ZA200705835B - Compounds useful in the treatment of HIV - Google Patents
Compounds useful in the treatment of HIVInfo
- Publication number
- ZA200705835B ZA200705835B ZA200705835A ZA200705835A ZA200705835B ZA 200705835 B ZA200705835 B ZA 200705835B ZA 200705835 A ZA200705835 A ZA 200705835A ZA 200705835 A ZA200705835 A ZA 200705835A ZA 200705835 B ZA200705835 B ZA 200705835B
- Authority
- ZA
- South Africa
- Prior art keywords
- hiv
- treatment
- compounds useful
- hydroxymethylcytidine
- dideoxy
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 1
- WZGBNAXNHRMYLG-ZXFLCMHBSA-N 4-amino-1-[(2r,4r,5s)-4,5-bis(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one Chemical compound O=C1N=C(N)C=CN1[C@@H]1O[C@H](CO)[C@@H](CO)C1 WZGBNAXNHRMYLG-ZXFLCMHBSA-N 0.000 abstract 1
- 108020004414 DNA Proteins 0.000 abstract 1
- 102000053602 DNA Human genes 0.000 abstract 1
- 208000031886 HIV Infections Diseases 0.000 abstract 1
- 208000037357 HIV infectious disease Diseases 0.000 abstract 1
- 102100034343 Integrase Human genes 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- 108010092799 RNA-directed DNA polymerase Proteins 0.000 abstract 1
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 abstract 1
- 235000011180 diphosphates Nutrition 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 230000035772 mutation Effects 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71453604P | 2004-12-30 | 2004-12-30 | |
| EP05100063A EP1679076A1 (en) | 2005-01-06 | 2005-01-06 | Compounds useful in the treatment of HIV |
| PCT/EP2005/057196 WO2006070004A1 (en) | 2004-12-30 | 2005-12-28 | Compounds useful in the treatment of hiv |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200705835B true ZA200705835B (en) | 2008-05-28 |
Family
ID=39705001
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200705835A ZA200705835B (en) | 2004-12-30 | 2007-07-16 | Compounds useful in the treatment of HIV |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7829548B2 (zh) |
| EP (1) | EP1835916B1 (zh) |
| CN (1) | CN101132795B (zh) |
| AT (1) | ATE427110T1 (zh) |
| AU (1) | AU2005321239B2 (zh) |
| BR (1) | BRPI0519306A2 (zh) |
| CA (1) | CA2594229A1 (zh) |
| DE (1) | DE602005013697D1 (zh) |
| EA (1) | EA011039B1 (zh) |
| ES (1) | ES2325088T3 (zh) |
| HK (1) | HK1107518A1 (zh) |
| WO (1) | WO2006070004A1 (zh) |
| ZA (1) | ZA200705835B (zh) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0513835D0 (en) * | 2005-07-07 | 2005-08-10 | Medivir Ab | HIV inhibitors |
| CN101260135B (zh) * | 2008-04-16 | 2011-05-25 | 厦门大学 | 一种高级脂肪酸齐多夫定酯的合成方法 |
| US9187783B2 (en) | 2010-10-04 | 2015-11-17 | Genapsys, Inc. | Systems and methods for automated reusable parallel biological reactions |
| US9399217B2 (en) | 2010-10-04 | 2016-07-26 | Genapsys, Inc. | Chamber free nanoreactor system |
| US9184099B2 (en) | 2010-10-04 | 2015-11-10 | The Board Of Trustees Of The Leland Stanford Junior University | Biosensor devices, systems and methods therefor |
| CN103717753B (zh) * | 2011-05-27 | 2016-12-07 | 吉纳普赛斯股份有限公司 | 用于遗传和生物分析的系统和方法 |
| US9926596B2 (en) | 2011-05-27 | 2018-03-27 | Genapsys, Inc. | Systems and methods for genetic and biological analysis |
| US8585973B2 (en) | 2011-05-27 | 2013-11-19 | The Board Of Trustees Of The Leland Stanford Junior University | Nano-sensor array |
| WO2013082619A1 (en) | 2011-12-01 | 2013-06-06 | Genapsys, Inc. | Systems and methods for high efficiency electronic sequencing and detection |
| US9809852B2 (en) | 2013-03-15 | 2017-11-07 | Genapsys, Inc. | Systems and methods for biological analysis |
| US10125393B2 (en) | 2013-12-11 | 2018-11-13 | Genapsys, Inc. | Systems and methods for biological analysis and computation |
| EP3132060B1 (en) | 2014-04-18 | 2019-03-13 | Genapsys Inc. | Methods and systems for nucleic acid amplification |
| CN109790575A (zh) | 2016-07-20 | 2019-05-21 | 吉纳普赛斯股份有限公司 | 用于核酸测序的系统和方法 |
| CA3076378A1 (en) | 2017-09-21 | 2019-03-28 | Genapsys, Inc. | Systems and methods for nucleic acid sequencing |
| CN110890132A (zh) * | 2019-11-19 | 2020-03-17 | 湖南大学 | 基于自适应高斯混合模型的癌症突变簇识别方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8810907D0 (en) | 1988-05-09 | 1988-06-15 | British Telecomm | Fluoride glass optical coupler & method of manufacture |
| FI95384C (fi) | 1989-04-06 | 1996-01-25 | Squibb Bristol Myers Co | Menetelmä 3'-deoksi-3'-substituoitujen metyylinukleosidien valmistamiseksi ja menetelmässä käytettäviä välituotteita |
| DE4026265A1 (de) | 1990-08-20 | 1992-02-27 | Boehringer Mannheim Gmbh | Neue phospholipid-derivate von nucleosiden, deren herstellung sowie deren verwendung als antivirale arzneimittel |
| US5563257A (en) | 1990-08-20 | 1996-10-08 | Boehringer Mannheim Gmbh | Phospholipid derivatives of nucleosides |
| SE9003151D0 (sv) | 1990-10-02 | 1990-10-02 | Medivir Ab | Nucleoside derivatives |
| DE4418690A1 (de) | 1994-05-28 | 1996-01-11 | Boehringer Mannheim Gmbh | Neue Lipidester von Nucleosid-Monophosphaten und deren Verwendung als immunsuppressive Arzneimittel |
| WO1995032983A1 (en) | 1994-05-31 | 1995-12-07 | Medivir Ab | Post exposure prevention of hiv |
| US5612319A (en) | 1994-05-31 | 1997-03-18 | Medivir Ab | Postexposure prevention of HIV infection or seroconversion |
| DE19602757A1 (de) | 1996-01-26 | 1997-07-31 | Boehringer Mannheim Gmbh | Feste Instant-Release-Darreichungsformen und Verfahren zu ihrer Herstellung |
| US5869493A (en) | 1996-02-16 | 1999-02-09 | Medivir Ab | Acyclic nucleoside derivatives |
-
2005
- 2005-12-28 DE DE602005013697T patent/DE602005013697D1/de active Active
- 2005-12-28 AU AU2005321239A patent/AU2005321239B2/en not_active Ceased
- 2005-12-28 BR BRPI0519306-0A patent/BRPI0519306A2/pt not_active IP Right Cessation
- 2005-12-28 CA CA002594229A patent/CA2594229A1/en not_active Abandoned
- 2005-12-28 WO PCT/EP2005/057196 patent/WO2006070004A1/en active Application Filing
- 2005-12-28 US US11/813,085 patent/US7829548B2/en not_active Expired - Fee Related
- 2005-12-28 CN CN200580048871XA patent/CN101132795B/zh not_active Expired - Fee Related
- 2005-12-28 EP EP05850502A patent/EP1835916B1/en active Active
- 2005-12-28 ES ES05850502T patent/ES2325088T3/es active Active
- 2005-12-28 EA EA200701406A patent/EA011039B1/ru not_active IP Right Cessation
- 2005-12-28 AT AT05850502T patent/ATE427110T1/de not_active IP Right Cessation
-
2007
- 2007-07-16 ZA ZA200705835A patent/ZA200705835B/xx unknown
- 2007-09-28 HK HK07110585.3A patent/HK1107518A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| HK1107518A1 (en) | 2008-04-11 |
| US20080176817A1 (en) | 2008-07-24 |
| CN101132795B (zh) | 2011-09-21 |
| CN101132795A (zh) | 2008-02-27 |
| EA200701406A1 (ru) | 2008-02-28 |
| EP1835916B1 (en) | 2009-04-01 |
| US7829548B2 (en) | 2010-11-09 |
| EP1835916A1 (en) | 2007-09-26 |
| AU2005321239B2 (en) | 2009-02-12 |
| ATE427110T1 (de) | 2009-04-15 |
| CA2594229A1 (en) | 2006-07-06 |
| ES2325088T3 (es) | 2009-08-25 |
| EA011039B1 (ru) | 2008-12-30 |
| DE602005013697D1 (de) | 2009-05-14 |
| AU2005321239A1 (en) | 2006-07-06 |
| BRPI0519306A2 (pt) | 2009-01-06 |
| WO2006070004A1 (en) | 2006-07-06 |
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