ZA86393B - Process for preparing glucagon or derivatives of fragments thereof in yeast - Google Patents

Process for preparing glucagon or derivatives of fragments thereof in yeast

Info

Publication number
ZA86393B
ZA86393B ZA86393A ZA86393A ZA86393B ZA 86393 B ZA86393 B ZA 86393B ZA 86393 A ZA86393 A ZA 86393A ZA 86393 A ZA86393 A ZA 86393A ZA 86393 B ZA86393 B ZA 86393B
Authority
ZA
South Africa
Prior art keywords
derivatives
yeast
fragments
glucagon
expression
Prior art date
Application number
ZA86393A
Other languages
English (en)
Inventor
Kjeld Norris
Lars Thim
Fanny Norris
Mogens Trier Hansen
Alister James Moody
Original Assignee
Novo Industri As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Industri As filed Critical Novo Industri As
Publication of ZA86393B publication Critical patent/ZA86393B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/605Glucagons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/39Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00Peptide or protein sequence
    • Y10S930/01Peptide or protein sequence
    • Y10S930/30Signal or leader sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Plant Pathology (AREA)
  • Emergency Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ZA86393A 1985-01-22 1986-01-20 Process for preparing glucagon or derivatives of fragments thereof in yeast ZA86393B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK27885A DK27885A (da) 1985-01-22 1985-01-22 Fremstilling af peptider

Publications (1)

Publication Number Publication Date
ZA86393B true ZA86393B (en) 1987-03-25

Family

ID=8091749

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA86393A ZA86393B (en) 1985-01-22 1986-01-20 Process for preparing glucagon or derivatives of fragments thereof in yeast

Country Status (17)

Country Link
US (1) US4826763A (de)
EP (1) EP0189998B1 (de)
JP (2) JPH0720435B2 (de)
AT (1) ATE48643T1 (de)
AU (1) AU587218B2 (de)
CA (1) CA1294232C (de)
DE (1) DE3667488D1 (de)
DK (1) DK27885A (de)
ES (1) ES8708250A1 (de)
FI (1) FI87800C (de)
GR (1) GR860149B (de)
IE (1) IE58726B1 (de)
MX (1) MX163776B (de)
NO (1) NO172185C (de)
NZ (1) NZ214883A (de)
PT (1) PT81872B (de)
ZA (1) ZA86393B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5151354A (en) * 1986-08-21 1992-09-29 Cornelius Hollenberg Fermentation processes using amylolytic enzyme producing microorganisms
DK175919B1 (da) * 1986-09-19 2005-06-27 Univ Washington Ekspression af biologisk aktiv faktor XIII
JPH01187499A (ja) * 1988-01-21 1989-07-26 Science & Tech Agency 原子炉解体用ロボット
ZA90533B (en) * 1989-02-01 1990-10-31 Shionogi & Co A method for the production of glucagon
US6172039B1 (en) 1990-04-16 2001-01-09 Apex Bioscience, Inc. Expression of recombinant hemoglobin and hemoglobin variants in yeast
US5234906A (en) * 1991-01-10 1993-08-10 Amylin Pharmaceuticals, Inc. Hyperglycemic compositions
US5408037A (en) * 1991-01-17 1995-04-18 Zymogenetics, Inc. Methods for detecting glucagon antagonists
US5510459A (en) * 1991-01-17 1996-04-23 Zymogenetics, Inc. Glucagon antagonists
JPH08500052A (ja) * 1992-07-06 1996-01-09 ベックマン インスツルメンツ インコーポレーテッド 多重ポート弁を使用する流体配送装置
DK144093D0 (de) * 1993-12-23 1993-12-23 Novo Nordisk As
US5652216A (en) * 1994-05-26 1997-07-29 Novo Nordisk A/S Pharmaceutical preparation
DE69819488T2 (de) * 1997-05-16 2004-08-26 1149336 Ontario Inc., Toronto Verwendung von glp-2 agonisten zur verbesserung der wirkung des oberen gastrointestinaltraktes
US7655618B2 (en) 2002-12-27 2010-02-02 Diobex, Inc. Compositions and methods for the prevention and control of insulin-induced hypoglycemia
WO2004060387A1 (en) * 2002-12-27 2004-07-22 Diobex, Inc. Compositions and methods for the prevention and control of insulin-induced hypoglycemia
CN102348715B (zh) 2009-02-03 2017-12-08 阿穆尼克斯运营公司 延伸重组多肽和包含该延伸重组多肽的组合物
NZ596778A (en) 2009-06-08 2013-11-29 Amunix Operating Inc Glucose-regulating polypeptides and methods of making and using same
WO2013130684A1 (en) 2012-02-27 2013-09-06 Amunix Operating Inc. Xten-folate conjugate compositions and methods of making same
CN112912390B (zh) 2018-10-09 2023-12-15 北京费森尤斯卡比医药有限公司 Glp-1类似物的制备方法
EP3753946A1 (de) 2019-06-18 2020-12-23 Fresenius Kabi iPSUM S.r.l. Verbessertes verfahren zur herstellung von hochreinem glucagon
US20220324936A1 (en) 2019-06-18 2022-10-13 Fresenius Kabi Ipsum S.R.L. Process for the manufacture of glucagon
EP4058466A1 (de) 2019-11-13 2022-09-21 Amunix Pharmaceuticals, Inc. Strichcodierte xten-polypeptide und zusammensetzungen davon sowie verfahren zu ihrer herstellung und verwendung

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4401759A (en) * 1980-05-01 1983-08-30 Harvey Rubin Detection and isolation of glucagon mRNA using a synthetic oligodeoxynucleotide
DK283180A (da) * 1980-07-01 1982-01-02 Novo Industri As Polypeptider og derivater deraf
US4546082A (en) * 1982-06-17 1985-10-08 Regents Of The Univ. Of California E. coli/Saccharomyces cerevisiae plasmid cloning vector containing the alpha-factor gene for secretion and processing of hybrid proteins

Also Published As

Publication number Publication date
ES8708250A1 (es) 1987-10-01
JPH06292594A (ja) 1994-10-21
CA1294232C (en) 1992-01-14
NO172185C (no) 1993-06-16
IE860162L (en) 1986-07-22
DE3667488D1 (de) 1990-01-18
FI87800B (fi) 1992-11-13
FI860251A (fi) 1986-07-23
AU587218B2 (en) 1989-08-10
DK27885D0 (da) 1985-01-22
NO172185B (no) 1993-03-08
MX163776B (es) 1992-06-22
JPH0746986B2 (ja) 1995-05-24
JPS61181398A (ja) 1986-08-14
JPH0720435B2 (ja) 1995-03-08
US4826763A (en) 1989-05-02
IE58726B1 (en) 1993-11-03
PT81872B (pt) 1988-05-27
PT81872A (en) 1986-02-01
NO860178L (no) 1986-07-23
GR860149B (en) 1986-05-21
EP0189998B1 (de) 1989-12-13
ATE48643T1 (de) 1989-12-15
FI860251A0 (fi) 1986-01-20
FI87800C (fi) 1993-02-25
DK27885A (da) 1986-07-23
AU5247286A (en) 1986-07-31
ES551042A0 (es) 1987-10-01
NZ214883A (en) 1988-04-29
EP0189998A1 (de) 1986-08-06

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