ZA200905874B - Monoclonal human tumor-specific antibody - Google Patents

Monoclonal human tumor-specific antibody

Info

Publication number
ZA200905874B
ZA200905874B ZA200905874A ZA200905874A ZA200905874B ZA 200905874 B ZA200905874 B ZA 200905874B ZA 200905874 A ZA200905874 A ZA 200905874A ZA 200905874 A ZA200905874 A ZA 200905874A ZA 200905874 B ZA200905874 B ZA 200905874B
Authority
ZA
South Africa
Prior art keywords
specific antibody
human tumor
monoclonal human
monoclonal
tumor
Prior art date
Application number
ZA200905874A
Other languages
English (en)
Inventor
Christoph Esslinger
Norbert Goebels
Sandra Kuenzle
Irene Abela
Alfred Zippelius
Dirk Jaeger
Alexander Knuth
Roger M D Nitsch
Holger Moch
Original Assignee
Univ Zuerich
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Zuerich filed Critical Univ Zuerich
Publication of ZA200905874B publication Critical patent/ZA200905874B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/0002General or multifunctional contrast agents, e.g. chelated agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3053Skin, nerves, brain
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Oncology (AREA)
  • Neurology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Mycology (AREA)
  • Food Science & Technology (AREA)
  • Plant Pathology (AREA)
ZA200905874A 2007-03-13 2009-08-25 Monoclonal human tumor-specific antibody ZA200905874B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP07005180 2007-03-13

Publications (1)

Publication Number Publication Date
ZA200905874B true ZA200905874B (en) 2010-04-28

Family

ID=39627674

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200905874A ZA200905874B (en) 2007-03-13 2009-08-25 Monoclonal human tumor-specific antibody

Country Status (19)

Country Link
US (2) US8519106B2 (zh)
EP (4) EP2457928B1 (zh)
JP (2) JP2010520760A (zh)
KR (1) KR101570702B1 (zh)
CN (1) CN101652388B (zh)
AU (1) AU2008225994B9 (zh)
BR (1) BRPI0808940B8 (zh)
CA (1) CA2680914C (zh)
DK (1) DK2457928T3 (zh)
ES (2) ES2523194T3 (zh)
HU (1) HUE035762T2 (zh)
IL (1) IL200615A (zh)
MX (1) MX2009009926A (zh)
NZ (1) NZ579520A (zh)
PL (2) PL2134746T3 (zh)
PT (1) PT2457928T (zh)
RU (1) RU2488593C2 (zh)
WO (2) WO2008110373A1 (zh)
ZA (1) ZA200905874B (zh)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL199534A (en) 2007-01-05 2013-01-31 Univ Zuerich An isolated human antibody capable of detecting a neoepitope in a disease-related protein, a polynucleotide encoding an antibody, a vector containing the polynucleotide, a host cell containing the polynucleotide or vector, a preparation containing the antibody and related methods and uses.
EP2186827A1 (en) 2008-11-14 2010-05-19 HS LifeSciences Ltd. Surrogate marker directed cDNA cloning of selectively induced mRNAs
JP5810413B2 (ja) 2008-12-19 2015-11-11 バイオジェン インターナショナル ニューロサイエンス ゲーエムベーハー ヒト抗アルファシヌクレイン自己抗体
CA2781248A1 (en) * 2009-11-18 2011-05-26 Mannkind Corporation Monoclonal antibodies and diagnostic uses thereof
CN103003307B (zh) * 2010-03-10 2017-08-11 根马布股份公司 抗c‑MEt的单克隆抗体
US20130295091A1 (en) 2011-01-10 2013-11-07 University Of Zurich Combination therapy including tumor associated antigen binding antibodies
WO2012177972A1 (en) 2011-06-23 2012-12-27 Biogen Idec International Neuroscience Gmbh Anti-alpha synuclein binding molecules
CA2861793C (en) * 2011-12-28 2023-08-01 Immunoqure Ag Method of providing monoclonal auto-antibodies with desired specificity
US10131709B2 (en) 2011-12-28 2018-11-20 Immunoqure Ag Nucleic acid molecules encoding monoclonal antibodies specific for IL-22
CN103382223B (zh) * 2012-04-01 2015-06-10 上海益杰生物技术有限公司 针对表皮生长因子受体隐蔽表位和t细胞抗原的多功能抗体多肽
PT2852613T (pt) * 2012-05-22 2019-05-20 Us Health Recetores de célula t anti-ny-eso-1 murinos
WO2015001047A1 (en) 2013-07-03 2015-01-08 Immunoqure Ag Method of providing anti-human cytokine antibodies for pharmaceutical use
GB201413665D0 (en) 2014-07-03 2014-09-17 Transimmune Ag And Yale University Method for obtaining globally activated monocytes
MA41115A (fr) 2014-12-02 2017-10-10 Biogen Int Neuroscience Gmbh Procédé de traitement de la maladie d'alzheimer
SG11202001281WA (en) 2017-08-22 2020-03-30 Biogen Ma Inc Pharmaceutical compositions containing anti-beta amyloid antibodies
WO2019084538A1 (en) 2017-10-27 2019-05-02 Board Of Regents, The University Of Texas System TUMOR SPECIFIC ANTIBODIES, T CELL RECEPTORS AND METHODS OF IDENTIFICATION THEREOF

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
DE3856559T2 (de) 1987-05-21 2004-04-29 Micromet Ag Multifunktionelle Proteine mit vorbestimmter Zielsetzung
US6723832B1 (en) * 1996-10-03 2004-04-20 Ludwig Institute For Cancer Research Isolated peptides corresponding to amino acid sequences of NY-ESO-1, which bind to MHC Class I and MHC Class II molecules, and uses thereof
US6252052B1 (en) 1996-10-03 2001-06-26 Cornell Research Foundation, Inc Antibodies which bind to NY-ESO-1 cancer associated proteins, and hybridomas which produce these antibodies
EP0362371A4 (en) 1988-04-15 1990-10-24 Protein Design Labs, Inc. Il-2 receptor-specific chimeric antibodies
IL162181A (en) 1988-12-28 2006-04-10 Pdl Biopharma Inc A method of producing humanized immunoglubulin, and polynucleotides encoding the same
AU633698B2 (en) 1990-01-12 1993-02-04 Amgen Fremont Inc. Generation of xenogeneic antibodies
GB9020282D0 (en) 1990-09-17 1990-10-31 Gorman Scott D Altered antibodies and their preparation
NZ255101A (en) 1992-07-24 1997-08-22 Cell Genesys Inc A yeast artificial chromosome (yac) vector containing an hprt minigene expressible in murine stem cells and genetically modified rodent therefor
NZ255831A (en) 1992-08-21 1997-04-24 Biogen Inc Fusion proteins comprising biologically active cargo moiety and transport peptides from the hiv tat protein, their preparation and use
EP1978033A3 (en) 1995-04-27 2008-12-24 Amgen Fremont Inc. Human antibodies derived from immunized xenomice
CA2219486A1 (en) 1995-04-28 1996-10-31 Abgenix, Inc. Human antibodies derived from immunized xenomice
US6251603B1 (en) 1996-10-03 2001-06-26 Ludwig Institute For Cancer Research Method for determining status of a cancerous condition by determining antibodies to NY-ESO-1 in a patient sample
US20030236209A1 (en) 1998-03-18 2003-12-25 Corixa Corporation Compositions and methods for the therapy and diagnosis of lung cancer
US7579160B2 (en) * 1998-03-18 2009-08-25 Corixa Corporation Methods for the detection of cervical cancer
US6140050A (en) * 1998-06-26 2000-10-31 Ludwig Institute For Cancer Research Methods for determining breast cancer and melanoma by assaying for a plurality of antigens associated therewith
AU6266899A (en) * 1998-10-05 2000-04-26 Ludwig Institute For Cancer Research Methods for producing human tumor antigen specific antibodies
WO2000030680A1 (en) 1998-11-23 2000-06-02 Idec Pharmaceuticals Corporation Tumor antigen-specific antibody-gp39 chimeric protein constructs
DE19903525A1 (de) 1999-01-29 2000-08-03 Mewa Recycling Maschinen Und A Zerlegungseinrichtung für Altgeräte
EP1571211B1 (en) * 2002-11-22 2010-01-20 Chugai Seiyaku Kabushiki Kaisha Antibodies against lesional tissues
US7993864B2 (en) * 2002-12-03 2011-08-09 Ucb Pharma S.A. Assay for identifying antibody producing cells
EP1608684A2 (en) * 2003-02-07 2005-12-28 Protein Design Labs, Inc. Amphiregulin antibodies and their use to treat cancer and psoriasis
WO2004078776A2 (en) * 2003-03-04 2004-09-16 Ludwig Institute For Cancer Research Ny-eso-1 peptides which bind to class ii molecules and uses thereof
US20080139464A1 (en) * 2003-05-30 2008-06-12 Ludwig Institute Of Cancer Research Isolated Ny-Eso-1 Peptides Which Bind To Hla Class II Molecules And Uses Thereof
GB0409940D0 (en) 2004-05-04 2004-06-09 Glaxosmithkline Biolog Sa Vaccine
ATE505727T1 (de) * 2004-05-26 2011-04-15 Fraunhofer Ges Forschung Isolation allergen-spezifischer immunoglobulin- gene aus humanen b-zellen von atopikern
GB0412973D0 (en) * 2004-06-10 2004-07-14 Celltech R&D Ltd Identification of antibody producing cells
DE102006027224B3 (de) * 2006-06-12 2008-01-03 Repower Systems Ag Windenergieanlage mit einer autarken Energieversorgung für eine Blattverstelleinrichtung
SI2436696T1 (sl) 2007-01-05 2017-10-30 University Of Zurich Anti-beta-amiloidno protitelo in načini njegove uporabe

Also Published As

Publication number Publication date
NZ579520A (en) 2012-06-29
BRPI0808940B1 (pt) 2019-10-08
EP2457928B1 (en) 2017-05-10
US20100330075A1 (en) 2010-12-30
PL2134746T3 (pl) 2015-01-30
KR20100014690A (ko) 2010-02-10
EP3159355A1 (en) 2017-04-26
RU2488593C2 (ru) 2013-07-27
BRPI0808940A8 (pt) 2019-02-05
EP2125888A1 (en) 2009-12-02
AU2008225994B2 (en) 2014-12-11
CN101652388B (zh) 2013-12-25
PL2457928T3 (pl) 2017-10-31
EP2134746A1 (en) 2009-12-23
PT2457928T (pt) 2017-08-17
EP2457928A2 (en) 2012-05-30
AU2008225994B9 (en) 2014-12-18
AU2008225994A1 (en) 2008-09-18
US20110123447A1 (en) 2011-05-26
EP2457928A3 (en) 2012-06-20
IL200615A0 (en) 2010-05-17
WO2008110372A1 (en) 2008-09-18
JP2010520760A (ja) 2010-06-17
ES2637214T3 (es) 2017-10-11
CA2680914A1 (en) 2008-09-18
EP2134746B1 (en) 2014-08-06
RU2009137784A (ru) 2011-04-20
WO2008110373A1 (en) 2008-09-18
CN101652388A (zh) 2010-02-17
HUE035762T2 (en) 2018-05-28
IL200615A (en) 2017-05-29
US8519106B2 (en) 2013-08-27
DK2457928T3 (en) 2017-08-28
JP5797687B2 (ja) 2015-10-21
CA2680914C (en) 2019-06-18
ES2523194T3 (es) 2014-11-21
BRPI0808940B8 (pt) 2021-05-25
KR101570702B1 (ko) 2015-11-23
JP2013223494A (ja) 2013-10-31
BRPI0808940A2 (pt) 2014-08-19
EP2125888B1 (en) 2015-12-02
MX2009009926A (es) 2010-03-15

Similar Documents

Publication Publication Date Title
HRP20181616T1 (hr) Potpuno ljudska anti-vap-1 monoklonska antitijela
IL200615A0 (en) Monoclonal human tumor-specific antibody
IL200610A0 (en) Human monoclonal anti-ip-10 antibodies and uses thereof
IL216381A0 (en) Antagonistic human light-specific human monoclonal antibodies
SG10201604258YA (en) Anti-tnf antibody formulations
EP2021373A4 (en) MONOCLONAL ANTIBODY VCAM-1 SPECIFIC
HK1146728A1 (en) Modified antibody constant region
IL200168A0 (en) Monoclonal anti-cxcl13 antibodies
SG10201601279SA (en) Monoclonal Antibody STRO-4
IL204835A0 (en) Humanized antibody
EP2109625A4 (en) USE OF ANTIBODY CONJUGATES
HK1153502A1 (zh) 抗體
EP2230250A4 (en) ANTI-HIV MONOCLONAL ANTIBODY
HK1158977A1 (zh) 抗膜鐵轉運蛋白 單克隆抗體及其用途
ZA200901165B (en) Antagonistic human light-specific human monoclonal antibodies
ZA200901481B (en) Smallpox monoclonal antibody
GB0706965D0 (en) Humanized antibody
GB0706964D0 (en) Humanized antibody
GB0706963D0 (en) Humanized antibody