ZA200700134B - Antitumor effect fortifier, antitumor agent and method of therapy for cancer - Google Patents
Antitumor effect fortifier, antitumor agent and method of therapy for cancer Download PDFInfo
- Publication number
- ZA200700134B ZA200700134B ZA200700134A ZA200700134A ZA200700134B ZA 200700134 B ZA200700134 B ZA 200700134B ZA 200700134 A ZA200700134 A ZA 200700134A ZA 200700134 A ZA200700134 A ZA 200700134A ZA 200700134 B ZA200700134 B ZA 200700134B
- Authority
- ZA
- South Africa
- Prior art keywords
- antitumor
- tegafur
- gimeracil
- oteracil potassium
- platinum
- Prior art date
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- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
- 229910000397 disodium phosphate Inorganic materials 0.000 description 1
- 235000019800 disodium phosphate Nutrition 0.000 description 1
- 239000008298 dragée Substances 0.000 description 1
- 229940120655 eloxatin Drugs 0.000 description 1
- 239000002662 enteric coated tablet Substances 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 235000019325 ethyl cellulose Nutrition 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 239000007941 film coated tablet Substances 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 231100000414 gastrointestinal toxicity Toxicity 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000007903 gelatin capsule Substances 0.000 description 1
- 235000001727 glucose Nutrition 0.000 description 1
- 125000005456 glyceride group Chemical group 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 239000008172 hydrogenated vegetable oil Substances 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 description 1
- 229960000367 inositol Drugs 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 239000000644 isotonic solution Substances 0.000 description 1
- 229960001375 lactose Drugs 0.000 description 1
- 235000019388 lanolin Nutrition 0.000 description 1
- 229940039717 lanolin Drugs 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 239000003589 local anesthetic agent Substances 0.000 description 1
- 229960003511 macrogol Drugs 0.000 description 1
- 229960002160 maltose Drugs 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 229960001855 mannitol Drugs 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 229920001289 polyvinyl ether Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229910000160 potassium phosphate Inorganic materials 0.000 description 1
- 235000011009 potassium phosphates Nutrition 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 150000003230 pyrimidines Chemical class 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
- 239000004208 shellac Substances 0.000 description 1
- 235000013874 shellac Nutrition 0.000 description 1
- 229940113147 shellac Drugs 0.000 description 1
- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 235000020374 simple syrup Nutrition 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
- 235000010262 sodium metabisulphite Nutrition 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 235000011008 sodium phosphates Nutrition 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000011255 standard chemotherapy Methods 0.000 description 1
- 229960004274 stearic acid Drugs 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000007940 sugar coated tablet Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 229910000406 trisodium phosphate Inorganic materials 0.000 description 1
- 235000019801 trisodium phosphate Nutrition 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- 239000003871 white petrolatum Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/132—Amines having two or more amino groups, e.g. spermidine, putrescine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004171520 | 2004-06-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200700134B true ZA200700134B (en) | 2008-05-28 |
Family
ID=35502806
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200700134A ZA200700134B (en) | 2004-06-09 | 2005-06-02 | Antitumor effect fortifier, antitumor agent and method of therapy for cancer |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US20080306073A1 (zh) |
| EP (1) | EP1757283B1 (zh) |
| JP (1) | JP5578753B2 (zh) |
| CN (2) | CN103054871A (zh) |
| AU (1) | AU2005251588B2 (zh) |
| BR (1) | BRPI0511988A (zh) |
| CA (1) | CA2569739C (zh) |
| CY (1) | CY1113509T1 (zh) |
| DK (1) | DK1757283T3 (zh) |
| EA (1) | EA011573B1 (zh) |
| ES (1) | ES2393398T3 (zh) |
| HR (1) | HRP20121062T1 (zh) |
| IL (1) | IL179885A (zh) |
| ME (1) | ME01460B (zh) |
| MX (1) | MXPA06014477A (zh) |
| MY (1) | MY140563A (zh) |
| NO (1) | NO20070136L (zh) |
| NZ (1) | NZ551637A (zh) |
| PL (1) | PL1757283T3 (zh) |
| PT (1) | PT1757283E (zh) |
| RS (1) | RS52668B (zh) |
| SI (1) | SI1757283T1 (zh) |
| TW (1) | TWI324929B (zh) |
| WO (1) | WO2005120480A1 (zh) |
| ZA (1) | ZA200700134B (zh) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009084216A1 (ja) * | 2007-12-27 | 2009-07-09 | Taiho Pharmaceutical Co., Ltd. | 経口粉粒状抗腫瘍剤 |
| TWI468188B (zh) * | 2008-01-30 | 2015-01-11 | Univ Tokushima | Anti-cancer effect enhancers consisting of oxaliplatin liposomal preparations and anticancer agents comprising the formulation |
| WO2009139085A1 (ja) * | 2008-05-12 | 2009-11-19 | 静岡県 | 抗腫瘍剤、キット及び癌治療方法 |
| JP5553522B2 (ja) * | 2009-03-31 | 2014-07-16 | 大鵬薬品工業株式会社 | 経口投与用医薬組成物 |
| CN102309492A (zh) * | 2010-07-02 | 2012-01-11 | 天津金耀集团有限公司 | 一种替加氟、吉美斯特和奥替拉西钾复方注射液 |
| RU2014141615A (ru) | 2012-03-16 | 2016-05-10 | Тайхо Фармасьютикал Ко., Лтд. | Новое противоопухолевое средство, включающее комбинацию трех агентов |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69519300T2 (de) * | 1994-08-08 | 2001-05-31 | Debiopharm Sa | Stabiles arzneimittel enthaltend oxaliplatin |
| AU2001240001A1 (en) * | 2000-03-08 | 2001-09-17 | Bristol-Myers Squibb Company | Oral dosage form for administration of the combination of tegafur, uracil, folinic acid, and oxaliplatin and method of using the same |
| US6793912B2 (en) * | 2001-08-20 | 2004-09-21 | Transave Inc. | Treatment of cancers by inhalation of stable platinum-containing formulations |
| US6476068B1 (en) * | 2001-12-06 | 2002-11-05 | Pharmacia Italia, S.P.A. | Platinum derivative pharmaceutical formulations |
-
2005
- 2005-06-02 JP JP2006514477A patent/JP5578753B2/ja not_active Expired - Fee Related
- 2005-06-02 EP EP05745983A patent/EP1757283B1/en active Active
- 2005-06-02 SI SI200531637T patent/SI1757283T1/sl unknown
- 2005-06-02 ES ES05745983T patent/ES2393398T3/es active Active
- 2005-06-02 PT PT57459836T patent/PT1757283E/pt unknown
- 2005-06-02 CA CA2569739A patent/CA2569739C/en not_active Expired - Fee Related
- 2005-06-02 CN CN2012104510733A patent/CN103054871A/zh active Pending
- 2005-06-02 NZ NZ551637A patent/NZ551637A/en unknown
- 2005-06-02 WO PCT/JP2005/010182 patent/WO2005120480A1/ja active Application Filing
- 2005-06-02 ZA ZA200700134A patent/ZA200700134B/en unknown
- 2005-06-02 BR BRPI0511988-0A patent/BRPI0511988A/pt not_active Application Discontinuation
- 2005-06-02 PL PL05745983T patent/PL1757283T3/pl unknown
- 2005-06-02 RS RS20120582A patent/RS52668B/en unknown
- 2005-06-02 ME MEP-2013-2A patent/ME01460B/me unknown
- 2005-06-02 CN CNA2005800189099A patent/CN1964707A/zh active Pending
- 2005-06-02 EA EA200602282A patent/EA011573B1/ru not_active IP Right Cessation
- 2005-06-02 AU AU2005251588A patent/AU2005251588B2/en not_active Ceased
- 2005-06-02 DK DK05745983.6T patent/DK1757283T3/da active
- 2005-06-02 MX MXPA06014477A patent/MXPA06014477A/es active IP Right Grant
- 2005-06-02 US US11/629,185 patent/US20080306073A1/en not_active Abandoned
- 2005-06-08 TW TW094118875A patent/TWI324929B/zh active
- 2005-06-09 MY MYPI20052620A patent/MY140563A/en unknown
-
2006
- 2006-12-06 IL IL179885A patent/IL179885A/en active IP Right Grant
-
2007
- 2007-01-08 NO NO20070136A patent/NO20070136L/no not_active Application Discontinuation
-
2012
- 2012-12-21 HR HRP20121062TT patent/HRP20121062T1/hr unknown
-
2013
- 2013-01-04 CY CY20131100005T patent/CY1113509T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TW200603809A (en) | 2006-02-01 |
| PT1757283E (pt) | 2012-12-07 |
| NZ551637A (en) | 2010-05-28 |
| DK1757283T3 (da) | 2012-11-12 |
| IL179885A (en) | 2011-08-31 |
| PL1757283T3 (pl) | 2013-03-29 |
| JPWO2005120480A1 (ja) | 2008-04-03 |
| NO20070136L (no) | 2007-02-09 |
| ES2393398T3 (es) | 2012-12-21 |
| CA2569739A1 (en) | 2005-12-22 |
| MY140563A (en) | 2009-12-31 |
| JP5578753B2 (ja) | 2014-08-27 |
| US20080306073A1 (en) | 2008-12-11 |
| EA200602282A1 (ru) | 2007-04-27 |
| RS52668B (en) | 2013-06-28 |
| SI1757283T1 (sl) | 2013-01-31 |
| IL179885A0 (en) | 2007-05-15 |
| CA2569739C (en) | 2011-11-29 |
| CN1964707A (zh) | 2007-05-16 |
| EP1757283A1 (en) | 2007-02-28 |
| AU2005251588A1 (en) | 2005-12-22 |
| WO2005120480A1 (ja) | 2005-12-22 |
| TWI324929B (en) | 2010-05-21 |
| AU2005251588B2 (en) | 2009-01-08 |
| CY1113509T1 (el) | 2016-06-22 |
| ME01460B (me) | 2014-04-20 |
| BRPI0511988A (pt) | 2008-01-22 |
| EP1757283B1 (en) | 2012-10-17 |
| CN103054871A (zh) | 2013-04-24 |
| EP1757283A4 (en) | 2009-09-02 |
| EA011573B1 (ru) | 2009-04-28 |
| MXPA06014477A (es) | 2007-03-21 |
| HRP20121062T1 (hr) | 2013-01-31 |
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