ZA873461B - Hybrid polypeptides comprising somatocrinine and alpha-antitrypsin,method for their production from bacterial clones and use thereof for the production of somatocrinine - Google Patents

Hybrid polypeptides comprising somatocrinine and alpha-antitrypsin,method for their production from bacterial clones and use thereof for the production of somatocrinine

Info

Publication number
ZA873461B
ZA873461B ZA873461A ZA873461A ZA873461B ZA 873461 B ZA873461 B ZA 873461B ZA 873461 A ZA873461 A ZA 873461A ZA 873461 A ZA873461 A ZA 873461A ZA 873461 B ZA873461 B ZA 873461B
Authority
ZA
South Africa
Prior art keywords
somatocrinine
production
antitrypsin
alpha
hybrid polypeptides
Prior art date
Application number
ZA873461A
Other languages
English (en)
Inventor
Alex Joseph Bollen
Joseph Bollen Alex
Paul Jacobs
Jacobs Paul
Original Assignee
Smith Kline Rit
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith Kline Rit filed Critical Smith Kline Rit
Publication of ZA873461B publication Critical patent/ZA873461B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C07K14/8125—Alpha-1-antitrypsin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/848—Escherichia
    • Y10S435/849—Escherichia coli

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
ZA873461A 1986-05-15 1987-05-14 Hybrid polypeptides comprising somatocrinine and alpha-antitrypsin,method for their production from bacterial clones and use thereof for the production of somatocrinine ZA873461B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/863,281 US4828988A (en) 1986-05-15 1986-05-15 Hybrid polypeptides comprising somatocrinine and alpha1 -antitrypsin, method for their production from bacterial clones and use thereof for the production of somatocrinine

Publications (1)

Publication Number Publication Date
ZA873461B true ZA873461B (en) 1988-03-30

Family

ID=25340766

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA873461A ZA873461B (en) 1986-05-15 1987-05-14 Hybrid polypeptides comprising somatocrinine and alpha-antitrypsin,method for their production from bacterial clones and use thereof for the production of somatocrinine

Country Status (7)

Country Link
US (1) US4828988A (de)
EP (1) EP0252894A3 (de)
JP (1) JPS62278986A (de)
AU (1) AU7268287A (de)
DK (1) DK248087A (de)
PT (1) PT84879B (de)
ZA (1) ZA873461B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ218148A (en) * 1985-11-08 1989-06-28 Smithkline Beckman Corp E.coli expression vector coding for alpha-1-antitrypsin
SE8800981A (sv) * 1988-03-17 1988-10-14 Lars Abrahamsen A recombinant fusion protein, its use and a recombinant vector
US5164304A (en) * 1989-05-04 1992-11-17 Sri International Method and vectors for stabilizing hirudin and human laminin b1 expression
NZ236819A (en) * 1990-02-03 1993-07-27 Max Planck Gesellschaft Enzymatic cleavage of fusion proteins; fusion proteins; recombinant dna and pharmaceutical compositions
KR920003787B1 (ko) * 1990-03-05 1992-05-14 한국과학기술 연구원 신규 플라스미드 제조 및 그를 함유한 균주를 배양하여 아이 지 에프-1(igf-1)을 생산하는 방법
US5292646A (en) * 1991-02-06 1994-03-08 Genetics Institute, Inc. Peptide and protein fusions to thioredoxin and thioredoxin-like molecules
US5270181A (en) * 1991-02-06 1993-12-14 Genetics Institute, Inc. Peptide and protein fusions to thioredoxin and thioredoxin-like molecules
DE69432787D1 (de) * 1993-01-15 2003-07-10 Inst Genetics Llc Klonierung von Enterokinase und Verfahren zu deren Verwendung
US6746859B1 (en) 1993-01-15 2004-06-08 Genetics Institute, Llc Cloning of enterokinase and method of use
US5512459A (en) * 1993-07-20 1996-04-30 Bionebraska, Inc. Enzymatic method for modification or recombinant polypeptides
CA2475388A1 (en) * 2002-02-14 2003-08-21 William J. Rutter Chimeric molecules for cleavage in a treated host
FR2852247A1 (fr) * 2003-03-11 2004-09-17 Centre Nat Rech Scient Utilisation de ligands peptidiques de recepteurs de la membrane plasmique et de leurs analogues pour moduler l'activite des mitochondries

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4546082A (en) * 1982-06-17 1985-10-08 Regents Of The Univ. Of California E. coli/Saccharomyces cerevisiae plasmid cloning vector containing the alpha-factor gene for secretion and processing of hybrid proteins
EP0114777B1 (de) * 1983-01-21 1990-08-01 Transgene S.A. Expressionsvektoren und deren Verwendung zur Herstellung eines Proteins mit menschlicher alpha-Antitrypsin-Aktivität
JPS59227899A (ja) * 1983-05-25 1984-12-21 チロン・コ−ポレイシヨン 成長ホルモン放出因子の製造方法
ZA844380B (en) * 1983-07-05 1985-01-30 Salk Inst For Biological Studi Dna encoding a grf precursor
JPS60186290A (ja) * 1983-08-10 1985-09-21 チモ−ジエネテイツクス　インコ−ポレ−テツド アルフア−１−アンチトリプシンを細菌に表現させる方法
US4617149A (en) * 1983-09-21 1986-10-14 Eli Lilly And Company Growth hormone release factor analogs
GB8334498D0 (en) * 1983-12-24 1984-02-01 Beecham Group Plc Compounds
BE901119A (fr) * 1984-11-23 1985-03-15 Wallone Region Procede de preparation de plasmides vecteurs capables de transformer un hote bacterien escherichia coli et d'y promouvoir et controler l'expression d'un adn heterologue.
IT1234977B (it) * 1985-03-22 1992-06-09 Serono Ist Farm Espressione in e. coli polipeptidi ibridi contenenti la sequenza del fattore di rilascio dell'ormone della crescita
US4689318A (en) * 1985-08-29 1987-08-25 The Salk Institute For Biological Studies GRF analogs

Also Published As

Publication number Publication date
PT84879A (en) 1987-06-01
EP0252894A3 (de) 1989-08-09
AU7268287A (en) 1987-11-19
DK248087A (da) 1987-11-16
EP0252894A2 (de) 1988-01-13
PT84879B (en) 1989-07-10
DK248087D0 (da) 1987-05-14
JPS62278986A (ja) 1987-12-03
US4828988A (en) 1989-05-09

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