DK625286D0 - Hidtil ukendte forbindelser - Google Patents

Hidtil ukendte forbindelser

Info

Publication number
DK625286D0
DK625286D0 DK625286A DK625286A DK625286D0 DK 625286 D0 DK625286 D0 DK 625286D0 DK 625286 A DK625286 A DK 625286A DK 625286 A DK625286 A DK 625286A DK 625286 D0 DK625286 D0 DK 625286D0
Authority
DK
Denmark
Prior art keywords
unknown relationships
unknown
relationships
Prior art date
Application number
DK625286A
Other languages
English (en)
Other versions
DK625286A (da
Inventor
Dietrich Thielke
Dagmar Hoeltje
Original Assignee
Beecham Wuelfing Gmbh & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Wuelfing Gmbh & Co Kg filed Critical Beecham Wuelfing Gmbh & Co Kg
Publication of DK625286D0 publication Critical patent/DK625286D0/da
Publication of DK625286A publication Critical patent/DK625286A/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/30Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16Tryptamines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK625286A 1985-12-23 1986-12-22 Indolderivater DK625286A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB858531612A GB8531612D0 (en) 1985-12-23 1985-12-23 Compounds

Publications (2)

Publication Number Publication Date
DK625286D0 true DK625286D0 (da) 1986-12-22
DK625286A DK625286A (da) 1987-06-24

Family

ID=10590170

Family Applications (1)

Application Number Title Priority Date Filing Date
DK625286A DK625286A (da) 1985-12-23 1986-12-22 Indolderivater

Country Status (12)

Country Link
US (1) US4980368A (da)
EP (1) EP0233413B1 (da)
JP (1) JPS62181252A (da)
AU (1) AU597017B2 (da)
DE (1) DE3688397T2 (da)
DK (1) DK625286A (da)
ES (1) ES2055688T3 (da)
GB (1) GB8531612D0 (da)
IE (1) IE60126B1 (da)
NZ (1) NZ218754A (da)
PT (1) PT84014B (da)
ZA (1) ZA869616B (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL114690A (en) * 1990-06-07 1997-02-18 Wellcome Found Antimigraine oxazolidinone substituted indole derivatives
US5145845A (en) * 1991-05-14 1992-09-08 Warner-Lambert Co. Substituted 2-carboxylindoles having pharmaceutical activity
US5233050A (en) * 1992-02-07 1993-08-03 Merck & Co., Inc. Antimigraine alkyl indole
ITRM20010356A1 (it) * 2001-06-21 2002-12-23 Sigma Tau Ind Farmaceuti "5-alogeno derivati della triptamina utili come ligandi del recettore5-ht6 e/o 5-ht7 della serotonina.
RU2448090C2 (ru) * 2006-06-12 2012-04-20 Новартис Аг Способ получения n-гидрокси-3-[4-[[[2-(2-метил-1н-индол-3-ил)этил]амино]метил]фенил]-2е-2-пропенамида и исходных материалов для него
US10093640B2 (en) 2012-09-21 2018-10-09 Vanderbilt University Substituted benzofuran, benzothiophene and indole MCL-1 inhibitors
US10005728B2 (en) 2013-08-28 2018-06-26 Vanderbilt University Substituted indole Mcl-1 inhibitors
CA2943815C (en) 2014-03-27 2023-04-04 Vanderbilt University Substituted indole mcl-1 inhibitors
BR112018067775B1 (pt) 2016-03-04 2024-02-15 Vanderbilt University Compostos inibidores de mcl-1 indol substituídos, composição farmacêutica compreendendo ditos compostos e usos terapêuticos dos mesmos

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3042685A (en) * 1962-07-03 Process of making g-fluoro tryptamine
CA613852A (en) * 1961-01-31 L. Clark Robert Substituted tryptamines
GB781390A (en) * 1954-04-28 1957-08-21 Upjohn Co Preparation of 3-(2-aminoethyl)-indoles
GB841524A (en) * 1955-11-18 1960-07-20 May & Baker Ltd Improvements in or relating to indole derivatives
US2890223A (en) * 1956-03-22 1959-06-09 Research Corp 1-benzyl, 2-methyl, 5-methoxy tryptamine
GB859223A (en) * 1957-03-27 1961-01-18 Merck & Co Inc Tryptamine compounds
GB888426A (en) * 1957-08-02 1962-01-31 Lab Francais Chimiotherapie Tryptamine-2-carboxylic acid derivatives and their preparation
US2908691A (en) * 1958-07-14 1959-10-13 Searle & Co Hydroxyphenalkylaminoalkylindoles and ethers corresponding thereto
US3217029A (en) * 1961-06-27 1965-11-09 Warner Lambert Pharmaceutical Method of preparing substituted indole derivatives
US3296072A (en) * 1962-06-11 1967-01-03 Upjohn Co Method of treating mental depression
GB1189064A (en) * 1967-05-01 1970-04-22 Sterling Drug Inc Indole Derivatives
US3686213A (en) * 1970-08-28 1972-08-22 American Cyanamid Co Substituted aminoethyl indoles
FR2181559A1 (en) * 1972-04-28 1973-12-07 Aec Chimie Organique Bio N-Phenylalkyl-N-3-indolylalkyl-alkylamines - with sedative, neuroleptic, analgesic, hypotensive, antiserotonin, adrenolytic activity
GB1374414A (en) * 1972-06-12 1974-11-20 Sterling Drug Inc 1-acyl-3-amino-alkyl-indoles and their preparation
US3915990A (en) * 1973-03-13 1975-10-28 Nelson Res & Dev Tryptamines
US3910953A (en) * 1973-08-16 1975-10-07 Richter Gedeon Vegyeszet Process for the preparation of tryptamine or its derivatives

Also Published As

Publication number Publication date
IE60126B1 (en) 1994-06-01
EP0233413A3 (en) 1989-04-26
JPS62181252A (ja) 1987-08-08
AU6682686A (en) 1987-06-25
IE863374L (en) 1987-06-23
ZA869616B (en) 1988-09-28
DE3688397T2 (de) 1993-09-09
EP0233413B1 (en) 1993-05-05
PT84014B (pt) 1989-05-31
NZ218754A (en) 1991-05-28
DE3688397D1 (de) 1993-06-09
PT84014A (en) 1987-01-01
AU597017B2 (en) 1990-05-24
GB8531612D0 (en) 1986-02-05
ES2055688T3 (es) 1994-09-01
EP0233413A2 (en) 1987-08-26
US4980368A (en) 1990-12-25
DK625286A (da) 1987-06-24

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Legal Events

Date Code Title Description
AHS Application shelved for other reasons than non-payment