29 Sugen Inc 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa
PE20030062A1 (es) 2001-05-30 2003-02-08 Sugen Inc Derivados aralquilsulfonil-3-(pirrol-2-ilmetiliden)-2-indolinona como inhibidores de quinasas
AR038957A1 (es) * 2001-08-15 2005-02-02 Pharmacia Corp Terapia de combinacion para el tratamiento del cancer
CA2462950A1 (en) 2001-10-10 2003-04-17 Sugen, Inc. 3-[4-(substituted heterocyclyl)-pyrrol-2-ylmethylidene]-2-indolinone derivatives as kinase inhibitors
US20030119839A1 (en) * 2001-12-13 2003-06-26 Nan-Horng Lin Protein kinase inhibitors
DE10254304A1 (de) * 2002-11-21 2004-06-03 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Xanthinderivate, deren Herstellung und deren Verwendung als Arzneimittel
WO2005118551A2 (en) * 2004-05-28 2005-12-15 Ligand Pharmaceuticals Inc. Thrombopoietin activity modulating compounds and methods
BRPI0516883A (pt) * 2004-10-25 2008-09-23 Ligand Pharm Inc compostos e métodos para modulação da atividade de trombopoietina
AU2007225115A1 (en) * 2006-03-15 2007-09-20 Ligand Pharmaceuticals Incorporated Synthesis of thrombopoietin activity modulating compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA853440B (en) * 1984-05-14 1986-12-30 Lilly Co Eli Indoline and 2-indolinone derivatives
JPS61106574A (ja) * 1984-10-29 1986-05-24 Yoshitomi Pharmaceut Ind Ltd オキサ（またはチア）ジアジン誘導体
GB8518422D0 (en) * 1985-07-22 1985-08-29 Beecham Group Plc Compounds
DE3631085A1 (de) * 1986-09-12 1988-03-24 Boehringer Mannheim Gmbh Heterocyclisch substituierte indolinone, verfahren zu ihrer herstellung, arzneimittel sowie zwischenprodukte
EP0303418A3 (en) * 1987-08-11 1990-11-07 Smithkline Beecham Laboratoires Pharmaceutiques Substituted indolones, useful in the treatment of heart or asthmatic diseases

Also Published As

Publication number Publication date
DK348289D0 (da) 1989-07-13
US5051417A (en) 1991-09-24
DK348289A (da) 1990-01-16
KR900001694A (ko) 1990-02-27
PT91164A (pt) 1990-02-08
GB8816944D0 (en) 1988-08-17
EP0351213A2 (en) 1990-01-17
AU3810989A (en) 1990-01-18
IE892276L (en) 1990-01-15
JPH02142787A (ja) 1990-05-31
EP0351213A3 (en) 1990-09-05

Similar Documents

Publication Publication Date Title
ZA895333B (en) 2-indolones substituted in 5 by a cyclic hydrazide radical,their preparation and their use in cardio-active medicaments
AP8900136A0 (en) Medicaments
IL81895A0 (en) N-pyridyloxyphenyl-isothioureas,their preparation and their use in pest control
GR900300044T1 (en) Use of monosubstitute selenium compounds in the preparation of a pharmaceutical, pharmaceutical and preparation thereof
GB8915499D0 (en) Medicaments
IL92281A0 (en) Polyimidesiloxanes,their preparation and use
ZA895271B (en) ((4-piperidyl)methyl)-2,3-dihydro-1h-isoindole and-2,3,4,5-tetrahydro-1h-benzazepine derivatives,their preparation and their application in therapy
GB8805269D0 (en) Medicaments
GB8805268D0 (en) Medicaments
ZA897532B (en) Basic 4-aryl-dhp amides,processes for their preparation and their use in medicaments
NZ229274A (en) 1,2-dithiol-3-thion-s-oxides and liver-protective medicaments
IL85451A (en) 26, 27-mono- and 14,15:26,27-diepoxy g22-ll-f28249 derivatives and their pesticidal use
EP0416754A3 (en) A novel substituted pyrazine, formulations thereof and use in medicine
ZA896675B (en) Medicaments
ZA893374B (en) Hydrazinocarbonyloxylabdanes,a process for their preparation and their use as medicaments
NZ230921A (en) 3-phenyloxymethyl-cephalosporin derivatives and medicaments
GB8808599D0 (en) Medicaments
ZA858249B (en) 1,4-dihydropyridine-hydroxyamines,a process for their preparation and their use in medicaments
GB8820650D0 (en) Medicaments
EP0352083A3 (en) Alkenyltetrazole derivatives, their preparation and use
ZA929626B (en) Cephalosporins containing in position 7 a substituted benzyloxyimino radical, their preparation process and their use as medicaments
GB8814725D0 (en) Medicaments
ZA919790B (en) Substituted dibenz-oxa-thioconocnes,-12-oxides and 12,12-dioxides,a process for their preparation and their use in medicaments
IL89036A0 (en) Azolylmethylsilanes,their preparation and their use as fungicides
IL85375A0 (en) Cyclic peptides,their preparation and their use