ZA200807674B - Prodrugs of benzoquinolizine-2-carboxylic acid - Google Patents

Prodrugs of benzoquinolizine-2-carboxylic acid

Info

Publication number
ZA200807674B
ZA200807674B ZA200807674A ZA200807674A ZA200807674B ZA 200807674 B ZA200807674 B ZA 200807674B ZA 200807674 A ZA200807674 A ZA 200807674A ZA 200807674 A ZA200807674 A ZA 200807674A ZA 200807674 B ZA200807674 B ZA 200807674B
Authority
ZA
South Africa
Prior art keywords
benzoquinolizine
prodrugs
carboxylic acid
carboxylic
acid
Prior art date
Application number
ZA200807674A
Other languages
English (en)
Inventor
Patel Mahesh Vithalbhai
Desai Vijaya Narayan
Deshpande Prasad Keshav
Yeole Ravindra Dattatrya
Kale Rajesh Prabhakar
Original Assignee
Wockhardt Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wockhardt Ltd filed Critical Wockhardt Ltd
Publication of ZA200807674B publication Critical patent/ZA200807674B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ZA200807674A 2006-03-07 2007-03-01 Prodrugs of benzoquinolizine-2-carboxylic acid ZA200807674B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN321MU2006 2006-03-07

Publications (1)

Publication Number Publication Date
ZA200807674B true ZA200807674B (en) 2009-11-25

Family

ID=37691768

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200807674A ZA200807674B (en) 2006-03-07 2007-03-01 Prodrugs of benzoquinolizine-2-carboxylic acid

Country Status (15)

Country Link
US (1) US7868173B2 (ja)
EP (1) EP1993547B1 (ja)
JP (1) JP5384119B2 (ja)
KR (2) KR20130128483A (ja)
CN (1) CN101500564B (ja)
AU (1) AU2007222115B2 (ja)
BR (1) BRPI0708606A2 (ja)
CA (1) CA2644661C (ja)
ES (1) ES2393802T3 (ja)
MX (1) MX2008011376A (ja)
NZ (1) NZ570865A (ja)
PL (1) PL1993547T3 (ja)
RU (1) RU2434867C2 (ja)
WO (1) WO2007102061A2 (ja)
ZA (1) ZA200807674B (ja)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2536408A1 (en) * 2010-02-16 2012-12-26 Wockhardt Research Centre Efflux pump inhibitors
KR20140054307A (ko) * 2011-09-28 2014-05-08 욱크하르트 리미티드 순수한 S-(-)-9-플루오로-6,7-디히드로-8-(4-히드록시피페리딘-1-일)-5-메틸-1-옥소-1H,-5H-벤조[i,j]퀴놀리진-2-카르복실산 L-아르기닌 염 테트라하이드레이트 및 이의 제조 방법
CN107580493A (zh) * 2015-05-08 2018-01-12 沃克哈特有限公司 包含抗细菌剂的稳定的药物组合物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3029293B2 (ja) * 1995-06-15 2000-04-04 ファイザー・インコーポレーテッド ジペプチドを含む、アザビシクロナフチリジンカルボン酸の誘導体を調製するための方法
MA24500A1 (fr) * 1997-03-21 1998-10-01 Lg Life Sciences Ltd Derive du sel d'acide carboxylique de naphthyridine .
US6750224B1 (en) 1999-05-07 2004-06-15 Wockhardt Limited Antibacterial optically pure benzoquinolizine carboxylic acids, processes, compositions and methods of treatment
EP2030620A1 (en) * 1999-05-07 2009-03-04 Wockhardt Limited (s)-benzoquinolizine carboxylic acids and their use as antibacterial agents
CA2417799A1 (en) * 2000-08-01 2002-02-07 Wockhardt Limited Inhibitors of cellular efflux pumps of microbes
KR100517638B1 (ko) * 2002-04-08 2005-09-28 주식회사 엘지생명과학 게미플록사신 산염의 새로운 제조방법
CA2546039A1 (en) * 2003-11-20 2005-07-21 Wockhardt Limited Novel polymorphs of racemic, dextrorotatory, and levorotatory enantiomers of 1-cyclopropyl-6-fluoro-8-methoxy-7-(4-amino-3,3-dimethylpiperidin-1-yl)-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid hydrochloride and mesylate salts

Also Published As

Publication number Publication date
WO2007102061A2 (en) 2007-09-13
RU2008139613A (ru) 2010-04-20
MX2008011376A (es) 2009-02-06
RU2434867C2 (ru) 2011-11-27
BRPI0708606A2 (pt) 2011-06-14
US7868173B2 (en) 2011-01-11
CA2644661A1 (en) 2007-09-13
JP5384119B2 (ja) 2014-01-08
EP1993547B1 (en) 2012-08-22
NZ570865A (en) 2010-11-26
EP1993547A4 (en) 2009-11-11
WO2007102061A3 (en) 2009-04-23
PL1993547T3 (pl) 2013-08-30
JP2009529029A (ja) 2009-08-13
CN101500564A (zh) 2009-08-05
CA2644661C (en) 2013-12-31
ES2393802T3 (es) 2012-12-28
KR101364900B1 (ko) 2014-02-19
CN101500564B (zh) 2012-07-25
KR20130128483A (ko) 2013-11-26
US20070219227A1 (en) 2007-09-20
AU2007222115B2 (en) 2011-05-12
AU2007222115A1 (en) 2007-09-13
KR20090009795A (ko) 2009-01-23
EP1993547A2 (en) 2008-11-26

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