ZA893374B - Hydrazinocarbonyloxylabdanes,a process for their preparation and their use as medicaments - Google Patents

Hydrazinocarbonyloxylabdanes,a process for their preparation and their use as medicaments

Info

Publication number
ZA893374B
ZA893374B ZA893374A ZA893374A ZA893374B ZA 893374 B ZA893374 B ZA 893374B ZA 893374 A ZA893374 A ZA 893374A ZA 893374 A ZA893374 A ZA 893374A ZA 893374 B ZA893374 B ZA 893374B
Authority
ZA
South Africa
Prior art keywords
hydrazinocarbonyloxylabdanes
medicaments
preparation
Prior art date
Application number
ZA893374A
Other languages
English (en)
Inventor
Raymond Walter Kosley Jr
Walter Kosley Raymond Jr
Gerard J O'malley
J O'malley Gerard
Original Assignee
Hoechst Roussel Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Publication of ZA893374B publication Critical patent/ZA893374B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/24—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/92—Naphthopyrans; Hydrogenated naphthopyrans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D497/10—Spiro-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA893374A 1988-05-09 1989-05-08 Hydrazinocarbonyloxylabdanes,a process for their preparation and their use as medicaments ZA893374B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/191,457 US4883793A (en) 1988-05-09 1988-05-09 Hydrazinocarbonyloxylabdanes for treating cardiac failure

Publications (1)

Publication Number Publication Date
ZA893374B true ZA893374B (en) 1989-12-27

Family

ID=22705575

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA893374A ZA893374B (en) 1988-05-09 1989-05-08 Hydrazinocarbonyloxylabdanes,a process for their preparation and their use as medicaments

Country Status (10)

Country Link
US (1) US4883793A (xx)
EP (1) EP0341571A1 (xx)
JP (1) JPH01319474A (xx)
KR (1) KR900018063A (xx)
AU (1) AU609980B2 (xx)
DK (1) DK225189A (xx)
HU (1) HU205924B (xx)
IL (1) IL90219A0 (xx)
PT (1) PT90486A (xx)
ZA (1) ZA893374B (xx)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3737353A1 (de) * 1987-11-04 1989-05-18 Hoechst Ag Neue acyllabdan-derivate, ein verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
JPH0482885A (ja) * 1990-07-23 1992-03-16 Nippon Kayaku Co Ltd ６―アシル―７―デアセチルフォルスコリン誘導体の新規な製造法
RU2034840C1 (ru) * 1990-07-24 1995-05-10 Хехст АГ СПОСОБ ПОЛУЧЕНИЯ ПРОИЗВОДНЫХ 6-бета-(3-ЗАМЕЩЕННОГО АМИНО)-ПРОПИОНИЛОКСИ-7-ДИАЦЕТИЛФОРСКОЛИНА ИЛИ ИХ ФАРМАЦЕВТИЧЕСКИ ПРИЕМЛЕМЫХ СОЛЕЙ
CN113226304B (zh) * 2018-12-29 2023-03-24 上海明隽生物技术有限公司 免疫抑制药物组合物及其应用

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3631039A (en) * 1969-04-21 1971-12-28 Hoffmann La Roche 2-amino ethyl-2-hydroxy - 6-vinyl tetrahydropyrans tautomers and optical enantiomers thereof
DE2557784C2 (de) * 1975-12-22 1986-04-17 Hoechst Ag, 6230 Frankfurt Forskolin, Verfahren zu dessen Gewinnung und diese Verbindung enthaltende pharmazeutische Präparate
DE2640275A1 (de) * 1976-09-08 1978-03-09 Hoechst Ag Pharmakologisch wirksame substanz aus labiaten
DE2654796A1 (de) * 1976-12-03 1978-06-08 Hoechst Ag Polyoxygenierte labdan-derivate
US4517200A (en) * 1982-12-27 1985-05-14 Schering-Plough Corporation Method for treating allergic reactions with forskolin
US4564626A (en) * 1983-04-01 1986-01-14 Schering Corporation Methods of inducing bronchodilation
DE3314999A1 (de) * 1983-04-26 1985-03-14 Behringwerke Ag, 3550 Marburg Verwendung des diterpen-derivates forskolin zur immunstimulation
US4476140A (en) * 1983-05-16 1984-10-09 Yale University Composition and method for treatment of glaucoma
DE3407514A1 (de) * 1984-03-01 1985-09-26 Hoechst Ag, 6230 Frankfurt Verwendung von polyoxygenierten labdanderivaten zur behandlung von konstriktionen der atemwege
US4680811A (en) * 1984-12-13 1987-07-14 Veeco Integrated Automation Inc. Vehicle to fixed station infrared communications link
DE3502686A1 (de) * 1985-01-26 1986-08-14 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von labdan-derivaten und ihre verwendung als arzneimittel
US4672115A (en) * 1984-12-14 1987-06-09 Hoechst-Roussel Pharmaceuticals Inc. Process for preparing aminoacyllabdanes
EP0191166B1 (en) * 1984-12-14 1991-02-06 Hoechst-Roussel Pharmaceuticals Incorporated Aminoacyllabdanes, a process and intermediates for their preparation and their use as medicaments
US4666904A (en) * 1984-12-14 1987-05-19 Hoechst-Roussel Pharmaceuticals Inc. Aminoacyllabdanes, pharmacuetical compositions and use
US4673752A (en) * 1984-12-14 1987-06-16 Hoechst-Roussel Pharmaceuticals Inc. Aminoacyllabdanes
DE3502685A1 (de) * 1985-01-26 1986-09-04 Hoechst Ag, 6230 Frankfurt Forskolin, seine analoge und derivate, verfahren zu deren herstellung mittels mikrobieller umwandlungen und die anwendung dieser verbindungen als arzneimittel
US4639446A (en) * 1984-12-14 1987-01-27 Hoechst-Roussel Pharmaceuticals Inc. Aminoacyllabdanes, pharmaceutical compositions and use
EP0193132B1 (en) * 1985-03-01 1991-04-17 Hoechst-Roussel Pharmaceuticals Incorporated Labdan-derivatives, a process for their preparation and their use as medicaments
US4677103A (en) * 1985-03-01 1987-06-30 Hoechst-Roussel Pharmaceuticals Inc. Labdane compounds, pharmaceutical compositions and use
US4639443A (en) * 1985-03-01 1987-01-27 Hoechst-Roussel Pharmaceuticals Inc. Labdane compounds, pharmaceutical compositions and use
IN163242B (xx) * 1985-05-03 1988-08-27 Hoechst India
DE3623300A1 (de) * 1986-07-11 1988-01-21 Hoechst Ag 7-acyloxy-6-aminoacyloxypolyoxylabdane, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
FI875699A (fi) * 1986-12-29 1988-06-30 Hoechst Roussel Pharma Nya karbamoyloxilabdaner, mellanprodukter och foerfaranden foer deras framstaellning samt deras anvaendning saosom laekemedel.

Also Published As

Publication number Publication date
DK225189D0 (da) 1989-05-08
US4883793A (en) 1989-11-28
JPH01319474A (ja) 1989-12-25
DK225189A (da) 1989-11-10
AU609980B2 (en) 1991-05-09
HUT50808A (en) 1990-03-28
KR900018063A (ko) 1990-12-20
IL90219A0 (en) 1989-12-15
PT90486A (pt) 1989-11-30
EP0341571A1 (en) 1989-11-15
AU3452189A (en) 1989-11-09
HU205924B (en) 1992-07-28

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