ZA868065B - Antihypertensive thieno-isoxazoles and-pyrazoles,a process and intermediates for their preparation and their use as medicaments - Google Patents
Antihypertensive thieno-isoxazoles and-pyrazoles,a process and intermediates for their preparation and their use as medicamentsInfo
- Publication number
- ZA868065B ZA868065B ZA868065A ZA868065A ZA868065B ZA 868065 B ZA868065 B ZA 868065B ZA 868065 A ZA868065 A ZA 868065A ZA 868065 A ZA868065 A ZA 868065A ZA 868065 B ZA868065 B ZA 868065B
- Authority
- ZA
- South Africa
- Prior art keywords
- isoxazoles
- thieno
- pyrazoles
- antihypertensive
- medicaments
- Prior art date
Links
- 230000003276 anti-hypertensive effect Effects 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/791,019 US4728651A (en) | 1985-10-24 | 1985-10-24 | Antihypertensive thieno-isoxazoles and -pyrazoles |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA868065B true ZA868065B (en) | 1987-06-24 |
Family
ID=25152414
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA868065A ZA868065B (en) | 1985-10-24 | 1986-10-23 | Antihypertensive thieno-isoxazoles and-pyrazoles,a process and intermediates for their preparation and their use as medicaments |
Country Status (10)
Country | Link |
---|---|
US (1) | US4728651A (ja) |
EP (1) | EP0221414A1 (ja) |
JP (1) | JPS62103086A (ja) |
KR (1) | KR870004037A (ja) |
AU (1) | AU6433786A (ja) |
DK (1) | DK507986A (ja) |
HU (1) | HU198058B (ja) |
IL (1) | IL80394A0 (ja) |
PT (1) | PT83606B (ja) |
ZA (1) | ZA868065B (ja) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9808663D0 (en) * | 1998-04-23 | 1998-06-24 | Merck Sharp & Dohme | Therapeutic agents |
CZ2002897A3 (cs) * | 1999-09-14 | 2002-07-17 | Aventis Pharmaceuticals, Inc. | Thienoisoxazolyl-, thienopyrazolyl-fenoxypropylderiváty a jejich pouľití jako antagonistů D4 |
US7125903B1 (en) * | 1999-09-14 | 2006-10-24 | Aventis Pharmaceuticals Inc. | Thienoisoxazolyl-and thienylpyrrazolyl-phenoxy substituted propyl derivatives useful as D4 antagonists |
US7253165B2 (en) * | 1999-09-14 | 2007-08-07 | Aventis Pharmaceuticals Inc. | Benzisoxazolyl-, pyridoisoxazolyl-and benzthienyl-phenoxy derivatives useful as D4 antagonists |
US7091199B1 (en) | 1999-09-14 | 2006-08-15 | Aventis Pharmaceuticals Inc. | Thienoisoxazole phenoxy unsubstituted ethyl and propyl derivatives useful as d4 antagonists |
ATE254620T1 (de) * | 1999-09-14 | 2003-12-15 | Aventis Pharma Inc | Unsubstituierte ethyl- und propylderivate von phenoxythienoisoxazolen als d4 antagonisten |
ATE329901T1 (de) | 2000-11-10 | 2006-07-15 | Lilly Co Eli | 3-substituierte oxindolderivate als beta-3- agonisten |
ATE325119T1 (de) | 2001-08-14 | 2006-06-15 | Lilly Co Eli | 3-substituierte oxindol-beta-3-agonisten |
ES2272749T3 (es) * | 2001-08-14 | 2007-05-01 | Eli Lilly And Company | Derivados de indol como agonistas beta-3 adrenergicos para el tratamiento de diabetes tipo 2. |
JP2005514366A (ja) | 2001-11-20 | 2005-05-19 | イーライ・リリー・アンド・カンパニー | 3−置換オキシインドールβ3アゴニスト |
EP1448561B1 (en) | 2001-11-20 | 2008-02-20 | Eli Lilly And Company | Beta 3 adrenergic agonists |
AU2002357084A1 (en) | 2002-01-11 | 2003-07-30 | Eli Lilly And Company | 2-oxo-benzimidazolyl substituted ethanolamine derivatives and their use as beta3 agonists |
KR20040020457A (ko) * | 2002-08-30 | 2004-03-09 | 주식회사 대웅 | 3-{2-[4-(6-플루오로벤조[d]이속사졸-3-일)피페리디노]에틸}-2-메틸-6,7,8,9-테트라하이드로-4H-피리도[1,2-a]피리미딘-4-온 또는 그 산부가염의 제조방법 |
BR112015022787A2 (pt) | 2013-03-15 | 2017-11-07 | Epizyme Inc | compostos, composições farmacêuticas, kit ou artigo farmacêutico embalado, e método de tratamento de um distúrbio mediado por carm1 |
CN113072562B (zh) * | 2021-04-06 | 2022-01-14 | 山东大学 | 一种GSK-3β抑制剂及其制备方法与应用 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3655661A (en) * | 1968-05-22 | 1972-04-11 | Frosst & Co Charles E | Benzothiadiazole compounds |
AU518487B2 (en) * | 1975-07-16 | 1981-10-01 | Boehringer Ingelheim International Gmbh | 5-aryl-thieno-(2,3-e)-4,1-oxazepin-2-ones |
US4245104A (en) * | 1978-12-01 | 1981-01-13 | Hoffmann-La Roche Inc. | Isoxazolines and isoxazolidines |
US4247704A (en) * | 1979-05-29 | 1981-01-27 | Hoffmann-La Roche Inc. | Hexahydro thieno imadazole intermediates for the synthesis of biotin |
DE2926517A1 (de) * | 1979-06-30 | 1981-01-15 | Beiersdorf Ag | Substituierte 3-aryl-pyrazole und 5-aryl-isoxazole und verfahren zu ihrer herstellung |
CA1156661A (en) * | 1980-02-25 | 1983-11-08 | Hoffmann-La Roche Limited | Phenoxy-aminopropanol derivatives |
DE3101456A1 (de) * | 1981-01-19 | 1982-09-02 | Basf Ag, 6700 Ludwigshafen | Phenylpiperazinyl-propanole von hetarylphenolen, ihre herstellung und diese enthaltende therapeutische mittel |
JPS5846079A (ja) * | 1981-09-12 | 1983-03-17 | Santen Pharmaceut Co Ltd | ベンゾチアゾリン環を有するエ−テル類 |
-
1985
- 1985-10-24 US US06/791,019 patent/US4728651A/en not_active Expired - Lifetime
-
1986
- 1986-10-16 EP EP86114314A patent/EP0221414A1/en not_active Withdrawn
- 1986-10-22 IL IL80394A patent/IL80394A0/xx unknown
- 1986-10-23 JP JP61250937A patent/JPS62103086A/ja active Pending
- 1986-10-23 PT PT83606A patent/PT83606B/pt unknown
- 1986-10-23 AU AU64337/86A patent/AU6433786A/en not_active Abandoned
- 1986-10-23 HU HU864456A patent/HU198058B/hu not_active IP Right Cessation
- 1986-10-23 DK DK507986A patent/DK507986A/da not_active Application Discontinuation
- 1986-10-23 ZA ZA868065A patent/ZA868065B/xx unknown
- 1986-10-23 KR KR1019860008875A patent/KR870004037A/ko not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
DK507986A (da) | 1987-04-25 |
JPS62103086A (ja) | 1987-05-13 |
PT83606B (en) | 1988-11-15 |
US4728651A (en) | 1988-03-01 |
HUT45061A (en) | 1988-05-30 |
DK507986D0 (da) | 1986-10-23 |
IL80394A0 (en) | 1987-01-30 |
HU198058B (en) | 1989-07-28 |
PT83606A (en) | 1986-11-01 |
AU6433786A (en) | 1987-04-30 |
KR870004037A (ko) | 1987-05-07 |
EP0221414A1 (en) | 1987-05-13 |
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