ZA200808195B - Thioxanthine derivatives and their use as inhibitors of MPO - Google Patents

Thioxanthine derivatives and their use as inhibitors of MPO

Info

Publication number
ZA200808195B
ZA200808195B ZA200808195A ZA200808195A ZA200808195B ZA 200808195 B ZA200808195 B ZA 200808195B ZA 200808195 A ZA200808195 A ZA 200808195A ZA 200808195 A ZA200808195 A ZA 200808195A ZA 200808195 B ZA200808195 B ZA 200808195B
Authority
ZA
South Africa
Prior art keywords
mpo
inhibitors
thioxanthine derivatives
thioxanthine
derivatives
Prior art date
Application number
ZA200808195A
Other languages
English (en)
Inventor
Tiden Anna-Karin
Viklund Jenny
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38609780&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA200808195(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of ZA200808195B publication Critical patent/ZA200808195B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/20—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/22—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one sulfur atom
ZA200808195A 2006-04-13 2008-09-25 Thioxanthine derivatives and their use as inhibitors of MPO ZA200808195B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US79166706P 2006-04-13 2006-04-13

Publications (1)

Publication Number Publication Date
ZA200808195B true ZA200808195B (en) 2009-08-26

Family

ID=38609780

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200808195A ZA200808195B (en) 2006-04-13 2008-09-25 Thioxanthine derivatives and their use as inhibitors of MPO

Country Status (18)

Country Link
US (1) US8026244B2 (xx)
EP (1) EP2010535B1 (xx)
JP (1) JP2009533427A (xx)
KR (2) KR20080109087A (xx)
CN (1) CN101466712A (xx)
AR (1) AR060429A1 (xx)
AU (1) AU2007239147A1 (xx)
BR (1) BRPI0711529A2 (xx)
CA (1) CA2649150A1 (xx)
CL (1) CL2007001042A1 (xx)
EC (1) ECSP088821A (xx)
ES (1) ES2389266T3 (xx)
MX (1) MX2008013033A (xx)
NO (1) NO20084764L (xx)
TW (1) TW200806667A (xx)
UY (1) UY30267A1 (xx)
WO (1) WO2007120098A1 (xx)
ZA (1) ZA200808195B (xx)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR039385A1 (es) * 2002-04-19 2005-02-16 Astrazeneca Ab Derivados de tioxantina como inhibidores de la mieloperoxidasa
MY140748A (en) 2004-12-06 2010-01-15 Astrazeneca Ab Novel pyrrolo [3,2-d] pyrimidin-4-one derivatives and their use in therapy
US20090286813A1 (en) * 2006-04-13 2009-11-19 Astrazeneca Ab Thioxanthine Derivatives and Their Use as Inhibitors of MPO
TW200804383A (en) * 2006-06-05 2008-01-16 Astrazeneca Ab New compounds
AR066936A1 (es) * 2007-06-13 2009-09-23 Astrazeneca Ab 3 - (2r - tetrahidrofuril - metil) - 2 - tioxantina. composiciones farmaceuticas.
US20090053176A1 (en) * 2007-08-23 2009-02-26 Astrazeneca Ab New Combination 937
US20090054468A1 (en) * 2007-08-23 2009-02-26 Astrazeneca Ab New Use 938
WO2010068171A1 (en) * 2008-12-12 2010-06-17 Astrazeneca Ab A process for the preparation of 3- [ (2r) tetrahydrofuran-2- ylmethyl] -2-thioxo-l, 2, 3, 7-tetrahydro-6h-purin-6-one
GB0913345D0 (en) 2009-07-31 2009-09-16 Astrazeneca Ab New combination 802
WO2011061527A1 (en) 2009-11-17 2011-05-26 Astrazeneca Ab Combinations comprising a glucocorticoid receptor modulator for the treatment of respiratory diseases
GB201021979D0 (en) 2010-12-23 2011-02-02 Astrazeneca Ab New compound
GB201021992D0 (en) 2010-12-23 2011-02-02 Astrazeneca Ab Compound
MX351299B (es) 2011-11-11 2017-10-10 Pfizer 2-tiopirimidinonas.
JP2015512905A (ja) * 2012-03-29 2015-04-30 ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ 有害動物を駆除するためのｎ−置換複素二環式化合物および誘導体ｉｉ
US20170247343A1 (en) 2014-09-11 2017-08-31 Bristol-Myers Squibb Company Thioether triazolopyridine and triazolopyrimidine inhibitors of myeloperoxidase
US9616063B2 (en) 2014-12-01 2017-04-11 Astrazeneca Ab 1-[2-(aminomethyl)benzyl]-2-thioxo-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-ones as inhibitors of myeloperoxidase
MA42035A (fr) 2015-05-05 2018-03-14 Pfizer 2-thiopyrimidinones
US10316035B2 (en) 2015-09-03 2019-06-11 Bristol-Myers Squibb Company Triazolopyridine inhibitors of myeloperoxidase
WO2017160632A1 (en) * 2016-03-14 2017-09-21 Bristol-Myers Squibb Company Triazolopyridine inhibitors of myeloperoxidase
CN115403584B (zh) * 2021-05-26 2024-04-02 长春金赛药业有限责任公司 2-硫代-2,3-二氢嘧啶-4-酮衍生物、药物组合物及其制备方法和应用
WO2024038131A1 (en) 2022-08-18 2024-02-22 Astrazeneca Ab Inhibitors of myeloperoxidase

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9312853D0 (en) * 1993-06-22 1993-08-04 Euro Celtique Sa Chemical compounds
WO1995002604A1 (en) * 1993-07-13 1995-01-26 The United States Of America, Represented By The Secretary, Department Of Health And Human Services A3 adenosine receptor agonists
US5708009A (en) * 1993-12-21 1998-01-13 Eli Lilly And Company Methods of inhibiting myeloperoxidase activity
US6780865B1 (en) * 1994-02-18 2004-08-24 Cell Therapeutics, Inc. Compounds having selective hydrolytic potentials
EP0814809B1 (en) * 1994-12-13 2003-08-13 Euroceltique S.A. Aryl thioxanthines
ES2264210T3 (es) * 1997-09-05 2006-12-16 Kyowa Hakko Kogyo Co., Ltd. Derivados de xantina para el tratamiento de la isquemia cerebral.
KR20020065341A (ko) * 1999-04-02 2002-08-13 유로-셀티크 소시에떼 아노뉨 포스포디에스트라스(phosphodiesterase, PDE) Ⅳ 억제작용을 가진 푸린 유도체
AR039385A1 (es) * 2002-04-19 2005-02-16 Astrazeneca Ab Derivados de tioxantina como inhibidores de la mieloperoxidasa
SE0302756D0 (sv) * 2003-10-17 2003-10-17 Astrazeneca Ab Novel Compounds
MY140748A (en) * 2004-12-06 2010-01-15 Astrazeneca Ab Novel pyrrolo [3,2-d] pyrimidin-4-one derivatives and their use in therapy
US20090286813A1 (en) * 2006-04-13 2009-11-19 Astrazeneca Ab Thioxanthine Derivatives and Their Use as Inhibitors of MPO
TW200804383A (en) * 2006-06-05 2008-01-16 Astrazeneca Ab New compounds
US20090054468A1 (en) * 2007-08-23 2009-02-26 Astrazeneca Ab New Use 938

Also Published As

Publication number Publication date
BRPI0711529A2 (pt) 2011-11-01
UY30267A1 (es) 2007-11-30
NO20084764L (no) 2009-01-06
EP2010535A1 (en) 2009-01-07
ES2389266T3 (es) 2012-10-24
WO2007120098A1 (en) 2007-10-25
US20090149475A1 (en) 2009-06-11
CN101466712A (zh) 2009-06-24
TW200806667A (en) 2008-02-01
AR060429A1 (es) 2008-06-18
CL2007001042A1 (es) 2008-02-08
US8026244B2 (en) 2011-09-27
KR20090109087A (ko) 2009-10-19
AU2007239147A1 (en) 2007-10-25
MX2008013033A (es) 2008-10-17
JP2009533427A (ja) 2009-09-17
EP2010535A4 (en) 2011-07-20
CA2649150A1 (en) 2007-10-25
EP2010535B1 (en) 2012-07-11
ECSP088821A (es) 2008-11-27
KR20080109087A (ko) 2008-12-16

Similar Documents

Publication Publication Date Title
EP2010534A4 (en) THIOXANTHINE DERIVATIVES AND THEIR USE AS DFO INHIBITORS
ZA200808195B (en) Thioxanthine derivatives and their use as inhibitors of MPO
HK1254895A1 (zh) 苄基苯衍生物及使用方法
IL198397A0 (en) Anilinopiperazine derivatives and methods of use thereof
HRP20192282T8 (hr) Inhibitori tfpi i postupci upotrebe
PT2050749T (pt) Derivado de pirimidina como inibidador de pi3k e sua utilização
IL201836A0 (en) Pyrrolopyridine derivatives and their use as bace inhibitors
IL196956A0 (en) Aza-benzofuranyl compounds and methods of use
NO345061B1 (no) Anvendelse av DPP-IV inhibitorer
IL200639A0 (en) Benzimidazole derivatives and methods of use thereof
ZA200901593B (en) Pyrimidines derivatives and their use as kinase inhibitors
IL198927A0 (en) Imidazopyridine inhibitors of iap
EP2188295A4 (en) PYRIDINE DERIVATIVES AND METHODS OF USE
IL193693A0 (en) Purine compounds and methods of use thereof
IL192557A0 (en) Substituted imidazole derivatives and their use as ptpase inhibitors
ZA201002853B (en) Some 2-pyrazinone derivatives and their use as inhibitors of neutrophile elastase
IL197060A0 (en) Aza-benzothiophenyl compounds and methods of use
EP2137168A4 (en) NEW IDO INHIBITORS AND METHODS OF USE
HK1137756A1 (en) Substituted dihydropyrazolones and use thereof as hif-prolyl-4 -hydroxylase inhibitors hif--4-
IL196594A0 (en) Derivatives of 4-trimethylammonium-3-aminobutyrate and 4-trimethylphosphonium-3-aminobutyrate as cpt-inhibitors
EP2099299A4 (en) OXAZOLIDINONE DERIVATIVES AND METHOD FOR THEIR USE
EP2126056A4 (en) INHIBITORS OF THE PARAMYXOVIRUS FAMILY AND METHODS OF USE THEREOF
ZA200900907B (en) Pyrimidine derivative as P13K inhibitor and use thereof
TWI372762B (en) Amino derivatives of b-homoandrostanes and b-heteroandrostanes
ZA200900896B (en) Aza-benzofuranyl compounds and methods of use