ZA201005959B - 4-(pyrrolo[2,3-c]pyridine-3-yl)-pyrimidine-2-amine derivatives - Google Patents

4-(pyrrolo[2,3-c]pyridine-3-yl)-pyrimidine-2-amine derivatives

Info

Publication number
ZA201005959B
ZA201005959B ZA2010/05959A ZA201005959A ZA201005959B ZA 201005959 B ZA201005959 B ZA 201005959B ZA 2010/05959 A ZA2010/05959 A ZA 2010/05959A ZA 201005959 A ZA201005959 A ZA 201005959A ZA 201005959 B ZA201005959 B ZA 201005959B
Authority
ZA
South Africa
Prior art keywords
pyrrolo
pyrimidine
pyridine
amine derivatives
amine
Prior art date
Application number
ZA2010/05959A
Other languages
English (en)
Inventor
Thomas J J Mueller
Eugen Merkul
Christian Sirrenberg
Dieter Dorsch
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of ZA201005959B publication Critical patent/ZA201005959B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ZA2010/05959A 2008-01-22 2010-08-20 4-(pyrrolo[2,3-c]pyridine-3-yl)-pyrimidine-2-amine derivatives ZA201005959B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102008005493A DE102008005493A1 (de) 2008-01-22 2008-01-22 4-(Pyrrolo[2,3-c] pyridine-3-yl)-pyrimidin-2-yl-amin-derivate
PCT/EP2008/011098 WO2009092431A1 (de) 2008-01-22 2008-12-23 4-(pyrrolo[2,3-c]pyridine-3-yl)-pyrimidin-2-amin-derivative

Publications (1)

Publication Number Publication Date
ZA201005959B true ZA201005959B (en) 2011-04-28

Family

ID=40386204

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA2010/05959A ZA201005959B (en) 2008-01-22 2010-08-20 4-(pyrrolo[2,3-c]pyridine-3-yl)-pyrimidine-2-amine derivatives

Country Status (14)

Country Link
US (1) US20100292262A1 (https=)
EP (1) EP2231664A1 (https=)
JP (1) JP5524864B2 (https=)
KR (1) KR20100112626A (https=)
CN (1) CN101918404A (https=)
AR (1) AR070212A1 (https=)
AU (1) AU2008348816B2 (https=)
BR (1) BRPI0821936A2 (https=)
CA (1) CA2712612A1 (https=)
DE (1) DE102008005493A1 (https=)
IL (1) IL206905A0 (https=)
MX (1) MX2010007927A (https=)
WO (1) WO2009092431A1 (https=)
ZA (1) ZA201005959B (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101723936B (zh) * 2008-10-27 2014-01-15 上海睿星基因技术有限公司 激酶抑制剂及其在药学中的用途
JP2014515368A (ja) 2011-05-26 2014-06-30 第一三共株式会社 プロテインキナーゼ阻害剤としての複素環化合物
NZ746607A (en) 2012-11-21 2019-11-29 Ptc Therapeutics Inc Substituted reverse pyrimidine bmi-1 inhibitors
TWI663166B (zh) 2013-04-24 2019-06-21 健生藥品公司 新化合物
EA034866B1 (ru) 2013-08-30 2020-03-31 ПиТиСи ТЕРАПЬЮТИКС, ИНК. Замещенные пиримидиновые ингибиторы bmi-1
TWI704146B (zh) 2013-09-26 2020-09-11 比利時商健生藥品公司 用作ＮＩＫ抑制劑之新的1-(４-嘧啶基)-１Ｈ-吡唑並[３,２-ｃ]吡啶衍生物
TWI627173B (zh) 2013-09-26 2018-06-21 比利時商健生藥品公司 作為ＮＩＫ抑制劑的新穎３－（１Ｈ－吡唑－４－基）－１Ｈ－吡咯并［２，３－ｃ］吡啶衍生物
WO2015076800A1 (en) 2013-11-21 2015-05-28 Ptc Therapeutics, Inc. Substituted pyridine and pyrazine bmi-1 inhibitors
CA2960336C (en) * 2014-10-23 2023-03-07 Janssen Pharmaceutica Nv Compounds as nik inhibitors
EA033238B1 (ru) 2014-10-23 2019-09-30 Янссен Фармацевтика Нв Новые производные тиенопиримидина в качестве ингибиторов nik
KR102523405B1 (ko) 2014-10-23 2023-04-18 얀센 파마슈티카 엔.브이. Ｎｉｋ 억제제로서의 신규 피라졸로피리미딘 유도체
EP3209654B1 (en) 2014-10-23 2018-10-03 Janssen Pharmaceutica N.V. New pyrazole derivatives as nik inhibitors
EP3836932A2 (en) 2018-08-17 2021-06-23 PTC Therapeutics, Inc. Method for treating pancreatic cancer

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5747469A (en) 1991-03-06 1998-05-05 Board Of Regents, The University Of Texas System Methods and compositions comprising DNA damaging agents and p53
GB9904387D0 (en) 1999-02-25 1999-04-21 Pharmacia & Upjohn Spa Antitumour synergistic composition
GB0308466D0 (en) 2003-04-11 2003-05-21 Novartis Ag Organic compounds
JP2008502687A (ja) * 2004-06-14 2008-01-31 タケダ サン ディエゴ インコーポレイテッド キナーゼ阻害剤
WO2006050076A1 (en) 2004-10-29 2006-05-11 Janssen Pharmaceutica, N.V. Pyrimidinyl substituted fused-pyrrolyl compounds useful in treating kinase disorders
ZA200802685B (en) * 2005-09-30 2009-10-28 Vertex Pharma Deazapurines useful as inhibitors of janus kinases
DE102006012617A1 (de) * 2006-03-20 2007-09-27 Merck Patent Gmbh 4-(Pyrrolopyridinyl)-pyrimidinyl-2-amin-derivate

Also Published As

Publication number Publication date
AR070212A1 (es) 2010-03-25
JP5524864B2 (ja) 2014-06-18
US20100292262A1 (en) 2010-11-18
DE102008005493A8 (de) 2010-03-25
DE102008005493A1 (de) 2009-07-23
MX2010007927A (es) 2010-08-09
KR20100112626A (ko) 2010-10-19
CN101918404A (zh) 2010-12-15
WO2009092431A1 (de) 2009-07-30
CA2712612A1 (en) 2009-07-30
AU2008348816B2 (en) 2011-10-20
AU2008348816A1 (en) 2009-07-30
EP2231664A1 (de) 2010-09-29
BRPI0821936A2 (pt) 2015-06-16
JP2011510028A (ja) 2011-03-31
IL206905A0 (en) 2010-12-30

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