MA31116B1 - Procede de synthese de derives de l'acide 3-amino-tetrahydro-furan-3-carboxylique et utilisation de ceux-ci en tant que medicaments - Google Patents

Procede de synthese de derives de l'acide 3-amino-tetrahydro-furan-3-carboxylique et utilisation de ceux-ci en tant que medicaments

Info

Publication number
MA31116B1
MA31116B1 MA32126A MA32126A MA31116B1 MA 31116 B1 MA31116 B1 MA 31116B1 MA 32126 A MA32126 A MA 32126A MA 32126 A MA32126 A MA 32126A MA 31116 B1 MA31116 B1 MA 31116B1
Authority
MA
Morocco
Prior art keywords
amino
carboxylic acid
general formula
synthesis
medicaments
Prior art date
Application number
MA32126A
Other languages
Arabic (ar)
English (en)
Inventor
Zhengxu Han
Kai Gerlach
Dhileepkumar Krishnamurthy
Burkhard Matthes
Herbert Nar
Roland Pfau
Henning Priepke
Annette Schuler-Metz
Chris H Senanayake
Peter Sieger
Wenjun Tang
Wolfgang Wienen
Yibo Xu
Nathan K Yee
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of MA31116B1 publication Critical patent/MA31116B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Furan Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

La présente invention concerne un procédé de fabrication d'amides d'acide 3-amino-tétrahydrofuran-3-carboxylique substitués de formule générale (i) et de leurs précurseurs avec une grande pureté optique, de précurseurs de la synthèse d'amides d'acide 3-amino-tétrahydrofuran-3-carboxylique substitués de formule générale (i) avec une grande pureté optique, ainsi que de tautomères, énantiomères, diastéréoisomères, mélanges et sels d'amides d'acide 3-amino-tétrahydrofuran-3-carboxylique substitués de formule générale (i) avec une grande pureté optique et, en particulier, de leurs sels acceptables sur le plan physiologique avec des acides ou des bases inorganiques ou organiques, présentant des propriétés intéressantes. Ainsi, la présente invention concerne la préparation stéréosélective de composés de formule générale (i) ci-dessus.
MA32126A 2006-12-31 2009-07-29 Procede de synthese de derives de l'acide 3-amino-tetrahydro-furan-3-carboxylique et utilisation de ceux-ci en tant que medicaments MA31116B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US88293706P 2006-12-31 2006-12-31
PCT/EP2007/064406 WO2008080891A2 (fr) 2006-12-31 2007-12-21 Procédé de synthèse de dérivés de l'acide 3-amino-tétrahydrofuran-3-carboxylique et utilisation de ceux-ci en tant que médicaments

Publications (1)

Publication Number Publication Date
MA31116B1 true MA31116B1 (fr) 2010-01-04

Family

ID=39253961

Family Applications (1)

Application Number Title Priority Date Filing Date
MA32126A MA31116B1 (fr) 2006-12-31 2009-07-29 Procede de synthese de derives de l'acide 3-amino-tetrahydro-furan-3-carboxylique et utilisation de ceux-ci en tant que medicaments

Country Status (23)

Country Link
US (2) US20100317848A1 (fr)
EP (1) EP2114909A2 (fr)
JP (1) JP2010514729A (fr)
KR (1) KR20090097208A (fr)
CN (1) CN101573346B (fr)
AR (1) AR064708A1 (fr)
AU (1) AU2007341335A1 (fr)
BR (1) BRPI0720748A2 (fr)
CA (1) CA2674168A1 (fr)
CL (1) CL2007003875A1 (fr)
EA (1) EA200900797A1 (fr)
EC (1) ECSP099406A (fr)
MA (1) MA31116B1 (fr)
MY (1) MY148769A (fr)
NO (1) NO20091782L (fr)
NZ (1) NZ578715A (fr)
PE (1) PE20081834A1 (fr)
TN (1) TN2009000276A1 (fr)
TW (1) TW200846345A (fr)
UA (1) UA96973C2 (fr)
UY (1) UY30851A1 (fr)
WO (1) WO2008080891A2 (fr)
ZA (1) ZA200902451B (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20070171A1 (es) 2005-06-30 2007-03-08 Boehringer Ingelheim Int GLICINAMIDAS SUSTITUIDAS CON EFECTO ANTITROMBOTICO E INHIBIDOR DEL FACTOR Xa
US8741890B2 (en) 2007-11-15 2014-06-03 Boehringer Ingelheim International Gmbh Substituted amides, manufacturing and use thereof as medicaments
US9352016B2 (en) 2011-03-09 2016-05-31 Csl Behring Gmbh Factor XII inhibitors for the administration with medical procedures comprising contact with artificial surfaces
EP2497489A1 (fr) 2011-03-09 2012-09-12 CSL Behring GmbH Inhibiteur du facteur XII pour le traitement de la pénombre ischémique cérébrale et l'ischémie d'autres organes
US9096579B2 (en) 2012-04-20 2015-08-04 Boehringer Ingelheim International Gmbh Amino-indolyl-substituted imidazolyl-pyrimidines and their use as medicaments
WO2014060575A2 (fr) * 2012-10-19 2014-04-24 Medichem S.A. Procédé de synthèse énantiosélective d'un composé tétrahydrobenzazépine
RU2520134C1 (ru) * 2013-02-27 2014-06-20 Общество с ограниченной ответственностью "Авионко" (ООО "Авионко") Замещенные (r)-3-(4-метилкарбамоил-3-фторфениламино)-тетрагидро-фуран-3-енкарбоновые кислоты и их эфиры, способ их получения и применения
AU2014224599B2 (en) 2013-03-08 2018-11-08 Csl Behring Gmbh Treatment and prevention of remote ischemia-reperfusion injury
CN105431415A (zh) * 2013-05-20 2016-03-23 斯洛文尼亚莱柯制药股份有限公司 通过烯烃的弗瑞德-克来福特烷基化进行的8-氯-3-苯并[d]氮杂*的新合成方法
CN104530029B (zh) * 2014-12-09 2017-04-12 广东东阳光药业有限公司 作为Xa因子抑制剂的杂环化合物及其使用方法和用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007537181A (ja) * 2004-05-13 2007-12-20 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 置換されたチオフェン−カルボン酸アミド、医薬品の形態におけるこれらの製造及び使用
CA2562714A1 (fr) * 2004-05-13 2005-11-24 Boehringer Ingelheim International Gmbh Amides d'acide thiophene-2-carboxylique substitues, leur production et leur utilisation comme medicament
WO2005111029A1 (fr) * 2004-05-13 2005-11-24 Boehringer Ingelheim International Gmbh Nouveaux thiophene-carboxamides substitues, leur production et leur utilisation en tant que medicaments
DE102004047840A1 (de) * 2004-09-29 2006-03-30 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue substituierte Thiophencarbonsäureamide, deren Herstellung und deren Verwendung als Arzneimittel
PE20070171A1 (es) * 2005-06-30 2007-03-08 Boehringer Ingelheim Int GLICINAMIDAS SUSTITUIDAS CON EFECTO ANTITROMBOTICO E INHIBIDOR DEL FACTOR Xa

Also Published As

Publication number Publication date
NZ578715A (en) 2012-06-29
ZA200902451B (en) 2010-05-26
CN101573346B (zh) 2013-01-09
WO2008080891A3 (fr) 2008-10-02
TW200846345A (en) 2008-12-01
US20100317848A1 (en) 2010-12-16
CL2007003875A1 (es) 2008-04-18
US20130005962A1 (en) 2013-01-03
TN2009000276A1 (fr) 2010-10-18
UA96973C2 (ru) 2011-12-26
PE20081834A1 (es) 2009-01-16
CA2674168A1 (fr) 2008-07-10
ECSP099406A (es) 2009-07-31
AR064708A1 (es) 2009-04-22
NO20091782L (no) 2009-06-10
EA200900797A1 (ru) 2009-12-30
UY30851A1 (es) 2008-07-31
JP2010514729A (ja) 2010-05-06
CN101573346A (zh) 2009-11-04
MY148769A (en) 2013-05-31
WO2008080891A2 (fr) 2008-07-10
BRPI0720748A2 (pt) 2015-05-19
EP2114909A2 (fr) 2009-11-11
AU2007341335A1 (en) 2008-07-10
KR20090097208A (ko) 2009-09-15

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