ZA846698B - Crystalline salts of l or(s)-3-(3,4-dihydroxyphenyl)-2-methylalanine esters and process - Google Patents

Crystalline salts of l or(s)-3-(3,4-dihydroxyphenyl)-2-methylalanine esters and process

Info

Publication number
ZA846698B
ZA846698B ZA846698A ZA846698A ZA846698B ZA 846698 B ZA846698 B ZA 846698B ZA 846698 A ZA846698 A ZA 846698A ZA 846698 A ZA846698 A ZA 846698A ZA 846698 B ZA846698 B ZA 846698B
Authority
ZA
South Africa
Prior art keywords
methylalanine
dihydroxyphenyl
esters
crystalline salts
crystalline
Prior art date
Application number
ZA846698A
Other languages
English (en)
Inventor
Edward J J Grabowski
William F Shukis
Arthur J Zambito
John Budavari
Robert F Czaja
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of ZA846698B publication Critical patent/ZA846698B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ZA846698A 1983-08-29 1984-08-28 Crystalline salts of l or(s)-3-(3,4-dihydroxyphenyl)-2-methylalanine esters and process ZA846698B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US52752683A 1983-08-29 1983-08-29

Publications (1)

Publication Number Publication Date
ZA846698B true ZA846698B (en) 1986-04-30

Family

ID=24101812

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA846698A ZA846698B (en) 1983-08-29 1984-08-28 Crystalline salts of l or(s)-3-(3,4-dihydroxyphenyl)-2-methylalanine esters and process

Country Status (14)

Country Link
EP (1) EP0139983B1 (de)
JP (1) JPS6072848A (de)
KR (1) KR900003530B1 (de)
AT (1) ATE30318T1 (de)
AU (1) AU575067B2 (de)
CA (1) CA1232614A (de)
DE (1) DE3466877D1 (de)
DK (1) DK409384A (de)
ES (1) ES8700226A1 (de)
GR (1) GR80155B (de)
IL (1) IL72726A (de)
NZ (1) NZ209285A (de)
PT (1) PT79107B (de)
ZA (1) ZA846698B (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA200610042B (en) * 2004-06-04 2008-06-25 Xenoport Inc Levodopa prodrugs, and compositions and uses thereof
US7709527B2 (en) * 2006-12-21 2010-05-04 Xenoport, Inc. Levodopa dimethyl-substituted diester prodrugs compositions, and methods of use

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3983138A (en) * 1973-09-25 1976-09-28 Merck & Co., Inc. Amino acid esters
US4404392A (en) * 1981-11-16 1983-09-13 Merck & Co., Inc. Resolution of α-pivaloyloxyethyl-(S)-3-(3,4-dihydroxyphenyl)-2-methylalantinate into its α and β isomers
US4440942A (en) * 1982-03-01 1984-04-03 Merck & Co., Inc. Crystalline diastereomeric L-alpha-methyldopa POE ester and process for its preparation

Also Published As

Publication number Publication date
ATE30318T1 (de) 1987-11-15
DK409384A (da) 1985-03-01
KR900003530B1 (ko) 1990-05-21
NZ209285A (en) 1988-04-29
ES8700226A1 (es) 1986-10-16
PT79107A (en) 1984-09-01
AU575067B2 (en) 1988-07-21
IL72726A (en) 1988-02-29
ES535444A0 (es) 1986-10-16
EP0139983A1 (de) 1985-05-08
CA1232614A (en) 1988-02-09
DE3466877D1 (en) 1987-11-26
DK409384D0 (da) 1984-08-28
KR850001729A (ko) 1985-04-01
GR80155B (en) 1984-12-19
JPS6072848A (ja) 1985-04-24
EP0139983B1 (de) 1987-10-21
IL72726A0 (en) 1984-11-30
AU3244884A (en) 1985-03-07
PT79107B (en) 1986-11-14

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