ZA816927B - 5-substituted 9-cyanomethylene-dithieno(3,4-b:4',3'-e)-azepines,their preparation,and therapeutic agents which contain these compounds - Google Patents
5-substituted 9-cyanomethylene-dithieno(3,4-b:4',3'-e)-azepines,their preparation,and therapeutic agents which contain these compoundsInfo
- Publication number
- ZA816927B ZA816927B ZA816927A ZA816927A ZA816927B ZA 816927 B ZA816927 B ZA 816927B ZA 816927 A ZA816927 A ZA 816927A ZA 816927 A ZA816927 A ZA 816927A ZA 816927 B ZA816927 B ZA 816927B
- Authority
- ZA
- South Africa
- Prior art keywords
- carbon atoms
- substituted
- nitrogen
- oxygen
- membered
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 239000003814 drug Substances 0.000 title 1
- 229940124597 therapeutic agent Drugs 0.000 title 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 20
- 125000004432 carbon atom Chemical group C* 0.000 abstract 18
- 229910052757 nitrogen Inorganic materials 0.000 abstract 12
- 125000000217 alkyl group Chemical group 0.000 abstract 8
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 6
- 229910052760 oxygen Inorganic materials 0.000 abstract 6
- 239000001301 oxygen Substances 0.000 abstract 6
- 239000002253 acid Substances 0.000 abstract 4
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 4
- 125000005842 heteroatom Chemical group 0.000 abstract 4
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 4
- 229920006395 saturated elastomer Polymers 0.000 abstract 4
- 150000001204 N-oxides Chemical class 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 150000001412 amines Chemical class 0.000 abstract 2
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 2
- 229910052794 bromium Inorganic materials 0.000 abstract 2
- 229910052801 chlorine Inorganic materials 0.000 abstract 2
- 239000000460 chlorine Substances 0.000 abstract 2
- 239000000470 constituent Substances 0.000 abstract 2
- 125000004981 cycloalkylmethyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- -1 5-substituted 9-cyanomethylene-dithieno-[3,4-b:4',3'-e]azepine Chemical class 0.000 abstract 1
- XYOVOXDWRFGKEX-UHFFFAOYSA-N azepine Chemical compound N1C=CC=CC=C1 XYOVOXDWRFGKEX-UHFFFAOYSA-N 0.000 abstract 1
- 239000012038 nucleophile Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19803037971 DE3037971A1 (de) | 1980-10-08 | 1980-10-08 | 5-substituierte 9-cyanmethylendithieno (3,4-b:4' 3'-e) -azepine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA816927B true ZA816927B (en) | 1982-10-27 |
Family
ID=6113891
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA816927A ZA816927B (en) | 1980-10-08 | 1981-10-07 | 5-substituted 9-cyanomethylene-dithieno(3,4-b:4',3'-e)-azepines,their preparation,and therapeutic agents which contain these compounds |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0050212B1 (en, 2012) |
| JP (1) | JPS5788179A (en, 2012) |
| AT (1) | ATE5820T1 (en, 2012) |
| CA (1) | CA1170258A (en, 2012) |
| DE (2) | DE3037971A1 (en, 2012) |
| DK (1) | DK152289C (en, 2012) |
| IE (1) | IE51635B1 (en, 2012) |
| ZA (1) | ZA816927B (en, 2012) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3309719A1 (de) * | 1983-03-18 | 1984-09-20 | Basf Ag, 6700 Ludwigshafen | 2,3,5,6-tetrasubstituierte p-benzochinone, ihre herstellung und verwendung |
| DE3524744A1 (de) * | 1985-07-11 | 1987-01-15 | Basf Ag | 4-substituierte 10-cyanmethylen-thieno (4,3-e)-benzo-azepine |
| DE3524743A1 (de) * | 1985-07-11 | 1987-01-15 | Basf Ag | Verfahren zur herstellung von 4,5-dihydro-dithieno-(3,4-b:4',3'-e)-azepin-5,9-dion |
| DE3717069A1 (de) * | 1987-05-21 | 1988-12-08 | Basf Ag | 5-substituierte 10-cyanmethylen-thieno(3,4-b)-benzo-azepine |
| DE3717068A1 (de) * | 1987-05-21 | 1988-12-08 | Basf Ag | 4-substituierte 10-cyanmethylen-pyrrolo(4,3-e)-benzo-azepine |
| WO2009139470A1 (ja) * | 2008-05-16 | 2009-11-19 | 学校法人聖マリアンナ医科大学 | 線維筋痛症治療用医薬組成物 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH560220A5 (en) * | 1971-11-26 | 1975-03-27 | Wander Ag Dr A | 4-(1-piperazinyl)-10h-thieno (3,2-c) (1) benzaepines - - antipsychotics, sedatives, hypnotics or muscle relaxants |
| DE2918778A1 (de) * | 1979-05-10 | 1980-11-20 | Basf Ag | 6-substituierte 11-alkylen-morphantridine |
-
1980
- 1980-10-08 DE DE19803037971 patent/DE3037971A1/de not_active Withdrawn
-
1981
- 1981-09-17 DE DE8181107343T patent/DE3161895D1/de not_active Expired
- 1981-09-17 AT AT81107343T patent/ATE5820T1/de not_active IP Right Cessation
- 1981-09-17 EP EP81107343A patent/EP0050212B1/de not_active Expired
- 1981-10-01 JP JP56154922A patent/JPS5788179A/ja active Granted
- 1981-10-06 IE IE2330/81A patent/IE51635B1/en unknown
- 1981-10-07 DK DK443881A patent/DK152289C/da active
- 1981-10-07 CA CA000387495A patent/CA1170258A/en not_active Expired
- 1981-10-07 ZA ZA816927A patent/ZA816927B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE3161895D1 (en) | 1984-02-16 |
| DK152289C (da) | 1988-07-11 |
| EP0050212A1 (de) | 1982-04-28 |
| EP0050212B1 (de) | 1984-01-11 |
| JPS5788179A (en) | 1982-06-01 |
| CA1170258A (en) | 1984-07-03 |
| JPH0243754B2 (en, 2012) | 1990-10-01 |
| IE51635B1 (en) | 1987-01-21 |
| DK152289B (da) | 1988-02-15 |
| IE812330L (en) | 1982-04-08 |
| DK443881A (da) | 1982-04-09 |
| ATE5820T1 (de) | 1984-01-15 |
| DE3037971A1 (de) | 1982-05-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NZ514709A (en) | Heterocyclic substituted 1,4-benzene dimethanamine derivatives useful for treating disorders mediated by chemokine receptor binding or associated with an abnormal immune response | |
| PH29998A (en) | Triazolopyridazine compounds their production and use | |
| IL103944A0 (en) | Piperazine derivatives,their preparation and pharmaceutical compositions containing them | |
| ES468267A1 (es) | Un procedimiento para la preparacion de nuevos derivados de acidos pirrol-1-carboxilicos | |
| PH23293A (en) | Hypotensive quinolone derivatives | |
| NZ232283A (en) | Substituted imidazo(1,2-b)pyridazine derivatives; pharmaceutical compositions and preparatory processes | |
| ZA816927B (en) | 5-substituted 9-cyanomethylene-dithieno(3,4-b:4',3'-e)-azepines,their preparation,and therapeutic agents which contain these compounds | |
| PL243329A1 (en) | Process for preparing novel derivatives of 7-beta-/(z)-2-/2-aminothiazolyl-4-/2-oxyiminoacetamido/-3-cephemo-4-carboxylic acid | |
| DE3170628D1 (en) | Piperidine derivatives, their preparation and use in medicine | |
| HUT37431A (en) | Process for the production of imidazo /1,2-c/pyrimidines and of their salts,as well as of therapeutic preparations containing these compounds as agent | |
| ES8706610A1 (es) | Proceso para preparar un derivado de aminoalcohol. | |
| EP0299076A4 (en) | 5-hydroxyindole-3-carboxamide compound and medicinal use thereof | |
| HUT50176A (en) | Process for production of derivatives of heterocyclic lactane and medical compositions containing them as active substance | |
| HU913293D0 (en) | Process for the production of pierazine derivatives and medical preparations containing them | |
| JPS5649385A (en) | Novel s-triazolo- 1,5-a -pyrimidine derivative | |
| GEP19970835B (en) | Process for obtaining 3-(methyltio, methylsulphinyl or methylsulphonyl)-4-quinolone | |
| GR3031538T3 (en) | Pyrido[3,4-b]pyrrolo[1,2-e][1,4,5]oxadiazepines and related analogs, a process for their preparation and their use as medicaments | |
| ES8800941A1 (es) | Un procedimiento para preparar derivados de dihidropirrol (112-b)-isoquinoleina | |
| CY1742A (en) | Mitomycin analogs a process for preparing them and pharmaceutical compositions | |
| JPS55143990A (en) | Preparation of novel diamine derivative, and thienodiazepin-2-one derivative containing the same | |
| PT71432A (en) | Clavulanic acid derivatives a process for their preparation and their use |