ZA805464B - 1-phenylthio-3-alkylamino-2-propanols,their acid addition salts,processes for their preparation and pharmaceutical compositions containing the same - Google Patents
1-phenylthio-3-alkylamino-2-propanols,their acid addition salts,processes for their preparation and pharmaceutical compositions containing the sameInfo
- Publication number
- ZA805464B ZA805464B ZA00805464A ZA805464A ZA805464B ZA 805464 B ZA805464 B ZA 805464B ZA 00805464 A ZA00805464 A ZA 00805464A ZA 805464 A ZA805464 A ZA 805464A ZA 805464 B ZA805464 B ZA 805464B
- Authority
- ZA
- South Africa
- Prior art keywords
- general formula
- see diagramm
- represented
- formula
- phenylthio
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/25—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1. Claims for the contracting states BE, CH, LI, FR, GB, IT, LU, NL, SE 1-phenylthio-3-alkylamino-2-propanoles represented by the general formula I see diagramm : EP0025528,P9,F1 in which R1 is a straight chain or a branched C1 to C5 -alkyl or cycloalkyl group, and the physiologically acceptable acid addition salts thereof. 1. Claim for the contracting state AT A process for the production of 1-phenylthio-3-alkyl-amino-2-propanoles represented by the general formula I see diagramm : EP0025528,P10,F2 in which R1 is a straight chain or a branched C1 to C5 alkyl or cycloalkyl group, and its physiologically acceptable acid addition salts characterized in that, in a per se known manner, (a) an amine of the formula H2 N-R1 is reacted with an arylglycidsulfide represented by the general formula II see diagramm : EP0025528,P10,F3 or with a halogen hydrine represented by the general formula III see diagramm : EP0025528,P10,F4 wherein Hal is chlorine, bromine or iodine, or b) a thiophenole represented by the general formula IV see diagramm : EP0025528,P10,F5 is reacted with a compound of the formula X-CH2 -NH-R1 , wherein X represents the see diagramm : EP0025528,P11,F1 or Y-CH2 -CH(OH) group, wherein Y is a replaceable radical, or (c) a disulfide represented by the general formula V see diagramm : EP0025528,P11,F2 is under reducing conditions reacted with the partners indicated under (b), or (d) an amino derivative of the formula VI see diagramm : EP0025528,P11,F3 is allowed to react with an alkylhalogenide of the formula Hal-R1 , wherein R1 has the same meaning as in the general formula I.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2935901A DE2935901C2 (en) | 1979-09-05 | 1979-09-05 | 1- (2-Acetylphenylthio) -3-alkylamino-2-propanols and their acid addition salts, processes for their preparation and medicaments containing them |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA805464B true ZA805464B (en) | 1982-05-26 |
Family
ID=6080118
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA00805464A ZA805464B (en) | 1979-09-05 | 1980-09-04 | 1-phenylthio-3-alkylamino-2-propanols,their acid addition salts,processes for their preparation and pharmaceutical compositions containing the same |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0025528B1 (en) |
JP (1) | JPS5673058A (en) |
AT (1) | ATE2140T1 (en) |
DE (1) | DE2935901C2 (en) |
ZA (1) | ZA805464B (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102015000666B4 (en) * | 2015-01-23 | 2022-07-07 | Franz Schneider Gmbh & Co. Kg | Toy vehicle - excavator |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1236523C2 (en) * | 1962-02-15 | 1975-06-12 | Sanol-Arzneimittel Dr. Schwarz Gmbh, 4019 Monheim | PROCESS FOR THE PRODUCTION OF BASIC PHENYLAETHERS AND THEIR SALTS |
NL301580A (en) * | 1962-12-11 | |||
DE2551141A1 (en) * | 1975-11-14 | 1977-05-18 | Dolorgiet Arzneimittelfabrik | (1)-Cyclododecylamino'(2)-hydroxy-propane derivs. - selective beta-receptor blockers |
DE2552266A1 (en) * | 1975-11-21 | 1977-05-26 | Dolorgiet Arzneimittelfabrik | (1)-Aryloxy or arylthio-(3)-cyclohexylamino-(2)-propanol derivs. - prepd. e.g. by reacting epoxy propane cpds. with (3,3,5)-trimethyl-cyclohexylamine |
-
1979
- 1979-09-05 DE DE2935901A patent/DE2935901C2/en not_active Expired
-
1980
- 1980-08-27 EP EP80105102A patent/EP0025528B1/en not_active Expired
- 1980-08-27 AT AT80105102T patent/ATE2140T1/en not_active IP Right Cessation
- 1980-09-04 ZA ZA00805464A patent/ZA805464B/en unknown
- 1980-09-05 JP JP12340480A patent/JPS5673058A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
DE2935901C2 (en) | 1983-06-01 |
EP0025528B1 (en) | 1982-12-29 |
ATE2140T1 (en) | 1983-01-15 |
DE2935901A1 (en) | 1981-04-02 |
JPS5673058A (en) | 1981-06-17 |
EP0025528A1 (en) | 1981-03-25 |
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