ZA805464B - 1-phenylthio-3-alkylamino-2-propanols,their acid addition salts,processes for their preparation and pharmaceutical compositions containing the same - Google Patents

1-phenylthio-3-alkylamino-2-propanols,their acid addition salts,processes for their preparation and pharmaceutical compositions containing the same

Info

Publication number
ZA805464B
ZA805464B ZA00805464A ZA805464A ZA805464B ZA 805464 B ZA805464 B ZA 805464B ZA 00805464 A ZA00805464 A ZA 00805464A ZA 805464 A ZA805464 A ZA 805464A ZA 805464 B ZA805464 B ZA 805464B
Authority
ZA
South Africa
Prior art keywords
general formula
see diagramm
represented
formula
phenylthio
Prior art date
Application number
ZA00805464A
Inventor
H Betzing
J Uhlendorf
H Gabbar
E Graf
I Doppelfeld
Original Assignee
Nattermann A & Cie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nattermann A & Cie filed Critical Nattermann A & Cie
Publication of ZA805464B publication Critical patent/ZA805464B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/25—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1. Claims for the contracting states BE, CH, LI, FR, GB, IT, LU, NL, SE 1-phenylthio-3-alkylamino-2-propanoles represented by the general formula I see diagramm : EP0025528,P9,F1 in which R1 is a straight chain or a branched C1 to C5 -alkyl or cycloalkyl group, and the physiologically acceptable acid addition salts thereof. 1. Claim for the contracting state AT A process for the production of 1-phenylthio-3-alkyl-amino-2-propanoles represented by the general formula I see diagramm : EP0025528,P10,F2 in which R1 is a straight chain or a branched C1 to C5 alkyl or cycloalkyl group, and its physiologically acceptable acid addition salts characterized in that, in a per se known manner, (a) an amine of the formula H2 N-R1 is reacted with an arylglycidsulfide represented by the general formula II see diagramm : EP0025528,P10,F3 or with a halogen hydrine represented by the general formula III see diagramm : EP0025528,P10,F4 wherein Hal is chlorine, bromine or iodine, or b) a thiophenole represented by the general formula IV see diagramm : EP0025528,P10,F5 is reacted with a compound of the formula X-CH2 -NH-R1 , wherein X represents the see diagramm : EP0025528,P11,F1 or Y-CH2 -CH(OH) group, wherein Y is a replaceable radical, or (c) a disulfide represented by the general formula V see diagramm : EP0025528,P11,F2 is under reducing conditions reacted with the partners indicated under (b), or (d) an amino derivative of the formula VI see diagramm : EP0025528,P11,F3 is allowed to react with an alkylhalogenide of the formula Hal-R1 , wherein R1 has the same meaning as in the general formula I.
ZA00805464A 1979-09-05 1980-09-04 1-phenylthio-3-alkylamino-2-propanols,their acid addition salts,processes for their preparation and pharmaceutical compositions containing the same ZA805464B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2935901A DE2935901C2 (en) 1979-09-05 1979-09-05 1- (2-Acetylphenylthio) -3-alkylamino-2-propanols and their acid addition salts, processes for their preparation and medicaments containing them

Publications (1)

Publication Number Publication Date
ZA805464B true ZA805464B (en) 1982-05-26

Family

ID=6080118

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA00805464A ZA805464B (en) 1979-09-05 1980-09-04 1-phenylthio-3-alkylamino-2-propanols,their acid addition salts,processes for their preparation and pharmaceutical compositions containing the same

Country Status (5)

Country Link
EP (1) EP0025528B1 (en)
JP (1) JPS5673058A (en)
AT (1) ATE2140T1 (en)
DE (1) DE2935901C2 (en)
ZA (1) ZA805464B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102015000666B4 (en) * 2015-01-23 2022-07-07 Franz Schneider Gmbh & Co. Kg Toy vehicle - excavator

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1236523C2 (en) * 1962-02-15 1975-06-12 Sanol-Arzneimittel Dr. Schwarz Gmbh, 4019 Monheim PROCESS FOR THE PRODUCTION OF BASIC PHENYLAETHERS AND THEIR SALTS
NL301580A (en) * 1962-12-11
DE2551141A1 (en) * 1975-11-14 1977-05-18 Dolorgiet Arzneimittelfabrik (1)-Cyclododecylamino'(2)-hydroxy-propane derivs. - selective beta-receptor blockers
DE2552266A1 (en) * 1975-11-21 1977-05-26 Dolorgiet Arzneimittelfabrik (1)-Aryloxy or arylthio-(3)-cyclohexylamino-(2)-propanol derivs. - prepd. e.g. by reacting epoxy propane cpds. with (3,3,5)-trimethyl-cyclohexylamine

Also Published As

Publication number Publication date
DE2935901C2 (en) 1983-06-01
EP0025528B1 (en) 1982-12-29
ATE2140T1 (en) 1983-01-15
DE2935901A1 (en) 1981-04-02
JPS5673058A (en) 1981-06-17
EP0025528A1 (en) 1981-03-25

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