ZA200703989B - Use of atazanavir for improving the pharmacokinetics of drugs metabolized by UGT1A1 - Google Patents

Use of atazanavir for improving the pharmacokinetics of drugs metabolized by UGT1A1

Info

Publication number
ZA200703989B
ZA200703989B ZA200703989A ZA200703989A ZA200703989B ZA 200703989 B ZA200703989 B ZA 200703989B ZA 200703989 A ZA200703989 A ZA 200703989A ZA 200703989 A ZA200703989 A ZA 200703989A ZA 200703989 B ZA200703989 B ZA 200703989B
Authority
ZA
South Africa
Prior art keywords
ugt1a1
atazanavir
pharmacokinetics
improving
drugs metabolized
Prior art date
Application number
ZA200703989A
Other languages
English (en)
Inventor
Kassahun Kelem
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of ZA200703989B publication Critical patent/ZA200703989B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
ZA200703989A 2004-12-03 2007-05-17 Use of atazanavir for improving the pharmacokinetics of drugs metabolized by UGT1A1 ZA200703989B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US63294504P 2004-12-03 2004-12-03

Publications (1)

Publication Number Publication Date
ZA200703989B true ZA200703989B (en) 2008-09-25

Family

ID=36565812

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200703989A ZA200703989B (en) 2004-12-03 2007-05-17 Use of atazanavir for improving the pharmacokinetics of drugs metabolized by UGT1A1

Country Status (15)

Country Link
US (1) US20070259894A1 (bg)
EP (1) EP1824957A4 (bg)
JP (1) JP2008521934A (bg)
KR (1) KR20070085702A (bg)
CN (1) CN101068916A (bg)
AU (1) AU2005311672B2 (bg)
BR (1) BRPI0518741A2 (bg)
CA (1) CA2588466A1 (bg)
IL (1) IL183383A0 (bg)
MX (1) MX2007006637A (bg)
NO (1) NO20073403L (bg)
NZ (1) NZ555215A (bg)
RU (1) RU2403066C2 (bg)
WO (1) WO2006060731A2 (bg)
ZA (1) ZA200703989B (bg)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7176196B2 (en) 2004-05-28 2007-02-13 Bristol-Myers Squibb Company Bicyclic heterocycles as HIV integrase inhibitors
US7491819B1 (en) 2004-05-28 2009-02-17 Bristol-Myers Squibb Company N-[4-Fluorophenyl)methyl]-4,6,7,9-tetrahydro-3-hydroxy-9,9-dimethyl-4-oxo-pyrimido[2,1-c][1,4]oxazine-2-carboxamide as an HIV integrase inhibitor
US7192948B2 (en) 2004-05-28 2007-03-20 Bristol-Myers Squibb Company Bicyclic heterocycles as HIV integrase inhibitors
US8852632B2 (en) 2004-12-03 2014-10-07 Merck Sharp & Dohme Corp. Pharmaceutical formulation containing a release rate controlling composition
UA87884C2 (uk) 2004-12-03 2009-08-25 Мерк Энд Ко., Инк. Безводна кристалічна калієва сіль інгібітора віл-інтегрази
EP3165220B1 (en) * 2004-12-03 2019-04-03 Merck Sharp & Dohme Corp. Pharmaceutical composition containing an anti-nucleating agent
ES2356334T3 (es) 2007-06-12 2011-04-07 Concert Pharmaceuticals, Inc. Derivados de azapéptidos como inhibidores de la proteasa vih.
US20100273203A1 (en) * 2009-04-23 2010-10-28 Board Of Trustees Of The University Of Arkansas Methods and compositions for detecting metabolites
US8410064B2 (en) * 2009-08-24 2013-04-02 The Board Of Trustees Of The University Of Arkansas Classical cannabinoid metabolites and methods of use thereof
WO2011026112A1 (en) * 2009-08-31 2011-03-03 The Board Of Trustees Of The University Of Arkansas Compositions comprising specific ugt inhibitors and methods of use thereof
JP6122639B2 (ja) 2009-10-26 2017-04-26 メルク・シャープ・エンド・ドーム・コーポレイション インテグラーゼ阻害剤を含有する固形医薬組成物
US8883218B2 (en) * 2010-03-26 2014-11-11 The Board Of Trustees Of The University Of Arkansas Anti-cancer nanoparticle compositions and methods of use
US9095598B2 (en) 2010-12-28 2015-08-04 The Board Of Trustees Of The University Of Arkansas Stilbenoid derivatives and their uses

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5849911A (en) * 1996-04-22 1998-12-15 Novartis Finance Corporation Antivirally active heterocyclic azahexane derivatives
EA200300449A1 (ru) * 2000-10-12 2003-10-30 Мерк Энд Ко., Инк. Аза- и полиаза-нафталинилкарбоксамиды, полезные в качестве ингибиторов вич-интегразы
PT1441734E (pt) * 2001-10-26 2007-05-31 Isti Di Ric Di Bio Moleco P An Di-hidroxipirimidinocarboxamidas inibidoras da integrase do vih
RS51542B (sr) * 2001-10-26 2011-06-30 Istituto Di Ricerche Di Biologia Molecolare P.Angeletti Spa. N-supstituisani hidroksipirimidinon karboksamidni inhibitori hiv integraze
WO2003055494A1 (en) * 2001-12-21 2003-07-10 Avmax, Inc. Use of ugt inhibitors to increase bioavailability
PL377354A1 (pl) * 2002-12-27 2006-01-23 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa Tetrahydro-4H-pirydo[1,2-a]pirymidyny i związki pokrewne użyteczne jako inhibitory integrazy HIV
US20040192624A1 (en) * 2003-03-24 2004-09-30 Kempf Dale J. Method for treating a disease, disorder or adverse effect caused by an elevated serum concentration of an UGT1A1 substrate
EP3165220B1 (en) * 2004-12-03 2019-04-03 Merck Sharp & Dohme Corp. Pharmaceutical composition containing an anti-nucleating agent
UA87884C2 (uk) * 2004-12-03 2009-08-25 Мерк Энд Ко., Инк. Безводна кристалічна калієва сіль інгібітора віл-інтегрази
US8852632B2 (en) * 2004-12-03 2014-10-07 Merck Sharp & Dohme Corp. Pharmaceutical formulation containing a release rate controlling composition

Also Published As

Publication number Publication date
AU2005311672B2 (en) 2010-07-22
NO20073403L (no) 2007-08-31
KR20070085702A (ko) 2007-08-27
WO2006060731A3 (en) 2006-09-28
NZ555215A (en) 2010-08-27
EP1824957A4 (en) 2011-02-09
US20070259894A1 (en) 2007-11-08
MX2007006637A (es) 2007-06-19
IL183383A0 (en) 2007-09-20
JP2008521934A (ja) 2008-06-26
AU2005311672A1 (en) 2006-06-08
BRPI0518741A2 (pt) 2008-12-02
CN101068916A (zh) 2007-11-07
WO2006060731A2 (en) 2006-06-08
RU2007125130A (ru) 2009-01-10
RU2403066C2 (ru) 2010-11-10
EP1824957A2 (en) 2007-08-29
CA2588466A1 (en) 2006-06-08

Similar Documents

Publication Publication Date Title
IL183383A0 (en) Use of atazanavir for improving the pharmacokinetics of drugs metabolized by ugt1a1
HRP20160866T1 (hr) Postupci primjene hipoglikemijskih sredstava
TWI366457B (en) Use of a beta2-adrenoceptor agonist for the preparation of a dermatological medicament
AP2702A (en) Methods for improving the pharmacokinetics of HIV integrase inhibitors
AP2037A (en) Use of substituted quinoline derivatives for the treatment of drug resistant mycobacterial diseases
HK1103393A1 (en) Cyclohexane derivative, prodrug thereof and salt thereof, and therapeutic agent containing the same for diabetes
EG24362A (en) Process for the preparation of dehydrogenated hydrocarbon compounds
ZA200708811B (en) Use of a sulfonamide compound for improving the pharma-cokinetics of a drug
SI1710241T1 (sl) Intermediatne spojine za pripravo trans-5-kloro-2-metil-2,3,3a, 12b-tetrahidro-1H-dibenz(2,3:6,7)oksepino(4,5-C)pirola
IL181304A (en) Use of dihydroprididone for the preparation of a drug for the treatment of spinal cord dysplasia
IL177120A0 (en) Formulations for poorly soluble drugs
EP1901733A4 (en) USE OF HUPERZINE FOR DISEASES
IL182834A0 (en) Sulfonamido-macrocycles and the salts thereof, a pharmaceutical composition comprisng these compounds, the method of preparing and the use thereof
IL190323A0 (en) Kit for the parenteral administration of drugs
HRP20121052T8 (en) A medicament for the two-step perioperative therapy of solid tumours by radioimmunotherapy
ZA200700755B (en) Novel cyclohexane derivative, prodrug thereof and salt thereof, and therapeutic agent containing the same for diabetes
AU2002335304A1 (en) The use of berberine as insulin sensitizer
GB0402285D0 (en) Product for administering medication
IL177353A0 (en) Process for the preparation of aq4n
ZA200806222B (en) Methods for improving the pharmacokinetics of HIV integrase inhibitors
PL1591434T3 (pl) Nowe 1-metoksy-2-fenylo-etyleny przydatne do otrzymywania 5-karboksyaldehydu-2-3-dihydrobenzoksepin
PT1600446E (pt) Novos derivados de 3,3-dimetil-5-ciano-benzoxepina úteis para a preparação de derivados de 5-formil-benzoxepina
HU0400812D0 (en) New pharmaceutical agents