NZ591725A - PROCESS FOR THE PREPARATION OF RUFINAMIDE which is also known as 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide - Google Patents

PROCESS FOR THE PREPARATION OF RUFINAMIDE which is also known as 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide

Info

Publication number
NZ591725A
NZ591725A NZ591725A NZ59172509A NZ591725A NZ 591725 A NZ591725 A NZ 591725A NZ 591725 A NZ591725 A NZ 591725A NZ 59172509 A NZ59172509 A NZ 59172509A NZ 591725 A NZ591725 A NZ 591725A
Authority
NZ
New Zealand
Prior art keywords
rufinamide
formula
difluorobenzyl
triazole
preparation
Prior art date
Application number
NZ591725A
Other languages
English (en)
Inventor
Rajendra Narayanrao Kankan
Dharmaraj Ramachandra Rao
Dilip Ramdas Birari
Original Assignee
Cipla Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cipla Ltd filed Critical Cipla Ltd
Publication of NZ591725A publication Critical patent/NZ591725A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NZ591725A 2008-10-13 2009-10-09 PROCESS FOR THE PREPARATION OF RUFINAMIDE which is also known as 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide NZ591725A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2190MU2008 2008-10-13
PCT/GB2009/002419 WO2010043849A1 (en) 2008-10-13 2009-10-09 Process for the preparation of rufinamide

Publications (1)

Publication Number Publication Date
NZ591725A true NZ591725A (en) 2012-09-28

Family

ID=41786401

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ591725A NZ591725A (en) 2008-10-13 2009-10-09 PROCESS FOR THE PREPARATION OF RUFINAMIDE which is also known as 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide

Country Status (9)

Country Link
US (1) US8183269B2 (enExample)
EP (1) EP2334653A1 (enExample)
JP (2) JP2012505191A (enExample)
KR (1) KR20110067022A (enExample)
AU (1) AU2009305255B2 (enExample)
CA (1) CA2736703A1 (enExample)
NZ (1) NZ591725A (enExample)
WO (1) WO2010043849A1 (enExample)
ZA (1) ZA201101836B (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012505191A (ja) 2008-10-13 2012-03-01 シプラ・リミテッド ルフィナマイドの製造方法
WO2011135105A1 (en) 2010-04-30 2011-11-03 Laboratorios Lesvi, S.L. Improved process for preparing rufinamide intermediate
WO2012025936A2 (en) 2010-08-25 2012-03-01 Ramamohan Rao Davuluri Improved process for the preparation of rufinamide
WO2012032540A1 (en) 2010-09-06 2012-03-15 Indoco Remedies Limited Process for preparation of fluorinated triazole compound
CN102219752B (zh) * 2011-04-21 2013-04-10 华润赛科药业有限责任公司 一种1-(2,6-二氟苄基)-1h-1,2,3-三唑-4-甲酰胺的晶型d
US20140357871A1 (en) 2012-01-10 2014-12-04 Lupin Limited Process for preparation of rufinamide
CN103539750A (zh) * 2012-07-09 2014-01-29 旭和（天津）医药科技有限公司 一种合成卢非酰胺的工艺
WO2014072992A1 (en) 2012-11-12 2014-05-15 Aarti Industries Limited A process for preparing triazole compounds
WO2014120994A1 (en) * 2013-01-31 2014-08-07 The Johns Hopkins University Rufinamide and derivatives and their use in modulating the gating process of human voltage-gated sodium channels
WO2014121383A1 (en) * 2013-02-11 2014-08-14 Apotex Technologies Inc. A process for the preparation of rufinamide and intermediates thereof
KR20190081386A (ko) 2017-12-29 2019-07-09 강원대학교산학협력단 루핀아마이드를 유효성분으로 함유하는 허혈성 뇌혈관 질환 예방용 조성물
CN109438374B (zh) * 2018-10-10 2020-10-30 凯莱英医药集团（天津）股份有限公司 卢非酰胺的连续化合成方法
EP4043440A4 (en) * 2019-10-11 2023-11-08 Chengdu Mfs Pharma. Co., Ltd. SUBSTITUTED NITROGEN HETEROCYCLE COMPOUND AND ANESTHESIZING EFFECT THEREOF
CN114106211A (zh) * 2021-08-31 2022-03-01 海南医学院 一种云南鸡油菌多糖及其分离纯化方法
CN116854644B (zh) * 2023-07-06 2025-10-21 浙江大学 5-氨基-1-烷基-1h-1,2,3-三氮唑-4-甲酰胺类化合物及其制备和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4789680A (en) * 1982-12-23 1988-12-06 Ciba-Geigy Corporation Aralkyltriazole compounds
US6156907A (en) 1996-07-11 2000-12-05 Novartis Ag Process for preparing 1-substituted 4-cyano-1,2,3-triazoles
TW403740B (en) * 1997-06-10 2000-09-01 Novartis Ag Novel crystal modifications of the compound 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide
JP2012505191A (ja) 2008-10-13 2012-03-01 シプラ・リミテッド ルフィナマイドの製造方法

Also Published As

Publication number Publication date
EP2334653A1 (en) 2011-06-22
KR20110067022A (ko) 2011-06-20
AU2009305255A1 (en) 2010-04-22
US20110207938A1 (en) 2011-08-25
WO2010043849A8 (en) 2011-06-30
JP2012505191A (ja) 2012-03-01
AU2009305255B2 (en) 2014-02-06
AU2009305255A8 (en) 2011-08-25
US8183269B2 (en) 2012-05-22
CA2736703A1 (en) 2010-04-22
WO2010043849A1 (en) 2010-04-22
JP2015096515A (ja) 2015-05-21
ZA201101836B (en) 2011-10-26

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Free format text: PATENT RENEWED FOR 3 YEARS UNTIL 09 OCT 2016 BY CPA GLOBAL

Effective date: 20130829

LAPS Patent lapsed