ZA201101836B - Process for the preparation of rufinamide - Google Patents
Process for the preparation of rufinamideInfo
- Publication number
- ZA201101836B ZA201101836B ZA2011/01836A ZA201101836A ZA201101836B ZA 201101836 B ZA201101836 B ZA 201101836B ZA 2011/01836 A ZA2011/01836 A ZA 2011/01836A ZA 201101836 A ZA201101836 A ZA 201101836A ZA 201101836 B ZA201101836 B ZA 201101836B
- Authority
- ZA
- South Africa
- Prior art keywords
- rufinamide
- preparation
- Prior art date
Links
- POGQSBRIGCQNEG-UHFFFAOYSA-N rufinamide Chemical compound N1=NC(C(=O)N)=CN1CC1=C(F)C=CC=C1F POGQSBRIGCQNEG-UHFFFAOYSA-N 0.000 title 1
- 229960003014 rufinamide Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4192—1,2,3-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN2190MU2008 | 2008-10-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA201101836B true ZA201101836B (en) | 2011-10-26 |
Family
ID=41786401
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA2011/01836A ZA201101836B (en) | 2008-10-13 | 2011-03-10 | Process for the preparation of rufinamide |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8183269B2 (enExample) |
| EP (1) | EP2334653A1 (enExample) |
| JP (2) | JP2012505191A (enExample) |
| KR (1) | KR20110067022A (enExample) |
| AU (1) | AU2009305255B2 (enExample) |
| CA (1) | CA2736703A1 (enExample) |
| NZ (1) | NZ591725A (enExample) |
| WO (1) | WO2010043849A1 (enExample) |
| ZA (1) | ZA201101836B (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ591725A (en) | 2008-10-13 | 2012-09-28 | Cipla Ltd | PROCESS FOR THE PREPARATION OF RUFINAMIDE which is also known as 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide |
| WO2011135105A1 (en) | 2010-04-30 | 2011-11-03 | Laboratorios Lesvi, S.L. | Improved process for preparing rufinamide intermediate |
| JP6108112B2 (ja) * | 2010-08-25 | 2017-04-05 | ラオ ダヴルリ，ラマモハン | 改良されたルフィナミド調製プロセス |
| WO2012032540A1 (en) | 2010-09-06 | 2012-03-15 | Indoco Remedies Limited | Process for preparation of fluorinated triazole compound |
| CN102219752B (zh) * | 2011-04-21 | 2013-04-10 | 华润赛科药业有限责任公司 | 一种1-(2,6-二氟苄基)-1h-1,2,3-三唑-4-甲酰胺的晶型d |
| US20140357871A1 (en) | 2012-01-10 | 2014-12-04 | Lupin Limited | Process for preparation of rufinamide |
| CN103539750A (zh) * | 2012-07-09 | 2014-01-29 | 旭和（天津）医药科技有限公司 | 一种合成卢非酰胺的工艺 |
| WO2014072992A1 (en) | 2012-11-12 | 2014-05-15 | Aarti Industries Limited | A process for preparing triazole compounds |
| WO2014120994A1 (en) * | 2013-01-31 | 2014-08-07 | The Johns Hopkins University | Rufinamide and derivatives and their use in modulating the gating process of human voltage-gated sodium channels |
| WO2014121383A1 (en) * | 2013-02-11 | 2014-08-14 | Apotex Technologies Inc. | A process for the preparation of rufinamide and intermediates thereof |
| KR20190081386A (ko) | 2017-12-29 | 2019-07-09 | 강원대학교산학협력단 | 루핀아마이드를 유효성분으로 함유하는 허혈성 뇌혈관 질환 예방용 조성물 |
| CN109438374B (zh) * | 2018-10-10 | 2020-10-30 | 凯莱英医药集团（天津）股份有限公司 | 卢非酰胺的连续化合成方法 |
| US20230026724A1 (en) * | 2019-10-11 | 2023-01-26 | Chengdu Mfs Pharma. Co., Ltd. | Substituted nitrogen heterocyclic compound and anesthetic effect thereof |
| CN114106211A (zh) * | 2021-08-31 | 2022-03-01 | 海南医学院 | 一种云南鸡油菌多糖及其分离纯化方法 |
| CN116854644B (zh) * | 2023-07-06 | 2025-10-21 | 浙江大学 | 5-氨基-1-烷基-1h-1,2,3-三氮唑-4-甲酰胺类化合物及其制备和应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4789680A (en) * | 1982-12-23 | 1988-12-06 | Ciba-Geigy Corporation | Aralkyltriazole compounds |
| SK283990B6 (sk) | 1996-07-11 | 2004-07-07 | Novartis Ag | Spôsob prípravy 1-substituovaných 4-kyano-1,2,3-triazolov, 4-kyano-1-(2,6-difluórbenzyl)-1H-1,2,3-triazol |
| TW403740B (en) * | 1997-06-10 | 2000-09-01 | Novartis Ag | Novel crystal modifications of the compound 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide |
| NZ591725A (en) | 2008-10-13 | 2012-09-28 | Cipla Ltd | PROCESS FOR THE PREPARATION OF RUFINAMIDE which is also known as 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide |
-
2009
- 2009-10-09 NZ NZ591725A patent/NZ591725A/xx not_active IP Right Cessation
- 2009-10-09 JP JP2011530559A patent/JP2012505191A/ja active Pending
- 2009-10-09 US US13/063,440 patent/US8183269B2/en not_active Expired - Fee Related
- 2009-10-09 AU AU2009305255A patent/AU2009305255B2/en not_active Ceased
- 2009-10-09 WO PCT/GB2009/002419 patent/WO2010043849A1/en not_active Ceased
- 2009-10-09 CA CA2736703A patent/CA2736703A1/en not_active Abandoned
- 2009-10-13 KR KR1020117006738A patent/KR20110067022A/ko not_active Ceased
- 2009-10-13 EP EP09744712A patent/EP2334653A1/en not_active Withdrawn
-
2011
- 2011-03-10 ZA ZA2011/01836A patent/ZA201101836B/en unknown
-
2014
- 2014-11-28 JP JP2014240724A patent/JP2015096515A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US8183269B2 (en) | 2012-05-22 |
| JP2012505191A (ja) | 2012-03-01 |
| JP2015096515A (ja) | 2015-05-21 |
| AU2009305255A8 (en) | 2011-08-25 |
| KR20110067022A (ko) | 2011-06-20 |
| AU2009305255B2 (en) | 2014-02-06 |
| AU2009305255A1 (en) | 2010-04-22 |
| CA2736703A1 (en) | 2010-04-22 |
| NZ591725A (en) | 2012-09-28 |
| WO2010043849A8 (en) | 2011-06-30 |
| US20110207938A1 (en) | 2011-08-25 |
| EP2334653A1 (en) | 2011-06-22 |
| WO2010043849A1 (en) | 2010-04-22 |
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