ZA887410B - Polyamine derivatives as antineoplastic agents - Google Patents

Polyamine derivatives as antineoplastic agents

Info

Publication number
ZA887410B
ZA887410B ZA887410A ZA887410A ZA887410B ZA 887410 B ZA887410 B ZA 887410B ZA 887410 A ZA887410 A ZA 887410A ZA 887410 A ZA887410 A ZA 887410A ZA 887410 B ZA887410 B ZA 887410B
Authority
ZA
South Africa
Prior art keywords
hydrogen
treatment
polyamine derivatives
relates
antineoplastic agents
Prior art date
Application number
ZA887410A
Other languages
English (en)
Inventor
Nellikunja J Prakash
J Prakash Nellikunja
David M Stemerick
M Stemerick David
Michael L Edwards
L Edwards Michael
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of ZA887410B publication Critical patent/ZA887410B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C211/14—Amines containing amino groups bound to at least two aminoalkyl groups, e.g. diethylenetriamines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ZA887410A 1987-10-08 1988-10-03 Polyamine derivatives as antineoplastic agents ZA887410B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10619787A 1987-10-08 1987-10-08

Publications (1)

Publication Number Publication Date
ZA887410B true ZA887410B (en) 1989-06-28

Family

ID=22310050

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA887410A ZA887410B (en) 1987-10-08 1988-10-03 Polyamine derivatives as antineoplastic agents

Country Status (10)

Country Link
EP (1) EP0311068B1 (fr)
JP (1) JPH01128962A (fr)
KR (1) KR0130977B1 (fr)
AT (1) ATE103585T1 (fr)
AU (1) AU608373B2 (fr)
DE (1) DE3888778T2 (fr)
DK (1) DK562488A (fr)
ES (1) ES2053668T3 (fr)
IE (1) IE61846B1 (fr)
ZA (1) ZA887410B (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5091576A (en) * 1986-12-02 1992-02-25 University Of Florida Anti-neoplastic, anti-viral or anti-retroviral spermine derivatives
US5109024A (en) * 1987-02-03 1992-04-28 Merrell Dow Pharmaceuticals Inc. Polyamine derivatives as antineoplastic agents
US5753714A (en) * 1987-02-03 1998-05-19 Merrell Pharmaceuticals Inc. Polyamine derivatives
CA1338764C (fr) * 1987-02-03 1996-12-03 David M. Stemerick Derives de polyamine
ATE120447T1 (de) * 1989-01-10 1995-04-15 Merrell Dow Pharma Polyamin-derivate als antineoplastische mittel.
US5561136A (en) * 1990-12-13 1996-10-01 Merrell Pharmaceuticals Inc. Method of treating cancer by conjunctive therapy with N,N'-bis[ethylamino)propyl]-1,7-heptanediamine and a cytotoxic agent
US5354782A (en) * 1991-01-17 1994-10-11 Merrell Dow Pharmaceuticals Inc. Polyamine phenols as radioprotective agents
US5217964A (en) * 1991-01-23 1993-06-08 Merrell Dow Pharmaceuticals Inc. Polyamine thiols as radioprotective agents
HUT74005A (en) * 1993-02-23 1996-10-28 Merrell Pharma Inc Polyamine derivatives as radioprotective agents and pharmaceutical compositions containing them
WO1995009832A1 (fr) * 1993-10-07 1995-04-13 Merrell Dow Pharmaceuticals Inc. Nouveau procede de preparation de derives de polyamine et leurs intermediaires
EP0955044B1 (fr) * 1995-06-26 2005-11-16 Chelator LLC Procédé pour empêcher la croissance bactérienne ou fongique comportant un agent complexant
WO2003013245A1 (fr) 2001-08-07 2003-02-20 Wisconsin Alumni Research Foundation Polyamines et analogues assurant une protection des cellules a l'occasion des chimiotherapies et radiotherapies anticancereuses
BRPI0614805A2 (pt) * 2005-08-10 2011-04-12 Univ Johns Hopkins poliaminas úteis como produtos terapêuticos antiparasìticos e anticáncer e como inibidores de demetilase lisina-especìficos
EP2190404A1 (fr) * 2007-09-18 2010-06-02 Fujifilm Manufacturing Europe B.V. Composés absorbant les uv

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57192340A (en) * 1981-05-18 1982-11-26 Nisshin Flour Milling Co Ltd Isoprenylamine derivative
US4507321A (en) * 1982-02-17 1985-03-26 The Research Foundation Of State University Of New York Epithelial cell growth regulating composition containing polyamines and a method of using same
NZ212053A (en) * 1984-05-17 1988-02-29 Merrell Dow Pharma Polyamine containing pharmaceutical compositions for treating neoplasms
ZA853602B (en) * 1984-05-17 1985-12-24 Merrell Dow Pharma Method for the treatment of neoplasms
GB8419103D0 (en) * 1984-07-26 1984-08-30 Beecham Wuelfing Gmbh & Co Kg Compounds
CA1305425C (fr) * 1986-12-02 1992-07-21 Raymond J. Bergeron Derive de la spermine ayant un effet anti-cancereux
CA1338764C (fr) * 1987-02-03 1996-12-03 David M. Stemerick Derives de polyamine

Also Published As

Publication number Publication date
ES2053668T3 (es) 1994-08-01
ATE103585T1 (de) 1994-04-15
IE883048L (en) 1989-04-08
DE3888778T2 (de) 1994-07-14
DK562488A (da) 1989-04-09
EP0311068B1 (fr) 1994-03-30
DE3888778D1 (de) 1994-05-05
JPH01128962A (ja) 1989-05-22
KR0130977B1 (ko) 1998-04-16
AU2347088A (en) 1989-04-13
KR890006228A (ko) 1989-06-12
EP0311068A3 (en) 1990-06-13
DK562488D0 (da) 1988-10-07
IE61846B1 (en) 1994-11-30
AU608373B2 (en) 1991-03-28
EP0311068A2 (fr) 1989-04-12

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