ZA201502655B - Pyrazolopyridazines and methods for treating retinal-degenerative diseases and hearing loss associated with usher syndrome - Google Patents
Pyrazolopyridazines and methods for treating retinal-degenerative diseases and hearing loss associated with usher syndromeInfo
- Publication number
- ZA201502655B ZA201502655B ZA2015/02655A ZA201502655A ZA201502655B ZA 201502655 B ZA201502655 B ZA 201502655B ZA 2015/02655 A ZA2015/02655 A ZA 2015/02655A ZA 201502655 A ZA201502655 A ZA 201502655A ZA 201502655 B ZA201502655 B ZA 201502655B
- Authority
- ZA
- South Africa
- Prior art keywords
- pyrazolopyridazines
- methods
- hearing loss
- degenerative diseases
- loss associated
- Prior art date
Links
- NMEPLWZDUIIAAC-UHFFFAOYSA-N 1h-pyrazolo[4,3-c]pyridazine Chemical class C1=NN=C2C=NNC2=C1 NMEPLWZDUIIAAC-UHFFFAOYSA-N 0.000 title 1
- 206010011878 Deafness Diseases 0.000 title 1
- 208000014769 Usher Syndromes Diseases 0.000 title 1
- 230000010370 hearing loss Effects 0.000 title 1
- 231100000888 hearing loss Toxicity 0.000 title 1
- 208000016354 hearing loss disease Diseases 0.000 title 1
- 208000015122 neurodegenerative disease Diseases 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261718611P | 2012-10-25 | 2012-10-25 | |
| US201361775402P | 2013-03-08 | 2013-03-08 | |
| PCT/US2013/066939 WO2014066836A1 (en) | 2012-10-25 | 2013-10-25 | Pyrazolopyridazines and methods for treating retinal-degenerative diseases and hearing loss associated with usher syndrome |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA201502655B true ZA201502655B (en) | 2017-11-29 |
Family
ID=50545356
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA2015/02655A ZA201502655B (en) | 2012-10-25 | 2015-04-20 | Pyrazolopyridazines and methods for treating retinal-degenerative diseases and hearing loss associated with usher syndrome |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP2911671B1 (OSRAM) |
| JP (1) | JP6291502B2 (OSRAM) |
| AU (1) | AU2013334139B2 (OSRAM) |
| CA (1) | CA2889494C (OSRAM) |
| ES (1) | ES2687854T3 (OSRAM) |
| HU (1) | HUE039970T2 (OSRAM) |
| IL (1) | IL238288B (OSRAM) |
| PL (1) | PL2911671T3 (OSRAM) |
| WO (1) | WO2014066836A1 (OSRAM) |
| ZA (1) | ZA201502655B (OSRAM) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2012249801B2 (en) | 2011-04-25 | 2016-05-19 | Usher Iii Initiative, Inc. | Pyrazolopyridazines and methods for treating retinal-degenerative diseases and hearing loss associated with Usher syndrome |
| US9227976B2 (en) | 2012-10-25 | 2016-01-05 | Usher Iii Initiative, Inc. | Pyrazolopyridazines and methods for treating retinal-degenerative diseases and hearing loss associated with usher syndrome |
| CA2889537C (en) * | 2012-10-25 | 2017-12-12 | Usher Iii Initiative, Inc. | Pyrazolopyridazines and methods for treating retinal-degenerative diseases and hearing loss associated with usher syndrome |
| WO2017045955A1 (en) * | 2015-09-14 | 2017-03-23 | Basf Se | Heterobicyclic compounds |
| KR20200033249A (ko) | 2017-06-05 | 2020-03-27 | 피티씨 테라퓨틱스, 인크. | 헌팅턴병 치료 화합물 |
| US12103926B2 (en) | 2018-03-27 | 2024-10-01 | Ptc Therapeutics, Inc. | Compounds for treating huntington's disease |
| BR112020026545A2 (pt) * | 2018-06-27 | 2021-03-23 | Ptc Therapeutics, Inc. | Compostos heterocíclicos e de heteroarila para o tratamento da doença de huntington |
| EA202092899A1 (ru) | 2018-06-27 | 2021-05-14 | ПиТиСи ТЕРАПЬЮТИКС, ИНК. | Гетероарильные соединения для лечения болезни гентингтона |
| WO2020161208A1 (en) | 2019-02-06 | 2020-08-13 | Syngenta Crop Protection Ag | Herbicidal fused pyridazine compounds |
| WO2020161209A1 (en) | 2019-02-06 | 2020-08-13 | Syngenta Crop Protection Ag | Herbicidal fused pyridazine compounds |
| WO2023139091A1 (en) * | 2022-01-19 | 2023-07-27 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Geralexin and uses thereof for the treatment of retinal degenerative diseases |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0206723D0 (en) * | 2002-03-21 | 2002-05-01 | Glaxo Group Ltd | Novel compounds |
| WO2007075911A2 (en) * | 2005-12-22 | 2007-07-05 | Yale University | Inhibition of glycogen synthase kinase and methods of treating autoimmune or immune inflammatory disease |
| CN101917999A (zh) * | 2007-11-07 | 2010-12-15 | 弗尔德里克斯制药股份有限公司 | 蛋白质运输的调节 |
| AU2012249801B2 (en) * | 2011-04-25 | 2016-05-19 | Usher Iii Initiative, Inc. | Pyrazolopyridazines and methods for treating retinal-degenerative diseases and hearing loss associated with Usher syndrome |
| CA2889537C (en) * | 2012-10-25 | 2017-12-12 | Usher Iii Initiative, Inc. | Pyrazolopyridazines and methods for treating retinal-degenerative diseases and hearing loss associated with usher syndrome |
-
2013
- 2013-10-25 AU AU2013334139A patent/AU2013334139B2/en active Active
- 2013-10-25 PL PL13848995T patent/PL2911671T3/pl unknown
- 2013-10-25 JP JP2015539868A patent/JP6291502B2/ja active Active
- 2013-10-25 CA CA2889494A patent/CA2889494C/en active Active
- 2013-10-25 ES ES13848995.0T patent/ES2687854T3/es active Active
- 2013-10-25 EP EP13848995.0A patent/EP2911671B1/en active Active
- 2013-10-25 WO PCT/US2013/066939 patent/WO2014066836A1/en not_active Ceased
- 2013-10-25 HU HUE13848995A patent/HUE039970T2/hu unknown
-
2015
- 2015-04-14 IL IL238288A patent/IL238288B/en active IP Right Grant
- 2015-04-20 ZA ZA2015/02655A patent/ZA201502655B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUE039970T2 (hu) | 2019-02-28 |
| PL2911671T3 (pl) | 2018-11-30 |
| JP6291502B2 (ja) | 2018-03-14 |
| AU2013334139B2 (en) | 2017-08-03 |
| IL238288A0 (en) | 2015-06-30 |
| HK1214180A1 (en) | 2016-07-22 |
| AU2013334139A1 (en) | 2015-04-30 |
| WO2014066836A1 (en) | 2014-05-01 |
| EP2911671A1 (en) | 2015-09-02 |
| EP2911671A4 (en) | 2016-09-14 |
| CA2889494C (en) | 2018-12-18 |
| ES2687854T3 (es) | 2018-10-29 |
| IL238288B (en) | 2018-04-30 |
| EP2911671B1 (en) | 2018-06-27 |
| CA2889494A1 (en) | 2014-05-01 |
| JP2015535257A (ja) | 2015-12-10 |
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