ZA201201195B - Antibodies against the ectodomain of erbb3 and uses thereof - Google Patents

Antibodies against the ectodomain of erbb3 and uses thereof

Info

Publication number
ZA201201195B
ZA201201195B ZA2012/01195A ZA201201195A ZA201201195B ZA 201201195 B ZA201201195 B ZA 201201195B ZA 2012/01195 A ZA2012/01195 A ZA 2012/01195A ZA 201201195 A ZA201201195 A ZA 201201195A ZA 201201195 B ZA201201195 B ZA 201201195B
Authority
ZA
South Africa
Prior art keywords
ectodomain
erbb3
antibodies against
antibodies
Prior art date
Application number
ZA2012/01195A
Other languages
English (en)
Inventor
Birgit Schoeberl
Ulrik Nielsen
Michael Feldhaus
Original Assignee
Merrimack Pharmaceuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43607614&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA201201195(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merrimack Pharmaceuticals filed Critical Merrimack Pharmaceuticals
Publication of ZA201201195B publication Critical patent/ZA201201195B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA2012/01195A 2009-08-21 2012-02-17 Antibodies against the ectodomain of erbb3 and uses thereof ZA201201195B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23579909P 2009-08-21 2009-08-21
PCT/US2010/046364 WO2011022727A2 (en) 2009-08-21 2010-08-23 Antibodies against the ectodomain of erbb3 and uses thereof

Publications (1)

Publication Number Publication Date
ZA201201195B true ZA201201195B (en) 2015-07-29

Family

ID=43607614

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA2012/01195A ZA201201195B (en) 2009-08-21 2012-02-17 Antibodies against the ectodomain of erbb3 and uses thereof

Country Status (21)

Country Link
EP (1) EP2467164A2 (enrdf_load_html_response)
JP (1) JP5752687B2 (enrdf_load_html_response)
KR (1) KR20120059568A (enrdf_load_html_response)
CN (1) CN103002912A (enrdf_load_html_response)
AU (1) AU2010284018C1 (enrdf_load_html_response)
BR (1) BR112012003809A2 (enrdf_load_html_response)
CA (1) CA2771744A1 (enrdf_load_html_response)
CR (1) CR20120108A (enrdf_load_html_response)
DO (1) DOP2012000044A (enrdf_load_html_response)
EA (1) EA201200195A1 (enrdf_load_html_response)
EC (1) ECSP12011740A (enrdf_load_html_response)
IL (1) IL218097A0 (enrdf_load_html_response)
IN (1) IN2012DN01518A (enrdf_load_html_response)
MA (1) MA33582B1 (enrdf_load_html_response)
MX (1) MX336091B (enrdf_load_html_response)
NI (1) NI201200027A (enrdf_load_html_response)
PE (1) PE20121585A1 (enrdf_load_html_response)
SG (1) SG178509A1 (enrdf_load_html_response)
TN (1) TN2012000057A1 (enrdf_load_html_response)
WO (1) WO2011022727A2 (enrdf_load_html_response)
ZA (1) ZA201201195B (enrdf_load_html_response)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20131113T1 (hr) 2007-02-16 2014-01-17 Merrimack Pharmaceuticals, Inc. Protutijela protiv erbb3 i njihova uporaba
SI3351558T1 (sl) * 2009-11-13 2020-07-31 Daiichi Sankyo Europe Gmbh Material in postopki za zdravljenje ali preprečevanje bolezni, povezanih s HER-3
US8859737B2 (en) 2009-12-22 2014-10-14 Roche Glycart Ag Anti-HER3 antibodies and uses thereof
ES2535503T3 (es) 2010-03-11 2015-05-12 Merrimack Pharmaceuticals, Inc. Uso de inhibidores de ErbB3 en el tratamiento del cáncer de mama triple negativo
RU2568051C2 (ru) 2010-04-09 2015-11-10 Авео Фармасьютикалз, Инк. АНТИТЕЛА К ErbB3
PL2606070T4 (pl) 2010-08-20 2017-06-30 Novartis Ag Przeciwciała dla receptora epidermalnego czynnika wzrostu 3 (her3)
TW201302793A (zh) 2010-09-03 2013-01-16 Glaxo Group Ltd 新穎之抗原結合蛋白
IT1402149B1 (it) * 2010-10-04 2013-08-28 Ist Fisioterap Ospitalroma Uso di un fosfopeptide in grado di bloccare l interazione her3/p85 per il trattamento dei tumori iperesprimenti her2.
EP3156421B1 (en) * 2010-11-01 2018-06-06 Symphogen A/S Pan-her antibody composition
EP2699602B1 (en) 2011-04-19 2017-03-01 Merrimack Pharmaceuticals, Inc. Bispecific anti-igf-1r and anti-erbb3 antibodies
CA2840461A1 (en) * 2011-06-20 2012-12-27 Kyowa Hakko Kirin Co., Ltd. Anti-erbb3 antibody
ES2694153T3 (es) 2011-09-30 2018-12-18 Regeneron Pharmaceuticals, Inc. Anticuerpos anti-ErbB3 y usos de los mismos
US9273143B2 (en) 2011-09-30 2016-03-01 Regeneron Pharmaceuticals, Inc. Methods and compositions comprising a combination of an anti-ErbB3 antibody and an anti-EGFR antibody
CN108753942A (zh) 2011-10-06 2018-11-06 Aveo制药公司 预测肿瘤对抗erbb3抗体的应答
AU2012335543C1 (en) * 2011-11-09 2017-12-14 Beijing Cotimes Biotech Co., Ltd., HER3 antibodies and uses thereof
UY34487A (es) 2011-12-05 2013-07-31 Novartis Ag Anticuerpos para receptor de factor de crecimiento epidérmico 3(her3)
HK1201278A1 (en) * 2012-02-22 2015-08-28 U3 Pharma Gmbh Combination of hb-egf binding protein and egfr inhibitor
AR094403A1 (es) 2013-01-11 2015-07-29 Hoffmann La Roche Terapia de combinación de anticuerpos anti-her3
WO2015058108A1 (en) * 2013-10-17 2015-04-23 Sanford-Burnham Medical Research Institute Drug sensitivity biomarkers and methods of identifying and using drug sensitivity biomarkers
WO2015100459A2 (en) 2013-12-27 2015-07-02 Merrimack Pharmaceuticals, Inc. Biomarker profiles for predicting outcomes of cancer therapy with erbb3 inhibitors and/or chemotherapies
NZ724013A (en) 2014-02-28 2019-11-29 Merus Nv Antibodies that bind egfr and erbb3
CN105367657B (zh) * 2014-08-14 2019-09-13 上海生物制品研究所有限责任公司 抗her3抗体、其制法及其应用
WO2016038609A1 (en) * 2014-09-08 2016-03-17 Yeda Research And Development Co. Ltd. Anti-her3 antibodies and uses of same
JP2017534574A (ja) 2014-09-08 2017-11-24 イェダ リサーチ アンド ディベロップメント カンパニー リミテッドＹｅｄａ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｄｅｖｅｌｏｐｍｅｎｔ Ｃｏ．Ｌｔｄ． チロシンキナーゼ阻害薬（ｔｋｉ）に耐性のがんを処置するための組成物および方法
US10184006B2 (en) 2015-06-04 2019-01-22 Merrimack Pharmaceuticals, Inc. Biomarkers for predicting outcomes of cancer therapy with ErbB3 inhibitors
BR112018008068A2 (pt) 2015-10-23 2018-11-13 Merus N.V. moléculas de ligação que inibem o crescimento do câncer
EP3600413A1 (en) 2017-03-31 2020-02-05 Merus N.V. Erbb-2 and erbb3 binding bispecific antibodies for use in the treatment f cells that have an nrg1 fusion gene
ES2951864T3 (es) 2017-05-17 2023-10-25 Merus Nv Combinación de un anticuerpo biespecífico ERBB-2/ERBB-3 con terapia endocrina para el cáncer de mama
US11390686B2 (en) 2017-08-09 2022-07-19 University Of Saskatchewan HER3 binding agents and uses thereof
FI3665198T3 (fi) 2017-08-09 2025-04-25 Merus Nv EGFR:ää ja cMET:tä sitovia vasta-aineita
GB201804094D0 (en) * 2018-03-14 2018-04-25 Ultrahuman Thirteen Ltd ERBB3 Binding agents
JP2021534811A (ja) * 2018-06-22 2021-12-16 シーアールディー ファーマシューティカルズ インコーポレイティド 抗ｈｅｒ３抗体およびその用途
CN116133694A (zh) * 2020-10-14 2023-05-16 江苏恒瑞医药股份有限公司 抗her3抗体和抗her3抗体药物偶联物及其医药用途
CA3199259A1 (en) * 2020-11-20 2022-05-27 Dale L Ludwig Her3 radioimmunotherapy for the treatment of solid cancers
JP2024523885A (ja) * 2021-06-15 2024-07-02 ベイジン・シノタウ・バイオ－ファーマシューティカルズ・テクノロジー・カンパニー，リミテッド 抗ｈｅｒ３抗体、それを含有する抗体薬物複合体及びそれらの用途
CN119013307A (zh) * 2022-04-13 2024-11-22 上海翰森生物医药科技有限公司 抗体或其抗原结合片段及其医药用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20131113T1 (hr) * 2007-02-16 2014-01-17 Merrimack Pharmaceuticals, Inc. Protutijela protiv erbb3 i njihova uporaba

Also Published As

Publication number Publication date
JP2013506622A (ja) 2013-02-28
TN2012000057A1 (en) 2013-09-19
MX336091B (es) 2016-01-08
SG178509A1 (en) 2012-04-27
CR20120108A (es) 2012-06-05
CN103002912A (zh) 2013-03-27
AU2010284018B2 (en) 2014-06-05
KR20120059568A (ko) 2012-06-08
MX2012002172A (es) 2012-05-29
EA201200195A1 (ru) 2012-12-28
WO2011022727A3 (en) 2013-06-27
JP5752687B2 (ja) 2015-07-22
IL218097A0 (en) 2012-04-30
IN2012DN01518A (enrdf_load_html_response) 2015-06-05
AU2010284018A1 (en) 2012-03-22
AU2010284018C1 (en) 2015-10-15
CA2771744A1 (en) 2011-02-24
WO2011022727A2 (en) 2011-02-24
EP2467164A2 (en) 2012-06-27
BR112012003809A2 (pt) 2019-09-24
NI201200027A (es) 2013-01-29
ECSP12011740A (es) 2013-02-28
DOP2012000044A (es) 2012-06-30
PE20121585A1 (es) 2012-11-29
MA33582B1 (fr) 2012-09-01

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