ZA200902451B - Process for the synthesis of derivatives of 3-amino-tetrahydrofuran-3-carboxylic acid and use thereof as medicaments - Google Patents

Process for the synthesis of derivatives of 3-amino-tetrahydrofuran-3-carboxylic acid and use thereof as medicaments

Info

Publication number
ZA200902451B
ZA200902451B ZA200902451A ZA200902451A ZA200902451B ZA 200902451 B ZA200902451 B ZA 200902451B ZA 200902451 A ZA200902451 A ZA 200902451A ZA 200902451 A ZA200902451 A ZA 200902451A ZA 200902451 B ZA200902451 B ZA 200902451B
Authority
ZA
South Africa
Prior art keywords
medicaments
tetrahydrofuran
synthesis
derivatives
amino
Prior art date
Application number
ZA200902451A
Other languages
English (en)
Inventor
Zhengxu Han
Kai Gerlach
Dhileepkumar Krishnamurthy
Burkhard Matthes
Herbert Nar
Roland Pfau
Henning Priepke
Annette Schuler-Metz
Chris Hugh Senanayake
Peter Sieger
Wenjun Tang
Wolfgang Wienen
Yibo Xu
Nathan K Yee
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of ZA200902451B publication Critical patent/ZA200902451B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Furan Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
ZA200902451A 2006-12-31 2009-04-08 Process for the synthesis of derivatives of 3-amino-tetrahydrofuran-3-carboxylic acid and use thereof as medicaments ZA200902451B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US88293706P 2006-12-31 2006-12-31

Publications (1)

Publication Number Publication Date
ZA200902451B true ZA200902451B (en) 2010-05-26

Family

ID=39253961

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200902451A ZA200902451B (en) 2006-12-31 2009-04-08 Process for the synthesis of derivatives of 3-amino-tetrahydrofuran-3-carboxylic acid and use thereof as medicaments

Country Status (23)

Country Link
US (2) US20100317848A1 (fr)
EP (1) EP2114909A2 (fr)
JP (1) JP2010514729A (fr)
KR (1) KR20090097208A (fr)
CN (1) CN101573346B (fr)
AR (1) AR064708A1 (fr)
AU (1) AU2007341335A1 (fr)
BR (1) BRPI0720748A2 (fr)
CA (1) CA2674168A1 (fr)
CL (1) CL2007003875A1 (fr)
EA (1) EA200900797A1 (fr)
EC (1) ECSP099406A (fr)
MA (1) MA31116B1 (fr)
MY (1) MY148769A (fr)
NO (1) NO20091782L (fr)
NZ (1) NZ578715A (fr)
PE (1) PE20081834A1 (fr)
TN (1) TN2009000276A1 (fr)
TW (1) TW200846345A (fr)
UA (1) UA96973C2 (fr)
UY (1) UY30851A1 (fr)
WO (1) WO2008080891A2 (fr)
ZA (1) ZA200902451B (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20070171A1 (es) 2005-06-30 2007-03-08 Boehringer Ingelheim Int GLICINAMIDAS SUSTITUIDAS CON EFECTO ANTITROMBOTICO E INHIBIDOR DEL FACTOR Xa
JP5524852B2 (ja) 2007-11-15 2014-06-18 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 置換アミド、それらの製造及び医薬品としての使用
WO2012120128A1 (fr) * 2011-03-09 2012-09-13 Csl Behring Gmbh Inhibiteurs du facteur xii destinés à être administrés avec des procédures médicales comprenant le contact avec des surfaces artificielles
EP2497489A1 (fr) * 2011-03-09 2012-09-12 CSL Behring GmbH Inhibiteur du facteur XII pour le traitement de la pénombre ischémique cérébrale et l'ischémie d'autres organes
US9096579B2 (en) 2012-04-20 2015-08-04 Boehringer Ingelheim International Gmbh Amino-indolyl-substituted imidazolyl-pyrimidines and their use as medicaments
WO2014060575A2 (fr) * 2012-10-19 2014-04-24 Medichem S.A. Procédé de synthèse énantiosélective d'un composé tétrahydrobenzazépine
RU2520134C1 (ru) * 2013-02-27 2014-06-20 Общество с ограниченной ответственностью "Авионко" (ООО "Авионко") Замещенные (r)-3-(4-метилкарбамоил-3-фторфениламино)-тетрагидро-фуран-3-енкарбоновые кислоты и их эфиры, способ их получения и применения
US10286047B2 (en) 2013-03-08 2019-05-14 Csl Behring Gmbh Treatment and prevention of remote ischemia-reperfusion injury
CN105431415A (zh) * 2013-05-20 2016-03-23 斯洛文尼亚莱柯制药股份有限公司 通过烯烃的弗瑞德-克来福特烷基化进行的8-氯-3-苯并[d]氮杂*的新合成方法
CN104530029B (zh) * 2014-12-09 2017-04-12 广东东阳光药业有限公司 作为Xa因子抑制剂的杂环化合物及其使用方法和用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0510019A (pt) * 2004-05-13 2007-09-25 Boehringer Ingelheim Int amidas de ácido tiofenocarboxìlico substituìdas, sua preparação e seu uso como medicamento
WO2005111013A1 (fr) * 2004-05-13 2005-11-24 Boehringer Ingelheim International Gmbh Amides d'acide thiophene-2-carboxylique substitues, leur production et leur utilisation comme medicament
JP2007537181A (ja) * 2004-05-13 2007-12-20 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 置換されたチオフェン−カルボン酸アミド、医薬品の形態におけるこれらの製造及び使用
DE102004047840A1 (de) * 2004-09-29 2006-03-30 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue substituierte Thiophencarbonsäureamide, deren Herstellung und deren Verwendung als Arzneimittel
PE20070171A1 (es) * 2005-06-30 2007-03-08 Boehringer Ingelheim Int GLICINAMIDAS SUSTITUIDAS CON EFECTO ANTITROMBOTICO E INHIBIDOR DEL FACTOR Xa

Also Published As

Publication number Publication date
AR064708A1 (es) 2009-04-22
TW200846345A (en) 2008-12-01
CL2007003875A1 (es) 2008-04-18
PE20081834A1 (es) 2009-01-16
EP2114909A2 (fr) 2009-11-11
BRPI0720748A2 (pt) 2015-05-19
NZ578715A (en) 2012-06-29
AU2007341335A1 (en) 2008-07-10
US20130005962A1 (en) 2013-01-03
NO20091782L (no) 2009-06-10
MY148769A (en) 2013-05-31
WO2008080891A2 (fr) 2008-07-10
TN2009000276A1 (fr) 2010-10-18
ECSP099406A (es) 2009-07-31
EA200900797A1 (ru) 2009-12-30
US20100317848A1 (en) 2010-12-16
MA31116B1 (fr) 2010-01-04
CN101573346B (zh) 2013-01-09
CN101573346A (zh) 2009-11-04
WO2008080891A3 (fr) 2008-10-02
CA2674168A1 (fr) 2008-07-10
UA96973C2 (ru) 2011-12-26
JP2010514729A (ja) 2010-05-06
UY30851A1 (es) 2008-07-31
KR20090097208A (ko) 2009-09-15

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