ZA200903268B - Spiroketone acetyl-coa carboxylase inhibitors - Google Patents
Spiroketone acetyl-coa carboxylase inhibitorsInfo
- Publication number
- ZA200903268B ZA200903268B ZA200903268A ZA200903268A ZA200903268B ZA 200903268 B ZA200903268 B ZA 200903268B ZA 200903268 A ZA200903268 A ZA 200903268A ZA 200903268 A ZA200903268 A ZA 200903268A ZA 200903268 B ZA200903268 B ZA 200903268B
- Authority
- ZA
- South Africa
- Prior art keywords
- spiroketone
- acetyl
- coa carboxylase
- carboxylase inhibitors
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/39—Heterocyclic compounds having sulfur as a ring hetero atom having oxygen in the same ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US86177906P | 2006-11-29 | 2006-11-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200903268B true ZA200903268B (en) | 2010-07-28 |
Family
ID=39126209
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200903268A ZA200903268B (en) | 2006-11-29 | 2009-05-12 | Spiroketone acetyl-coa carboxylase inhibitors |
Country Status (23)
Country | Link |
---|---|
US (1) | US20090270435A1 (ru) |
EP (1) | EP2097420B1 (ru) |
JP (1) | JP2010511035A (ru) |
KR (1) | KR20090083956A (ru) |
CN (1) | CN101541809A (ru) |
AP (1) | AP2009004880A0 (ru) |
AT (1) | ATE552262T1 (ru) |
AU (1) | AU2007326950B2 (ru) |
BR (1) | BRPI0721053A2 (ru) |
CA (1) | CA2670422C (ru) |
CO (1) | CO6180424A2 (ru) |
CR (1) | CR10831A (ru) |
EA (1) | EA200900613A1 (ru) |
EC (1) | ECSP099371A (ru) |
IL (1) | IL198779A0 (ru) |
MA (1) | MA30932B1 (ru) |
MX (1) | MX2009005604A (ru) |
NO (1) | NO20091889L (ru) |
RS (1) | RS20090249A (ru) |
SV (1) | SV2009003281A (ru) |
TN (1) | TN2009000204A1 (ru) |
WO (1) | WO2008065508A1 (ru) |
ZA (1) | ZA200903268B (ru) |
Families Citing this family (67)
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PE20081559A1 (es) * | 2007-01-12 | 2008-11-20 | Merck & Co Inc | DERIVADOS DE ESPIROCROMANONA SUSTITUIDOS COMO INHIBIDORES DE ACETIL CoA CARBOXILASA |
JP5271917B2 (ja) * | 2007-01-12 | 2013-08-21 | メルク・シャープ・アンド・ドーム・コーポレーション | スピロクロマノン誘導体 |
CN100550853C (zh) * | 2007-01-25 | 2009-10-14 | 华为技术有限公司 | 一种基于输出队列的流控实现方法及装置 |
DE102007028521A1 (de) * | 2007-06-21 | 2008-12-24 | Merck Patent Gmbh | Indazolamidderivate |
WO2009144555A1 (en) * | 2008-05-28 | 2009-12-03 | Pfizer Inc. | Pyrazolospiroketone acetyl-coa carboxylase inhibitors |
ES2545231T3 (es) * | 2008-05-28 | 2015-09-09 | Pfizer Inc. | Inhibidores de pirazoloespirocetona acetil-CoA carboxilasa |
EP2307422B1 (en) * | 2008-07-04 | 2014-03-26 | Msd K.K. | Novel spirochromanone carboxylic acids |
US8110570B2 (en) | 2008-07-14 | 2012-02-07 | Cropsolution, Inc. | Modulators of acetyl-coenzyme A carboxylase and methods of use thereof |
DE102008038222A1 (de) | 2008-08-18 | 2010-02-25 | Merck Patent Gmbh | Indazol-5-carbonsäurehydrazid-derivate |
EP2184276A1 (en) | 2008-11-07 | 2010-05-12 | Universite Paul Cezanne Aix-Marseille Iii | Process to prepare new substituted 1H-Benzo(d) imidazol-2(3h)-Ones, New intermediates and their use as bace 1 inhibitors |
DK2499139T3 (da) | 2009-11-10 | 2014-01-27 | Pfizer | N1-pyrazolospiroketon-acetyl-coa-carboxylasehæmmere |
CA2778316A1 (en) * | 2009-11-10 | 2011-05-19 | Pfizer Inc. | N-2 pyrazolospiroketone acetyl-coa carboxylase inhibitors |
SI2547679T1 (sl) | 2010-03-19 | 2015-12-31 | Pfizer Inc. | Derivati 2,3 dihidro-1H-inden-1-il-2,7-diazaspiro(3.6)nonana in njihova uporaba kot antagonisti ali inverzni agonisti grelinskega receptorja |
EP2595989B1 (en) | 2010-05-06 | 2016-07-13 | Vertex Pharmaceuticals Incorporated | Heterocyclic chromene-spirocyclic piperidine amides as modulators of ion channels |
EP2582709B1 (de) | 2010-06-18 | 2018-01-24 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
HUE031616T2 (hu) | 2010-09-30 | 2017-07-28 | Pfizer | N1-pirazol-spiroketon acetil-koenzim-A karboxiláz inhibítorok |
NZ609527A (en) | 2010-10-29 | 2014-03-28 | Pfizer | N1/n2-lactam acetyl-coa carboxylase inhibitors |
US8916565B2 (en) | 2011-02-02 | 2014-12-23 | Vertex Pharmaceuticals Incorporated | Pyrrolopyrazine-spirocyclic piperidine amides as modulators of ion channels |
EP2675812B1 (en) * | 2011-02-18 | 2017-08-30 | Vertex Pharmaceuticals Incorporated | Chroman - spirocyclic piperidine amides as modulators of ion channels |
AU2012229187B2 (en) | 2011-03-14 | 2016-11-10 | Vertex Pharmaceuticals Incorporated | Morpholine-spirocyclic piperidine amides as modulators of ion channels |
CN103492388A (zh) | 2011-04-22 | 2014-01-01 | 辉瑞大药厂 | 用作乙酰辅酶a羧化酶抑制剂类的吡唑并螺酮衍生物 |
WO2013007603A1 (de) | 2011-07-08 | 2013-01-17 | Bayer Intellectual Property Gmbh | Verfahren zur herstellung von 2-amino-5-cyano-n,3-dimethylbenzamid |
WO2013011402A1 (en) | 2011-07-15 | 2013-01-24 | Pfizer Inc. | Gpr 119 modulators |
WO2013014569A1 (en) | 2011-07-22 | 2013-01-31 | Pfizer Inc. | Quinolinyl glucagon receptor modulators |
CN103857657B (zh) | 2011-08-18 | 2016-04-20 | 日本新药株式会社 | 杂环衍生物及医药 |
EP2751116B1 (en) | 2011-08-31 | 2016-10-12 | Pfizer Inc | Hexahydropyrano [3,4-d][1,3]thiazin-2-amine compounds |
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US8889730B2 (en) | 2012-04-10 | 2014-11-18 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
JP6110937B2 (ja) | 2012-05-04 | 2017-04-05 | ファイザー・インク | APP、BACE1、およびBACE2の阻害剤としての複素環式置換ヘキサヒドロピラノ[3,4−d][1,3]チアジン−2−アミン化合物 |
JP2015529239A (ja) | 2012-09-20 | 2015-10-05 | ファイザー・インク | アルキル置換ヘキサヒドロピラノ[3,4−d][1,3]チアジン−2−アミン化合物 |
EP2931731A1 (en) | 2012-12-11 | 2015-10-21 | Pfizer Inc. | Hexahydropyrano [3,4-d][1,3]thiazin-2-amine compounds as inhibitors of bace1 |
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WO2014125394A1 (en) | 2013-02-13 | 2014-08-21 | Pfizer Inc. | HETEROARYL-SUBSTITUTED HEXAHYDROPYRANO [3,4-d][1,3] THIAZIN-2-AMINE COMPOUNDS |
US9233981B1 (en) | 2013-02-15 | 2016-01-12 | Pfizer Inc. | Substituted phenyl hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds |
JP6348582B2 (ja) | 2013-10-09 | 2018-06-27 | ファイザー・インク | プロスタグランジンep3受容体の拮抗薬 |
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WO2016203335A1 (en) | 2015-06-18 | 2016-12-22 | Pfizer Inc. | Novel pyrido[2,3-b]pyrazinones as bet-family bromodomain inhibitors |
CA2995153A1 (en) | 2015-08-13 | 2017-02-16 | Pfizer Inc. | Bicyclic-fused heteroaryl or aryl compounds |
PT3341367T (pt) | 2015-08-27 | 2021-04-19 | Pfizer | Compostos de arilo ou heteroarilo bicíclicos fusionados como moduladores de irak4 |
WO2017037567A1 (en) | 2015-09-03 | 2017-03-09 | Pfizer Inc. | Regulators of frataxin |
WO2017051276A1 (en) | 2015-09-24 | 2017-03-30 | Pfizer Inc. | N-[2-(2-amino-6,6-disubstituted-4, 4a, 5, 6-tetrahydropyrano [3,4-d][1,3] thiazin-8a (8h)-yl) -1, 3-thiazol-4-yl] amides |
EP3353182A1 (en) | 2015-09-24 | 2018-08-01 | Pfizer Inc | Tetrahydropyrano[3,4-d][1,3]oxazin derivatives and their use as bace inhibitors |
JP2018534251A (ja) | 2015-09-24 | 2018-11-22 | ファイザー・インク | Bace阻害剤として有用なn−[2−(3−アミノ−2,5−ジメチル−1,1−ジオキシド−5,6−ジヒドロ−2h−1,2,4−チアジアジン−5−イル)−1,3−チアゾール−4−イル]アミド |
SI3397631T1 (sl) | 2015-12-29 | 2022-01-31 | Pfizer Inc. | Substituirani 3-azabiciklo(3.1.0)heksani kot zaviralci ketoheksokinaze |
AU2017296338A1 (en) | 2016-07-14 | 2019-01-03 | Pfizer Inc. | Novel pyrimidine carboxamides as inhibitors of vanin-1 enzyme |
AR109179A1 (es) | 2016-08-19 | 2018-11-07 | Pfizer | Inhibidores de diacilglicerol aciltransferasa 2 |
WO2019133445A1 (en) | 2017-12-28 | 2019-07-04 | Inception Ibd, Inc. | Aminothiazoles as inhibitors of vanin-1 |
CN108658938B (zh) * | 2018-06-15 | 2021-03-23 | 上海现代制药股份有限公司 | 一种甲磺酸达比加群酯工艺杂质的合成方法 |
CN108774242B (zh) * | 2018-08-22 | 2020-10-27 | 牡丹江医学院 | 一种防治冠心病的药物及其制备方法 |
US11254660B2 (en) | 2018-08-31 | 2022-02-22 | Pfizer Inc. | Combinations for treatment of NASH/NAFLD and related diseases |
CN109400618B (zh) * | 2018-11-09 | 2021-08-10 | 中国药科大学 | 一种色满衍生物及其制备方法和应用 |
WO2020102575A1 (en) | 2018-11-16 | 2020-05-22 | Inception Ibd, Inc. | Heterocyclic aminothiazoles and uses thereof |
CN109809992A (zh) * | 2019-02-16 | 2019-05-28 | 安徽华胜医药科技有限公司 | 一种2-(2-氟-3-甲氧基苯基)-2-羟基乙酸乙酯的合成方法 |
EP3972596A1 (en) | 2019-05-20 | 2022-03-30 | Pfizer Inc. | Combinations comprising benzodioxol as glp-1r agonists for use in the treatment of nash/nafld and related diseases |
CN110128347A (zh) * | 2019-06-17 | 2019-08-16 | 韶远科技(上海)有限公司 | 一种1-甲基-1h-吲唑-6-甲酸的合成方法 |
GB201910304D0 (en) | 2019-07-18 | 2019-09-04 | Ctxt Pty Ltd | Compounds |
WO2022095971A1 (zh) * | 2020-11-06 | 2022-05-12 | 上海医药集团股份有限公司 | 一种螺杂环类化合物、其制备方法及应用 |
WO2023169456A1 (en) | 2022-03-09 | 2023-09-14 | Gasherbrum Bio , Inc. | Heterocyclic glp-1 agonists |
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IL96507A0 (en) * | 1989-12-08 | 1991-08-16 | Merck & Co Inc | Nitrogen-containing spirocycles and pharmaceutical compositions containing them |
CA2221842A1 (en) * | 1995-06-06 | 1996-12-12 | Merck & Co., Inc. | Alpha 1a adrenergic receptor antagonists |
WO2002020509A2 (de) * | 2000-09-06 | 2002-03-14 | Bayer Aktiengesellschaft | Arzneimittel gegen virale erkrankungen |
JPWO2004092179A1 (ja) * | 2003-04-14 | 2006-07-06 | 日本曹達株式会社 | スピロ誘導体、製造法および抗酸化薬 |
JP2005119987A (ja) * | 2003-10-15 | 2005-05-12 | Ajinomoto Co Inc | アシルスルホンアミド誘導体 |
EP1802623A1 (en) * | 2004-10-12 | 2007-07-04 | Novo Nordisk A/S | 11beta-hydroxysteroid dehydrogenase type 1 active spiro compounds |
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-
2007
- 2007-11-16 EA EA200900613A patent/EA200900613A1/ru unknown
- 2007-11-16 RS RSP-2009/0249A patent/RS20090249A/sr unknown
- 2007-11-16 AP AP2009004880A patent/AP2009004880A0/xx unknown
- 2007-11-16 CN CNA2007800442537A patent/CN101541809A/zh active Pending
- 2007-11-16 WO PCT/IB2007/003639 patent/WO2008065508A1/en active Application Filing
- 2007-11-16 EP EP07825738A patent/EP2097420B1/en active Active
- 2007-11-16 MX MX2009005604A patent/MX2009005604A/es not_active Application Discontinuation
- 2007-11-16 AT AT07825738T patent/ATE552262T1/de active
- 2007-11-16 AU AU2007326950A patent/AU2007326950B2/en not_active Expired - Fee Related
- 2007-11-16 US US12/514,596 patent/US20090270435A1/en not_active Abandoned
- 2007-11-16 KR KR1020097013481A patent/KR20090083956A/ko not_active Application Discontinuation
- 2007-11-16 BR BRPI0721053-1A patent/BRPI0721053A2/pt not_active IP Right Cessation
- 2007-11-16 JP JP2009538803A patent/JP2010511035A/ja active Pending
- 2007-11-16 CA CA2670422A patent/CA2670422C/en not_active Expired - Fee Related
-
2009
- 2009-05-12 ZA ZA200903268A patent/ZA200903268B/xx unknown
- 2009-05-14 NO NO20091889A patent/NO20091889L/no not_active Application Discontinuation
- 2009-05-14 IL IL198779A patent/IL198779A0/en unknown
- 2009-05-22 TN TNP2009000204A patent/TN2009000204A1/fr unknown
- 2009-05-28 CO CO09054954A patent/CO6180424A2/es not_active Application Discontinuation
- 2009-05-28 CR CR10831A patent/CR10831A/es not_active Application Discontinuation
- 2009-05-29 MA MA31936A patent/MA30932B1/fr unknown
- 2009-05-29 SV SV2009003281A patent/SV2009003281A/es not_active Application Discontinuation
- 2009-05-29 EC EC2009009371A patent/ECSP099371A/es unknown
Also Published As
Publication number | Publication date |
---|---|
NO20091889L (no) | 2009-06-17 |
WO2008065508A1 (en) | 2008-06-05 |
CR10831A (es) | 2009-06-18 |
EP2097420A1 (en) | 2009-09-09 |
SV2009003281A (es) | 2010-08-17 |
EA200900613A1 (ru) | 2009-10-30 |
CA2670422A1 (en) | 2008-06-05 |
ECSP099371A (es) | 2009-06-30 |
IL198779A0 (en) | 2010-02-17 |
EP2097420B1 (en) | 2012-04-04 |
JP2010511035A (ja) | 2010-04-08 |
AU2007326950A1 (en) | 2008-06-05 |
KR20090083956A (ko) | 2009-08-04 |
TN2009000204A1 (fr) | 2010-10-18 |
CO6180424A2 (es) | 2010-07-19 |
MX2009005604A (es) | 2009-06-08 |
US20090270435A1 (en) | 2009-10-29 |
ATE552262T1 (de) | 2012-04-15 |
AP2009004880A0 (en) | 2009-06-30 |
MA30932B1 (fr) | 2009-11-02 |
BRPI0721053A2 (pt) | 2014-07-29 |
AU2007326950B2 (en) | 2010-10-14 |
RS20090249A (en) | 2010-06-30 |
CN101541809A (zh) | 2009-09-23 |
CA2670422C (en) | 2011-09-06 |
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