ZA202205010B - High salt load conditioning during cation exchange chromatography to remove product-related impurities - Google Patents
High salt load conditioning during cation exchange chromatography to remove product-related impuritiesInfo
- Publication number
- ZA202205010B ZA202205010B ZA2022/05010A ZA202205010A ZA202205010B ZA 202205010 B ZA202205010 B ZA 202205010B ZA 2022/05010 A ZA2022/05010 A ZA 2022/05010A ZA 202205010 A ZA202205010 A ZA 202205010A ZA 202205010 B ZA202205010 B ZA 202205010B
- Authority
- ZA
- South Africa
- Prior art keywords
- cation exchange
- exchange chromatography
- high salt
- related impurities
- remove product
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies from serum
- C07K16/065—Purification, fragmentation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962931863P | 2019-11-07 | 2019-11-07 | |
| PCT/US2020/058772 WO2021091932A1 (en) | 2019-11-07 | 2020-11-04 | High salt load conditioning during cation exchange chromatography to remove product-realated impurities |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA202205010B true ZA202205010B (en) | 2023-01-25 |
Family
ID=73598211
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA2022/05010A ZA202205010B (en) | 2019-11-07 | 2022-05-06 | High salt load conditioning during cation exchange chromatography to remove product-related impurities |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20220372070A1 (enExample) |
| EP (1) | EP4055041A1 (enExample) |
| JP (2) | JP7760500B2 (enExample) |
| KR (1) | KR20220092969A (enExample) |
| CN (1) | CN114746441A (enExample) |
| AU (1) | AU2020380256A1 (enExample) |
| BR (1) | BR112022008649A2 (enExample) |
| CA (1) | CA3160143A1 (enExample) |
| CL (3) | CL2022001168A1 (enExample) |
| IL (1) | IL292594A (enExample) |
| MX (1) | MX2022005593A (enExample) |
| WO (1) | WO2021091932A1 (enExample) |
| ZA (1) | ZA202205010B (enExample) |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU7053500A (en) * | 1999-09-15 | 2001-04-17 | Eli Lilly And Company | Chymotrypsin-free trypsin |
| EP2001898A1 (en) | 2006-03-20 | 2008-12-17 | Medarex Inc. | Protein purification |
| EP2009101B1 (en) | 2006-03-31 | 2017-10-25 | Chugai Seiyaku Kabushiki Kaisha | Antibody modification method for purifying bispecific antibody |
| CN104628846B (zh) * | 2013-11-06 | 2019-12-06 | 三生国健药业（上海）股份有限公司 | 重组蛋白质的纯化方法 |
| US9611325B2 (en) | 2014-07-21 | 2017-04-04 | Wuhan Yzy Biopharma Co., Ltd. | Construction and application of bispecific antibody HER2xCD3 |
| CA2963692A1 (en) * | 2014-10-09 | 2016-04-14 | Engmab Ag | Bispecific antibodies against cd3epsilon and ror1 |
| JP6699085B2 (ja) * | 2015-03-25 | 2020-05-27 | 東ソー株式会社 | Ｆｃ結合性タンパク質の精製方法 |
| TW202600611A (zh) | 2017-11-01 | 2026-01-01 | 日商中外製藥股份有限公司 | 生物活性降低之抗體變異體與同功型 |
| CN110305217B (zh) * | 2018-03-27 | 2022-03-29 | 广州爱思迈生物医药科技有限公司 | 双特异性抗体及其应用 |
-
2020
- 2020-11-04 MX MX2022005593A patent/MX2022005593A/es unknown
- 2020-11-04 CN CN202080077935.3A patent/CN114746441A/zh active Pending
- 2020-11-04 US US17/773,886 patent/US20220372070A1/en active Pending
- 2020-11-04 WO PCT/US2020/058772 patent/WO2021091932A1/en not_active Ceased
- 2020-11-04 EP EP20812494.1A patent/EP4055041A1/en active Pending
- 2020-11-04 CA CA3160143A patent/CA3160143A1/en active Pending
- 2020-11-04 KR KR1020227018937A patent/KR20220092969A/ko active Pending
- 2020-11-04 JP JP2022525306A patent/JP7760500B2/ja active Active
- 2020-11-04 IL IL292594A patent/IL292594A/en unknown
- 2020-11-04 AU AU2020380256A patent/AU2020380256A1/en active Pending
- 2020-11-04 BR BR112022008649A patent/BR112022008649A2/pt not_active Application Discontinuation
-
2022
- 2022-05-04 CL CL2022001168A patent/CL2022001168A1/es unknown
- 2022-05-06 ZA ZA2022/05010A patent/ZA202205010B/en unknown
-
2024
- 2024-06-14 CL CL2024001788A patent/CL2024001788A1/es unknown
-
2025
- 2025-10-14 JP JP2025172458A patent/JP2026012744A/ja active Pending
- 2025-11-26 CL CL2025003712A patent/CL2025003712A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN114746441A (zh) | 2022-07-12 |
| MX2022005593A (es) | 2022-06-09 |
| JP2026012744A (ja) | 2026-01-27 |
| IL292594A (en) | 2022-07-01 |
| AU2020380256A1 (en) | 2022-06-09 |
| KR20220092969A (ko) | 2022-07-04 |
| JP7760500B2 (ja) | 2025-10-27 |
| CL2025003712A1 (es) | 2026-01-09 |
| CL2022001168A1 (es) | 2023-01-27 |
| JP2022554282A (ja) | 2022-12-28 |
| EP4055041A1 (en) | 2022-09-14 |
| US20220372070A1 (en) | 2022-11-24 |
| CL2024001788A1 (es) | 2024-09-27 |
| BR112022008649A2 (pt) | 2022-07-19 |
| WO2021091932A1 (en) | 2021-05-14 |
| CA3160143A1 (en) | 2021-05-14 |
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