ZA869616B - "3-(2-aminoethyl)indole and indoline derivatives,processes for their preparation and pharmaceutical compositions containing them - Google Patents
"3-(2-aminoethyl)indole and indoline derivatives,processes for their preparation and pharmaceutical compositions containing themInfo
- Publication number
- ZA869616B ZA869616B ZA869616A ZA869616A ZA869616B ZA 869616 B ZA869616 B ZA 869616B ZA 869616 A ZA869616 A ZA 869616A ZA 869616 A ZA869616 A ZA 869616A ZA 869616 B ZA869616 B ZA 869616B
- Authority
- ZA
- South Africa
- Prior art keywords
- aminoethyl
- indole
- processes
- preparation
- pharmaceutical compositions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB858531612A GB8531612D0 (en) | 1985-12-23 | 1985-12-23 | Compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA869616B true ZA869616B (en) | 1988-09-28 |
Family
ID=10590170
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA869616A ZA869616B (en) | 1985-12-23 | 1986-12-22 | "3-(2-aminoethyl)indole and indoline derivatives,processes for their preparation and pharmaceutical compositions containing them |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4980368A (xx) |
| EP (1) | EP0233413B1 (xx) |
| JP (1) | JPS62181252A (xx) |
| AU (1) | AU597017B2 (xx) |
| DE (1) | DE3688397T2 (xx) |
| DK (1) | DK625286A (xx) |
| ES (1) | ES2055688T3 (xx) |
| GB (1) | GB8531612D0 (xx) |
| IE (1) | IE60126B1 (xx) |
| NZ (1) | NZ218754A (xx) |
| PT (1) | PT84014B (xx) |
| ZA (1) | ZA869616B (xx) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ238424A (en) * | 1990-06-07 | 1993-12-23 | Wellcome Found | 3,5-substituted indole derivatives; medicaments and preparatory processes. |
| US5145845A (en) * | 1991-05-14 | 1992-09-08 | Warner-Lambert Co. | Substituted 2-carboxylindoles having pharmaceutical activity |
| US5233050A (en) * | 1992-02-07 | 1993-08-03 | Merck & Co., Inc. | Antimigraine alkyl indole |
| ITRM20010356A1 (it) * | 2001-06-21 | 2002-12-23 | Sigma Tau Ind Farmaceuti | "5-alogeno derivati della triptamina utili come ligandi del recettore5-ht6 e/o 5-ht7 della serotonina. |
| KR101493530B1 (ko) * | 2006-06-12 | 2015-02-13 | 노파르티스 아게 | Ｎ-히드록시-3-［4-［［［2-(2-메틸-1ｈ-인돌-3-일)에틸］아미노］메틸］페닐］-2ｅ-2-프로펜아미드 및 이의 출발 물질의 제조 방법 |
| US10093640B2 (en) | 2012-09-21 | 2018-10-09 | Vanderbilt University | Substituted benzofuran, benzothiophene and indole MCL-1 inhibitors |
| WO2015031608A1 (en) | 2013-08-28 | 2015-03-05 | Vanderbilt University | Substituted indole mcl-1 inhibitors |
| AU2015235944B2 (en) | 2014-03-27 | 2020-06-25 | Vanderbilt University | Substituted indole Mcl-1 inhibitors |
| WO2017152076A1 (en) | 2016-03-04 | 2017-09-08 | Vanderbilt University | Substituted indole mcl-1 inhibitors |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA613852A (en) * | 1961-01-31 | L. Clark Robert | Substituted tryptamines | |
| US3042685A (en) * | 1962-07-03 | Process of making g-fluoro tryptamine | ||
| GB781390A (en) * | 1954-04-28 | 1957-08-21 | Upjohn Co | Preparation of 3-(2-aminoethyl)-indoles |
| GB841524A (en) * | 1955-11-18 | 1960-07-20 | May & Baker Ltd | Improvements in or relating to indole derivatives |
| US2890223A (en) * | 1956-03-22 | 1959-06-09 | Research Corp | 1-benzyl, 2-methyl, 5-methoxy tryptamine |
| GB859223A (en) * | 1957-03-27 | 1961-01-18 | Merck & Co Inc | Tryptamine compounds |
| GB888426A (en) * | 1957-08-02 | 1962-01-31 | Lab Francais Chimiotherapie | Tryptamine-2-carboxylic acid derivatives and their preparation |
| US2908691A (en) * | 1958-07-14 | 1959-10-13 | Searle & Co | Hydroxyphenalkylaminoalkylindoles and ethers corresponding thereto |
| US3217029A (en) * | 1961-06-27 | 1965-11-09 | Warner Lambert Pharmaceutical | Method of preparing substituted indole derivatives |
| US3296072A (en) * | 1962-06-11 | 1967-01-03 | Upjohn Co | Method of treating mental depression |
| GB1189064A (en) * | 1967-05-01 | 1970-04-22 | Sterling Drug Inc | Indole Derivatives |
| US3686213A (en) * | 1970-08-28 | 1972-08-22 | American Cyanamid Co | Substituted aminoethyl indoles |
| FR2181559A1 (en) * | 1972-04-28 | 1973-12-07 | Aec Chimie Organique Bio | N-Phenylalkyl-N-3-indolylalkyl-alkylamines - with sedative, neuroleptic, analgesic, hypotensive, antiserotonin, adrenolytic activity |
| GB1374414A (en) * | 1972-06-12 | 1974-11-20 | Sterling Drug Inc | 1-acyl-3-amino-alkyl-indoles and their preparation |
| US3915990A (en) * | 1973-03-13 | 1975-10-28 | Nelson Res & Dev | Tryptamines |
| US3910953A (en) * | 1973-08-16 | 1975-10-07 | Richter Gedeon Vegyeszet | Process for the preparation of tryptamine or its derivatives |
-
1985
- 1985-12-23 GB GB858531612A patent/GB8531612D0/en active Pending
-
1986
- 1986-12-22 ES ES86310010T patent/ES2055688T3/es not_active Expired - Lifetime
- 1986-12-22 DK DK625286A patent/DK625286A/da not_active Application Discontinuation
- 1986-12-22 AU AU66826/86A patent/AU597017B2/en not_active Ceased
- 1986-12-22 EP EP86310010A patent/EP0233413B1/en not_active Expired - Lifetime
- 1986-12-22 NZ NZ218754A patent/NZ218754A/xx unknown
- 1986-12-22 IE IE337486A patent/IE60126B1/en not_active IP Right Cessation
- 1986-12-22 DE DE8686310010T patent/DE3688397T2/de not_active Expired - Lifetime
- 1986-12-22 ZA ZA869616A patent/ZA869616B/xx unknown
- 1986-12-23 PT PT84014A patent/PT84014B/pt unknown
- 1986-12-23 US US06/946,387 patent/US4980368A/en not_active Expired - Lifetime
- 1986-12-23 JP JP61307566A patent/JPS62181252A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DE3688397T2 (de) | 1993-09-09 |
| AU597017B2 (en) | 1990-05-24 |
| PT84014A (en) | 1987-01-01 |
| DK625286A (da) | 1987-06-24 |
| JPS62181252A (ja) | 1987-08-08 |
| NZ218754A (en) | 1991-05-28 |
| DE3688397D1 (de) | 1993-06-09 |
| DK625286D0 (da) | 1986-12-22 |
| IE863374L (en) | 1987-06-23 |
| PT84014B (pt) | 1989-05-31 |
| ES2055688T3 (es) | 1994-09-01 |
| IE60126B1 (en) | 1994-06-01 |
| US4980368A (en) | 1990-12-25 |
| AU6682686A (en) | 1987-06-25 |
| EP0233413A2 (en) | 1987-08-26 |
| GB8531612D0 (en) | 1986-02-05 |
| EP0233413A3 (en) | 1989-04-26 |
| EP0233413B1 (en) | 1993-05-05 |
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