ZA885546B - 8-trifluoromethyl quinolones as antibacterial agents - Google Patents
8-trifluoromethyl quinolones as antibacterial agentsInfo
- Publication number
- ZA885546B ZA885546B ZA885546A ZA885546A ZA885546B ZA 885546 B ZA885546 B ZA 885546B ZA 885546 A ZA885546 A ZA 885546A ZA 885546 A ZA885546 A ZA 885546A ZA 885546 B ZA885546 B ZA 885546B
- Authority
- ZA
- South Africa
- Prior art keywords
- quinolones
- trifluoromethyl
- antibacterial agents
- antibacterial
- agents
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/083,532 US4780468A (en) | 1987-08-07 | 1987-08-07 | 8-trifluoromethyl quinolones as antibacterial agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA885546B true ZA885546B (en) | 1990-03-28 |
Family
ID=22178934
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA885546A ZA885546B (en) | 1987-08-07 | 1988-07-28 | 8-trifluoromethyl quinolones as antibacterial agents |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4780468A (xx) |
| EP (1) | EP0302525A3 (xx) |
| JP (1) | JPS6466180A (xx) |
| KR (1) | KR890003735A (xx) |
| AU (2) | AU616422B2 (xx) |
| DK (1) | DK439688A (xx) |
| FI (1) | FI883628A (xx) |
| NO (1) | NO883475L (xx) |
| NZ (1) | NZ225626A (xx) |
| PH (1) | PH24784A (xx) |
| PT (1) | PT88203A (xx) |
| ZA (1) | ZA885546B (xx) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI88506C (fi) * | 1986-07-04 | 1993-05-25 | Chemie Linz Gmbh | Foerfarande foer framstaellning av farmaceutiskt anvaendbar 7-diazabicykloalkyl-6-fluor-1-(2,4-difluorfenyl)-1,4-dihydro-4-oxo-kinolin-3-karboxylsyra eller karboxylsyraester |
| DE3902079A1 (de) * | 1988-04-15 | 1989-10-26 | Bayer Ag | I.m. injektionsformen von gyrase-inhibitoren |
| AU618823B2 (en) * | 1988-07-20 | 1992-01-09 | Sankyo Company Limited | 4-oxoquinoline-3-carboxylic acid derivatives, their preparation and their use |
| CA1336090C (en) * | 1988-08-31 | 1995-06-27 | Isao Hayakawa | Spiro-substituted cyclic amines of quinolone derivatives |
| CA2012681A1 (en) * | 1989-03-31 | 1990-09-30 | Masayasu Okuhira | Quinolone derivatives, preparation processes thereof, and antibacterial agents containing the same |
| DE3918544A1 (de) * | 1989-06-07 | 1990-12-13 | Bayer Ag | Verfahren zur herstellung von 7-(3-amino- sowie 3-amino-methyl-1-pyrrolidinyl)-3-chinolon- carbonsaeuren sowie -naphthyridoncarbonsaeuren |
| DE4019023A1 (de) * | 1990-06-14 | 1991-12-19 | Bayer Ag | Verfahren zur herstellung von chinolincarbonsaeuren |
| US5157128A (en) * | 1990-11-30 | 1992-10-20 | Warner-Lambert Company | Certain optically active substituted α,α-dialkyl-pyrrolidine-3-methamines useful as intermediates |
| DE69131428T2 (de) * | 1990-11-30 | 2000-01-05 | Warner Lambert Co | Individuelle stereoisomere von 7-[3-(aminoalkyl)-1-pyrrolidinyl]-quinolone und naphthyridone als antibakterielle wirkstoffe |
| US5364861A (en) * | 1990-11-30 | 1994-11-15 | Warner-Lambert Company | Optical isomers of 7-[3-(1,1-dialkylmethyl-1-amino-1-pyrrolidinyl]-quinolones and naphthyridones as antibacterial agents |
| US5258528A (en) * | 1990-11-30 | 1993-11-02 | Warner-Lambert Company | Individual stereoisomers of pyrrolidine methanamines substituted on the ring nitrogen by a 1-phenylethyl group |
| DE4301245A1 (de) * | 1993-01-19 | 1994-07-21 | Bayer Ag | Fluor-trifluormethylbenzoesäure-Derivate |
| DE4342186A1 (de) * | 1993-12-10 | 1995-06-14 | Bayer Ag | Eintopfverfahren zur Herstellung von 3-Chinoloncarbonsäurederivaten |
| CZ12097A3 (en) * | 1994-07-18 | 1997-09-17 | Ube Industries | Trifluoromethylquinolinecarboxylic acid derivatives and pharmaceutical composition containing thereof |
| ID16655A (id) * | 1996-04-24 | 1997-10-30 | Daiichi Seiyaku Co | Turunan-turunan sikloalkilaminometilpirolidina |
| DE69716962T2 (de) * | 1996-08-19 | 2003-07-03 | Ube Industries | Verfahren zur herstellung von substituierten trifluorobenzoesäurederivaten und deren ester |
| SK286420B6 (sk) * | 1997-09-15 | 2008-09-05 | The Procter & Gamble Company | Zlúčenina so štruktúrou chinolónu, farmaceutický prostriedok s jej obsahom a jej použitie |
| US6387928B1 (en) | 1997-09-15 | 2002-05-14 | The Procter & Gamble Co. | Antimicrobial quinolones, their compositions and uses |
| KR100364226B1 (ko) * | 1998-03-18 | 2003-01-24 | 주식회사 엘지생명과학 | 7-할로-1-시클로프로필-6-플루오로-4-옥소-1,4-디히드로-[1.8]나프티리딘-3-카복실레이트의 제조방법 |
| SE0003795D0 (sv) * | 2000-10-20 | 2000-10-20 | Astrazeneca Ab | Pharmaceutically useful compounds |
| KR20020072602A (ko) * | 2001-03-12 | 2002-09-18 | (주)인산 | 기능미의 제조방법 |
| JP3729339B2 (ja) * | 2001-10-03 | 2005-12-21 | 株式会社サタケ | 発芽胚芽米の製造方法 |
| KR100448505B1 (ko) * | 2001-11-28 | 2004-09-13 | 삼서농업협동조합 | 발아현미 제조방법 |
| US8022247B2 (en) * | 2005-04-06 | 2011-09-20 | Chugai Seiyaku Kabushiki Kaisha | Process for production of 2,3,4-trifluoro-5-(iodo or bromo)-benzoic acid |
| CA2647454A1 (en) * | 2006-03-28 | 2007-10-04 | The Procter & Gamble Company | A coupling process for preparing quinolone intermediates |
| BRPI0709772B8 (pt) * | 2006-03-28 | 2021-05-25 | The Protecter & Gamble Company | sais de malato e polimorfos do ácido (3s,5s)-7-[3-amino-5-metil-piperidinil]-1-ciclopropil-1,4-diidro-8-metóxi-4-oxo-3-quinolinocarboxílico |
| US7528264B2 (en) * | 2006-03-28 | 2009-05-05 | The Procter & Gamble Company | Hydride reduction process for preparing quinolone intermediates |
| US8809552B2 (en) * | 2011-11-01 | 2014-08-19 | Hoffmann-La Roche Inc. | Azetidine compounds, compositions and methods of use |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB830832A (en) * | 1957-02-15 | 1960-03-23 | Ici Ltd | New quinolones and therapeutic compositions containing them |
| US4665079A (en) * | 1984-02-17 | 1987-05-12 | Warner-Lambert Company | Antibacterial agents |
| US4571396A (en) * | 1984-04-16 | 1986-02-18 | Warner-Lambert Company | Antibacterial agents |
| IE58742B1 (en) * | 1984-07-20 | 1993-11-05 | Warner Lambert Co | Substituted-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7h-pyrido[1,2,3-de] [1,4]benzoxauine-6-carboxylic acids; sibstituted-5-amino-6-6fluoro-4-oxo.1,4-dihydroquinoline-3 carboxylic acids; substituted-5-amino-6-fluoro-1,4-dihydro-4-oxo-1.8-naphthyridine-3-carboxylic acids; derivatives thereof; pharmaceutical compositions comprising the compounds; and processes for producing the compounds |
| DE3576686D1 (de) * | 1984-08-15 | 1990-04-26 | Boots Co Ltd | Chinolinone, verfahren zu ihrer herstellung und die sie enthaltenden pharmazeutischen praeparate. |
| DE3525108A1 (de) * | 1985-06-07 | 1986-12-11 | Bayer Ag, 5090 Leverkusen | Antibakteriell wirksame chinoloncarbonsaeureester |
| AU594983B2 (en) * | 1985-10-29 | 1990-03-22 | Dainippon Pharmaceutical Co. Ltd. | Novel quinoline derivatives and processes for preparation thereof |
| JPS62108878A (ja) * | 1985-11-05 | 1987-05-20 | Kyorin Pharmaceut Co Ltd | キノロンカルボン酸誘導体およびその製造方法 |
| US4977154A (en) * | 1985-12-12 | 1990-12-11 | Warner-Lambert Company | 5-amino and 5-hydroxy-6-fluoroquinolones as antibacterial agents |
| JPH089597B2 (ja) * | 1986-01-21 | 1996-01-31 | 杏林製薬株式会社 | 選択毒性に優れた８‐アルコキシキノロンカルボン酸およびその塩並びにその製造方法 |
| DE3705621C2 (de) * | 1986-02-25 | 1997-01-09 | Otsuka Pharma Co Ltd | Heterocyclisch substituierte Chinoloncarbonsäurederivate |
| US4851418A (en) * | 1987-08-21 | 1989-07-25 | Warner-Lambert Company | Naphthyridine antibacterial agents containing an α-amino acid in the side chain of the 7-substituent |
-
1987
- 1987-08-07 US US07/083,532 patent/US4780468A/en not_active Expired - Fee Related
-
1988
- 1988-07-27 AU AU20060/88A patent/AU616422B2/en not_active Expired - Fee Related
- 1988-07-28 ZA ZA885546A patent/ZA885546B/xx unknown
- 1988-07-29 KR KR1019880009582A patent/KR890003735A/ko not_active Application Discontinuation
- 1988-07-29 NZ NZ225626A patent/NZ225626A/en unknown
- 1988-08-03 FI FI883628A patent/FI883628A/fi not_active Application Discontinuation
- 1988-08-04 NO NO88883475A patent/NO883475L/no unknown
- 1988-08-05 JP JP63194743A patent/JPS6466180A/ja active Pending
- 1988-08-05 PH PH37363A patent/PH24784A/en unknown
- 1988-08-05 DK DK439688A patent/DK439688A/da not_active Application Discontinuation
- 1988-08-05 EP EP88112822A patent/EP0302525A3/en not_active Withdrawn
- 1988-08-05 PT PT88203A patent/PT88203A/pt not_active Application Discontinuation
-
1991
- 1991-09-09 AU AU83743/91A patent/AU8374391A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP0302525A3 (en) | 1990-08-22 |
| DK439688A (da) | 1989-02-08 |
| NO883475D0 (no) | 1988-08-04 |
| PH24784A (en) | 1990-10-30 |
| EP0302525A2 (en) | 1989-02-08 |
| NZ225626A (en) | 1991-03-26 |
| US4780468A (en) | 1988-10-25 |
| FI883628A0 (fi) | 1988-08-03 |
| PT88203A (pt) | 1989-06-30 |
| NO883475L (no) | 1989-02-08 |
| AU2006088A (en) | 1989-02-09 |
| AU8374391A (en) | 1991-11-14 |
| JPS6466180A (en) | 1989-03-13 |
| AU616422B2 (en) | 1991-10-31 |
| KR890003735A (ko) | 1989-04-17 |
| FI883628A (fi) | 1989-02-08 |
| DK439688D0 (da) | 1988-08-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PH24784A (en) | 8-trifluoromethyl quinolones as antibacterial agents | |
| KR100211005B1 (en) | Antimicrobial carbapenem quinolones | |
| ZA85854B (en) | Antibacterial agents | |
| PH29981A (en) | Antimicrobial dithiocarbamoyl quinolones | |
| IE872696L (en) | 1-tertiary-alkyl-substituted naphthyridine-and¹quinoline-carboxylic acid antibacterial agents | |
| PH24824A (en) | Antibacterial agents | |
| GB8626240D0 (en) | Antimicrobial agents | |
| GR860998B (en) | Antibacterial agents | |
| GB8705305D0 (en) | Antimicrobial agents | |
| PH21230A (en) | Novel napthyridine and quinoline antibacterial agents | |
| ZA877471B (en) | 1-tertiary-alkyl-substituted naphthyridine-and quinoline-carboxylic acid antibacterial agents | |
| AU4743890A (en) | Antibacterial quinolone compounds | |
| JPS6450884A (en) | Antibacterial | |
| GB8612137D0 (en) | Quinolone compounds | |
| EP0430485A3 (en) | Quinoline compound | |
| ZA912717B (en) | Quinolinecarboxylic acid antibacterial agents | |
| ZA85853B (en) | Antibacterial agents | |
| ZA852369B (en) | Quinoline antibacterial compounds | |
| GB8506868D0 (en) | Antibacterial compound | |
| IE893431L (en) | Novel antimicrobial lactam quinolones | |
| IE863141L (en) | Quinoline-3-carboxylic acid antibacterial agents | |
| GB8702508D0 (en) | Quinoline compound | |
| IE882208L (en) | 8-trifluoromethyl quinolones | |
| ZA885895B (en) | Antibacterial agents | |
| PH24864A (en) | Quinoline thiothers |